Anand A Ramamurthi

US Patent:

8529951, Sep 10, 2013

Filed:

Feb 20, 2008

Appl. No.:

12/034237

Inventors:

Anand Ramamurthi - Charleston SC, US
Chandrasekhar Kothapalli - Tarrytown NY, US
Binata Joddar - Dublin OH, US

International Classification:

A61K 38/18

US Classification:

424488, 424461, 424493, 514 76, 514 54, 514499

Abstract:

Disclosed are elastogenic cues that can be utilized to encourage growth and development of elastin-containing cellular constructs. The elastogenic cues include hyaluronan fragments and oligomers, optionally in conjunction with growth factors and/or a source of copper ions. The elastogenic cues can up-regulate elastin matrix synthesis and by vascular smooth muscle cells. In addition to encouraging synthesis of elastin in a cellular matrix and organization into elastic fibers, the elastogenic cues can also stabilize the formed ECM matrix through suppression of elastin-laminin receptor (ELR). In addition, the elastogenic cues can inhibit cell hyper-proliferation (e. g. , hyperplasia) common in inflammatory vascular disease.