Robert W Orr

US Patent:

20110124867, May 26, 2011

Filed:

Dec 16, 2008

Appl. No.:

12/809101

Inventors:

Frank Xing Chen - Plainsboro NJ, US
Timothy D. Cutarelli - Clinton NJ, US
Xiayong Fu - Edison NJ, US
Xian Liang - Monmouth Junction NJ, US
Timothy L. McAllister - , US
Robert K. Orr - Cranford NJ, US
Jianguo Yin - Plainsboro NJ, US
Kelvin H. Yong - Lyndhurst NJ, US
Man Zhu - Clark NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 413/14
C07D 401/14
C07D 403/04
C07D 241/04
C07D 211/44

US Classification:

544357, 544389, 546220

Abstract:

The present invention relates to novel processes for the preparation of the compound of the Formula A45:or a physiologically acceptable salt, solvate or prodrug thereof, which has utility, for example, as a pharmaceutically active compound with CXCR3 antagonist activity, and to novel intermediates useful in the synthesis thereof.

US Patent:

20140031549, Jan 30, 2014

Filed:

Oct 1, 2013

Appl. No.:

14/043210

Inventors:

Gerald Werne - Ketsch, DE
Xiaoyong Fu - Edison NJ, US
Robert K. Orr - Cranford NJ, US
Frank Xing Chen - Plainsboro NJ, US
Jian Cui - Edison NJ, US
Victoria M. Sprague - Bridgewater NJ, US
Fucheng Zhang - Edison NJ, US
Ji Xie - Edison NJ, US
Liansheng Zeng - Union NJ, US
Louis Peter Castellanos - Union City NJ, US
Yuyin Chen - Garwood NJ, US
Marc Poirier - Stewartsville NJ, US
Ingrid Mergelsberg - Mahwah NJ, US

Assignee:

OPKO Health, Inc. - Miami FL

International Classification:

C07D 471/10
C07D 207/267
C07C 217/48
C07D 498/04

US Classification:

546 16, 548217, 548530, 564346, 548550

Abstract:

This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

US Patent:

46909532, Sep 1, 1987

Filed:

Mar 11, 1986

Appl. No.:

6/838575

Inventors:

Robert B. Orr - Wilmington DE
Leon Chicosky - Newark DE

Assignee:

Seton Company - Newark NJ

International Classification:

C08G 1814

US Classification:

521 65

Abstract:

A method of mechanically frothing and casting an aqueous ionic polyurethane dispersion to yield a mechanically frothed polyurethane foam. The method comprises admixing an aqueous ionic polyurethane dispersion with a stearate stabilizer and an optional aziridine crosslinking agent, and frothing the low viscosity admixture. The polyurethane dispersion contains particles having an average size of less than one micron, and contains between 35 and 70 percent by weight dispersed polyurethane solids. Preferably, each polyurethane particle in the aqueous dispersion is crosslinked. Before frothing, the low viscosity admixture contains between 33 and 87 percent by weight of the polyurethane dispersion, up to 33 percent by weight of an azirdine composition and between 13 and 50 percent by weight of a 33 percent aqueous dispersion of a stearate salt and has, as a result, a viscosity in the range of 100 to 200 centipoise. After frothing, the frothed admixture is knife-coated and cured into a flexible foam sheet.

US Patent:

51571013, Oct 20, 1992

Filed:

Jun 4, 1990

Appl. No.:

7/532857

Inventors:

Robert B. Orr - Wilmington DE

Assignee:

Norwood Industries, Inc. - Malvern PA

International Classification:

C08G 1862

US Classification:

528 745

Abstract:

A pressure-sensitive adhesive prepared from a two-package polyurethane system; the two packages comprise an isocyanate reactant and an active hydrogen reactant. The reactants are characterized by a molar insufficiency of isocyanate and at least some tri- or higher-functionality in either the active hydrogen or the isocyanate reactant, or both. The underindexing should range from 0. 4 to 0. 75 when the higher functionality reactant has a functionality of 2. 1, and should range from 0. 3 to 0. 7 when the higher functionality reactant has a functionality of 4, with linearly extrapolated values in between. Pressure sensitive adhesives prepared from this system provide comparable shear resistance as do solvent-system polyurethane adhesives, without the worksite and environmental problems associated with such solvent systems.

US Patent:

52682285, Dec 7, 1993

Filed:

Sep 21, 1992

Appl. No.:

7/948209

Inventors:

Robert B. Orr - Wilmington DE

Assignee:

Norwood Industries, Inc. - Frazer PA

International Classification:

B32B 900

US Classification:

428343

Abstract:

A double-sided adhesive-coated foam tape particularly for bonding two adjacent rigid surfaces in which fine grooves on one or both sides of the tape facilitate air venting to minimize non-contact areas. The tape is used by affixing one side of the tape--the non-grooved side if only one side of the tape is grooved--to a first rigid surface to be adhered, removing the release liner from the grooved tape surface and pressing onto the grooved tape the second rigid surface intended for bonding. The grooves in the tape are fine enough that, once the two surfaces to be bonded are in position, the grooves largely or completely disappear.

US Patent:

20200115696, Apr 16, 2020

Filed:

May 23, 2018

Appl. No.:

16/616041

Inventors:

- Redwood City CA, US
Christopher Michael Micklitsch - Philadelphia PA, US
Oscar Alvizo - Fremont CA, US
Jovana Nazor - Milpitas CA, US
Da Duan - Newark CA, US
Judy Victoria Antonio Viduya - South San Francisco CA, US
Stephan Jenne - Foster City CA, US
Chihui An - Scotch Plains NJ, US
Keith Allen Canada - Freehold NJ, US
Paul N. Devine - Tinton Falls NJ, US
Iman Farasat - Rahway NJ, US
Anna Fryszkowska - New York NY, US
Katrina W. Lexa - Santa Rosa CA, US
Robert Kevin Orr - Cranford NJ, US

International Classification:

C12N 9/84

Abstract:

The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

US Patent:

20160145256, May 26, 2016

Filed:

Feb 1, 2016

Appl. No.:

15/012422

Inventors:

- Miami FL, US
Gerald Werne - Ketsch, DE
Xiaoyong Fu - Edison NJ, US
Robert K. Orr - Cranford NJ, US
Frank Xing Chen - Plainsboro NJ, US
Jian Cui - Edison NJ, US
Victoria M. Sprague - Bridgewater NJ, US
Fucheng Zhang - Edison NJ, US
Ji Xie - Edison NJ, US
Liansheng Zeng - Union NJ, US
Louis Peter Castellanos - Union City NJ, US
Yuyin Chen - Garwood NJ, US
Marc Poirier - Stewartsville NJ, US
Ingrid Mergelsberg - Mahwah NJ, US

International Classification:

C07D 471/10
C07D 207/267
C07C 217/46
C07D 498/04
C07D 207/28

Abstract:

This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

Author:

Robert J. Orr

ISBN #:

0335211704

Author:

Robert J. Orr

ISBN #:

0335211712

Author:

Robert Thomas Orr

ISBN #:

0025939602

Author:

Robert Thomas Orr

ISBN #:

0030579597

Author:

Robert Thomas Orr

ISBN #:

0721670172

Author:

Robert Thomas Orr

ISBN #:

0721670180

Author:

Robert Thomas Orr

ISBN #:

0883655578

Author:

Robert C. Orr

ISBN #:

0521581850