Robert A Dickson

Author:

Robert Dickson

ISBN #:

0792317483

Author:

Robert Dickson

ISBN #:

0920814883

Author:

Robert Dickson

ISBN #:

2894230664

Author:

Robert Gary Dickson

ISBN #:

0889082138

Author:

Robert A. Dickson

ISBN #:

0407017917

Author:

Robert A. Dickson

ISBN #:

0443039224

Author:

Robert A. Dickson

ISBN #:

0723607400

Author:

Robert G. Dickson

ISBN #:

8427116772

US Patent:

6677377, Jan 13, 2004

Filed:

Jun 21, 2001

Appl. No.:

09/885295

Inventors:

Robert B. Dickson - Kensington MD
Shaomeng Wang - Rockville MD
Istvan Enyedy - Hamden CT
Sheau-Ling Lee - Falls Church VA

Assignee:

Georgetown University School of Medicine - Washington DC

International Classification:

A61K 31155

US Classification:

514636

Abstract:

The present invention relates to a method of inhibiting carcinoma progression wherein matriptase plays a role in a subject in need of such inhibition including administering to a subject an effective amount of a compound comprising two positively charged groups, which are the same or different. The groups are linked by a chemical group having a length of between 5 and 30 A, and preferably between 15 and 24 A. Diagnostic methods based on matriptase action and therapeutic methods involving inhibition of matriptase activity are provided.

US Patent:

7355015, Apr 8, 2008

Filed:

Mar 10, 2000

Appl. No.:

09/936333

Inventors:

Robert B. Dickson - Silver Spring MD, US
Michael Johnson - Rockville MD, US
Shaomeng Wang - Rockville MD, US
Istvan Enyedy - Mount Ranier MD, US

Assignee:

Georgetown University School of Medicine - Washington DC

International Classification:

C07K 16/00
C07K 16/40
A61K 38/43

US Classification:

53038826, 5303871, 5303879, 5303881, 424 941

Abstract:

The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directed to a method of treating malignancies, which have the phenotype of matriptase production by administering a tumor formation inhibiting effective amount of concentrate of Bowman-Birk inhibitor (BBIC), or other matriptase inhibitor. The invention also is directed to nucleic acids encoding a matriptase protein or fragments thereof, and their use for structure elucidation and modeling to identify other inhibitors of matriptase, as well as to methods of identifying matriptase modulating agents, including activators and inhibitors.

US Patent:

7371776, May 13, 2008

Filed:

Jan 29, 2005

Appl. No.:

11/045947

Inventors:

Danica Ramljak - McLean VA, US
Robert B. Dickson - Kensington MD, US

Assignee:

Mars, Incorporated - McLean VA

International Classification:

A61K 31/35

US Classification:

514456009

Abstract:

This invention relates to methods of inducing dephosphorylation of a hyperphosphorylated cell cycle regulatory protein in a tumor cell in which hyperphosphorylation of said protein contributed to cell transformation, the method comprising contacting the tumor cell with a procyanidin oligomer of five monomeric units connected via a C-4→C-8 linkage. Examples of such compounds are [EC-(4β→8)]-EC, and [EC-(4β→8)]-EC-(4β→8)-C, wherein EC is epicatcchin and C is catechin.

US Patent:

7960163, Jun 14, 2011

Filed:

Feb 29, 2008

Appl. No.:

12/040467

Inventors:

Robert B. Dickson - Silver Spring MD, US
Michael Johnson - Rockville MD, US
Shaomeng Wang - Saline MI, US
Istvan Enyedy - Hamden CT, US

Assignee:

Georgetown University School of Medicine - Washington DC

International Classification:

C12N 9/00
C12N 9/50
C12N 1/20
C12N 15/00
C07H 21/04

US Classification:

435219, 435183, 4352523, 4353201, 536 232

Abstract:

The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directed to a method of treating malignancies, which have the phenotype of matriptase production by administering a tumor formation inhibiting effective amount of concentrate of Bowman-Birk inhibitor (BBIC), or other matriptase inhibitor. The invention also is directed to nucleic acids encoding a matriptase protein or fragments thereof, and their use for structure elucidation and modeling to identify other inhibitors of matriptase, as well as to methods of identifying matriptase modulating agents, including activators and inhibitors.

US Patent:

8156602, Apr 17, 2012

Filed:

Oct 13, 2006

Appl. No.:

11/549497

Inventors:

Eduardo J. Jimenez - Manalapan NJ, US
Robert Dickson - Belle Mead NJ, US
Douglas J. Hohlbein - Pennington NJ, US
Heng Cai - Skillman NJ, US
Sharon Kennedy - Randallstown MD, US
Thomas Mintel - Rahway NJ, US
Bruce M. Russell - Howell NJ, US

Assignee:

Colgate-Palmolive Company - New York NY

International Classification:

A46B 9/04

US Classification:

151671

Abstract:

A device for generating a chemical agent in situ on an as-needed basis via the application of an electrical potential across a pair of conductors in communication with an electrolyte. The device may be a toothbrush that generates chemical agents in a user's mouth by applying an electrical potential to an electrolyte such as saliva and/or a dentifrice located therein. The chemical agents may include ozone, hydrogen peroxide, peroxide, chlorine and/or hypochlorite. The toothbrush may include a voltage source and a first set of electrodes for applying an electrical potential to the electrolyte. The toothbrush may also include a second set of electrodes disposed about an anode of the first set of electrodes. The first and second sets of anodes cooperate to produce ions, peroxides, ozone and/or other chemical agents via the application of electrical potential to the electrolyte.

US Patent:

20030170245, Sep 11, 2003

Filed:

Mar 5, 2002

Appl. No.:

10/087987

Inventors:

Robert Dickson - Kensington MD, US
Christelle Benaud - Grenoble, FR
Michael Oberst - Chevy Chase MD, US

International Classification:

A61K039/395
G01N033/574

US Classification:

424/155100, 435/007230

Abstract:

The present invention provides an in vitro method of diagnosing the presence of a pre-malignant lesion, a malignancy, or other pathologic condition, in a subject, which is characterized by the presence of activated matriptase including the steps of: (A) obtaining a biological sample from a subject that is to be tested for a pre-malignant lesion, a malignancy, or other pathologic condition; B) exposing the biological sample to a detectable agent which recognizes and binds to activated matriptase; and (D) determining whether said detectable agent is bound to the biological sample. Preferably, the detectable agent is an antibody which specifically binds to activated matriptase. More preferably the antibody is selected from M69 and M123. The invention also provides a method of treating malignancies, pre-malignant conditions, and pathologic conditions in a subject which are characterized by the activated form of matriptase including administering a therapeutically effective amount of an agent capable of blocking the activity of active matriptase.

US Patent:

20120189986, Jul 26, 2012

Filed:

Mar 30, 2012

Appl. No.:

13/435726

Inventors:

Eduardo J. Jimenez - Manalapan NJ, US
Robert Dickson - Silver Bay NY, US
Douglas J. Hohlbein - Hopewell NJ, US
Heng Cai - Skillman NJ, US
Sharon Kennedy - Randallstown MD, US
Thomas Mintel - Rahway NJ, US
Bruce M. Russell - Howell NJ, US

Assignee:

Colgate-Palmolive Company - New York NY

International Classification:

A61C 17/00

US Classification:

433216

Abstract:

A method of cleaning teeth by providing a device for generating a chemical agent in situ on an as-needed basis via the application of an electrical potential across a pair of conductors in communication with an electrolyte. The chemical agents may include ozone, hydrogen peroxide, peroxide, chlorine and/or hypochlorite. The device may include a voltage source and a first set of electrodes for applying an electrical potential to the electrolyte. The device may also include a second set of electrodes disposed about an anode of the first set of electrodes. The first and second sets of anodes cooperate to produce ions, peroxides, ozone and/or other chemical agents via the application of electrical potential to the electrolyte.

US Patent:

54828481, Jan 9, 1996

Filed:

Feb 22, 1994

Appl. No.:

8/199792

Inventors:

Robert B. Dickson - Silver Spring MD
Yuenian E. Shi - Roslyn Heights NY

Assignee:

Georgetown University - Washington DC

International Classification:

C12N 950
C12N 996

US Classification:

435219

Abstract:

An 80 kDa metaloproteinase is found in hormone-dependent human breast cancer cells. The enzyme is active in the presence of calcium, manganese, or magnesium ions. The 80 kDa proteinase is useful for evaluating therapeutic progress and in formulating plans for treatment.