Vincent G Miller

Author:

Vincent C. Miller

ISBN #:

0878340807

Author:

Vincent Miller

ISBN #:

0595161766

Author:

Vincent Miller

ISBN #:

0595167985

Author:

Vincent Miller

ISBN #:

0595183778

Author:

Vincent Miller

ISBN #:

0595194036

Author:

Vincent Miller

ISBN #:

0442253923

Author:

Vincent Miller

ISBN #:

0826415318

Author:

Vincent Miller

ISBN #:

0826417493

US Patent:

8067175, Nov 29, 2011

Filed:

Feb 13, 2006

Appl. No.:

11/815985

Inventors:

Harold Varmus - New York NY, US
Katerina Politi - New York NY, US
William Pao - New York NY, US
Vincent Miller - New York NY, US

Assignee:

Memorial Sloan-Kettering Cancer Center - New York NY

International Classification:

C12Q 1/68

US Classification:

435 612

Abstract:

Polymerase chain reaction primers and methods directed to detecting the EGFR mutant C→T at the position corresponding to base 2369 of EGFR cDNA. The invention provides a PCR primer that hybridizes under suitable PCR conditions to a polynucleotide sequence 5′ in each respective strand to a mutation of an EGFR gene that encodes a substitution of threonine by methionine at position 790 of the EGFR polypeptide. The invention also provides a PCR primer hybridizes to a sequence that includes a mutant T at the position corresponding to base 2369 of EGFR cDNA but not to a second EGFR polynucleotide containing a wild type C. The invention provides several methods and kits for detecting a mutant epidermal growth factor receptor (EGFR) gene in a sample comprising probing the sample with a means for selectively detecting a nucleotide sequence comprising a mutant T at the position corresponding to base 2369 of EGFR cDNA, and identifying that the base at said position is T. These methods and kits are also useful to predict resistance to the therapeutic effects of gefitinib or erlotinib in a subject suffering from or suspected of having a cancer.

US Patent:

8501413, Aug 6, 2013

Filed:

Oct 17, 2011

Appl. No.:

13/275161

Inventors:

Harold Varmus - New York NY, US
Katerina Politi - New York NY, US
William Pao - New York NY, US
Vincent Miller - New York NY, US

Assignee:

Memorial-Sloan Kettering Cancer Center - New York NY

International Classification:

C12Q 1/68

US Classification:

435 612

Abstract:

Development of acquired resistance to the therapeutic effects of an epidermal growth factor (EGFR) tyrosine kinase inhibitor in a patient that is suffering from a cancer is predicted by:.

US Patent:

46258132, Dec 2, 1986

Filed:

Jun 17, 1985

Appl. No.:

6/745450

Inventors:

Arvind J. Trivedi - Englishtown NJ
Vincent G. Miller - Westfield NJ

International Classification:

E21B 1002

US Classification:

175 20

Abstract:

Coring of a subaqueous structure having a significant water pressure head on one side is carried out through a full port valve assembly mounted on the inner or dry side of the structure. With the valve open, the barrel of a coring device is inserted, and a core is cut and removed. The valve is closed to prevent inflow of soil and water. The hole from which the core has been removed can be sealed by injecting a grouting compound through the mounted ball valve assembly, or can be injected by means of a mechanical packer. The valve assembly permits coring to be interrupted, for example, to permit rail service operations through a subaqueous railroad tunnel.

US Patent:

53684141, Nov 29, 1994

Filed:

Jul 19, 1991

Appl. No.:

7/732787

Inventors:

Vincent G. Miller - Westfield NJ

International Classification:

E02D 2902

US Classification:

405262

Abstract:

The invention relates to a method and system for rehabilitation of an existing retaining wall or bulkhead.

US Patent:

20150366866, Dec 24, 2015

Filed:

Jan 17, 2014

Appl. No.:

14/761518

Inventors:

Vincent A. Miller - West Orange NJ, US
- Cambridge MA, US
Jie He - Newton MA, US
Doron Lipson - Chestnut Hill MA, US
Jeffrey S. Ross - Lebanon Springs NY, US
Philip James Stephens - Lexington MA, US

International Classification:

A61K 31/5025
C07K 16/40
C12Q 1/68
G01N 33/573
C12N 9/12
A61K 31/4412
C12N 15/113

Abstract:

Methods and compositions for treating cholangiocarcinoma.