Alessio O Giubellino

US Patent:

20070042966, Feb 22, 2007

Filed:

Sep 22, 2006

Appl. No.:

11/525672

Inventors:

Donald Bottaro - Kensington MD, US
Alessio Giubellino - Bethesda MD, US
Safiye Atabey - Alsancak, TR
Jesus Soriano - Washington DC, US
Diane Breckenridge - Bethesda MD, US
Terrence Burke - Bethesda MD, US

Assignee:

Gov't of the USA, represented by the Secretary, Dep't of Health and Human Services - Rockville MD
Office of Technology Transfer - Rockville MD

International Classification:

A61K 38/06
A61K 38/05

US Classification:

514018000

Abstract:

Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. Also disclosed are methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer, for example, melanoma or prostate cancer, comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking blocks HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures.

US Patent:

20110190295, Aug 4, 2011

Filed:

Mar 31, 2009

Appl. No.:

12/935643

Inventors:

Donald P. Bottaro - Kensington MD, US
Megan Peach - Ashburn VA, US
Marc Nicklaus - Catonsville MD, US
Terrence Burke, JR. - Bethesda MD, US
Gagani Athauda - Southwest Ranches FL, US
Sarah Choyke - Rockville MD, US
Alessio Giubellino - Washington DC, US
Nelly Tan - Los Angeles CA, US

Assignee:

The Govt of the U.S.A., as rep.by the Sec.Dept of Hlth. and Human Svcs., Natl Institutes of Health - Rockville MD

International Classification:

A61K 31/5377
C07D 213/85
A61K 31/44
C07D 413/12
C07D 239/02
A61K 31/505
A61P 35/00

US Classification:

5142355, 546288, 514344, 544131, 544311, 514269

Abstract:

Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided.