Yan Dun Cao

US Patent:

60254769, Feb 15, 2000

Filed:

Oct 6, 1998

Appl. No.:

9/167647

Inventors:

Gerd Grieninger - New York NY
Yiping Fu - New York NY
Yan Cao - Valhalla NY
Mohamad Zaher Ahadi - Paterson NJ
Bohdan J. Kudryk - Hillsdale NJ

Assignee:

New York Blood Center, Inc. - New York NY

International Classification:

C07K 1600

US Classification:

5303881

Abstract:

The invention provides monospecific antibodies which are specifically reactive with the. alpha. sub. E subunit of fibrinogen or a fragment thereof, but not with other portions of the fibrinogen molecule. The invention also provides anti-. alpha. sub. E probes, including monospecific anti-. alpha. sub. E antibodies which have been detectably labeled. In addition, the invention provides methods of using the monospecific antibodies for detection of the. alpha. sub. E subunit and fragments thereof, as well as reagents and kits for performing the methods. Diagnostic methods for determining information associated with atherogenesis and/or thrombogenesis, as well as for determining information associated with pregnancy status or outcome. The invention further provides continuous cell lines which produce monospecific anti-. alpha. sub. E antibodies.

US Patent:

58177680, Oct 6, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/479755

Inventors:

Gerd Grieninger - New York NY
Yiping Fu - New York NY
Yan Cao - Valhalla NY
Mohamad Zaher Ahadi - Paterson NJ
Bohdan J. Kudryk - Hillsdale NJ

Assignee:

The New York Blood Center, Inc. - New York NY

International Classification:

C07K 1600
C07K 1700
C12P 2108

US Classification:

5303881

Abstract:

The invention provides nonspecific antibodies which are specifically reactive with the. alpha. sub. E subunit of fibrinogen or a fragment thereof, but not with other portions of the fibrinogen molecule. The invention also provides anti-. alpha. sub. E probes, including nonspecific anti-. alpha. sub. E antibodies which have been detectably labeled. In addition, the invention provides methods of using the nonspecific antibodies for detection of the. alpha. sub. E subunit and fragments thereof, as well as reagents and kits for performing the methods. Diagnostic methods for determining information associated with atherogenesis and/or thrombogenesis, as well as for determining information associated with pregnancy status or outcome. The invention further provides continuous cell lines which produce monospecific anti-. alpha. sub. E antibodies.

US Patent:

60251484, Feb 15, 2000

Filed:

Jul 1, 1997

Appl. No.:

8/886269

Inventors:

Gerd Grieninger - New York NY
Yiping Fu - New York NY
Yan Cao - Valhalla NY
Mohamad Zaher Ahadi - Paterson NJ
Bohdan J. Kudryk - Hillsdale NJ

Assignee:

New York Blood Center, Inc. - New York NY

International Classification:

C07K 1600

US Classification:

435 792

Abstract:

The invention provides monospecific antibodies which are specifically reactive with the. alpha. hd E subunit of fibrinogen or a fragment thereof, but not with other portions of the fibrinogen molecule. The invention also provides anti-. alpha. sub. E probes, including monospecific anti-. alpha. sub. E antibodies which have been detectably labeled. In addition, the invention provides methods of using the monospecific antibodies for detection of the. alpha. sub. E subunit and fragments thereof, as well as reagents and kits for performing the methods. Diagnostic methods for determining information associated with atherogenesis and/or thrombogenesis, as well as for determining information associated with pregnancy status or outcome. The invention further provides continuous cell lines which produce monospecific anti-. alpha. sub. E antibodies.