Michael W Keating

Author:

Michael Keating

ISBN #:

0198274769

Author:

Michael Keating

ISBN #:

0198761872

Author:

Michael Keating

ISBN #:

0199240760

Author:

Michael Keating

ISBN #:

0199242143

Author:

Michael Keating

ISBN #:

0199275343

Author:

Michael Keating

ISBN #:

0080364128

Author:

Michael Keating

ISBN #:

0312158173

Author:

Michael Keating

ISBN #:

0333265963

US Patent:

7622306, Nov 24, 2009

Filed:

Apr 20, 2005

Appl. No.:

11/110374

Inventors:

Maher Albitar - Coto de Caza CA, US
Elihu H. Estey - Houston TX, US
Hagop M. Kantarjian - Bellaire TX, US
Francis J. Giles - Bellaire TX, US
Michael J. Keating - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

G01N 24/00
G01N 1/00
G01N 1/10
G01N 33/48
G01N 33/00
A61K 49/00
A01N 61/00
A61K 31/00

US Classification:

436173, 473174, 473179, 473 63, 473 64, 473 86, 424 91, 424 92, 514 1

Abstract:

The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies.

US Patent:

8097468, Jan 17, 2012

Filed:

Oct 21, 2009

Appl. No.:

12/582998

Inventors:

Maher Albitar - Coto de Caza CA, US
Elihu H. Estey - Houston TX, US
Hagop M. Kantarjian - Bellaire TX, US
Francis J. Giles - Bellaire TX, US
Michael J. Keating - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

G01N 24/00
G01N 1/00
G01N 1/10
G01N 33/00
G01N 33/48
A61K 49/00
A61K 31/00
A01N 61/00

US Classification:

436173, 436 63, 436 64, 436 86, 436174, 436179, 424 91, 424 92, 514 1

Abstract:

The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies.

US Patent:

8104915, Jan 31, 2012

Filed:

May 18, 2009

Appl. No.:

12/467828

Inventors:

Ralph Osterhout - San Francisco CA, US
Michael J Keating - Hardwick NJ, US
Antony Van der Mude - Hackettstown NJ, US

Assignee:

Osterhout Design Group - San Francisco CA

International Classification:

F21L 4/04

US Classification:

362202, 362200, 362208

Abstract:

A flashlight includes a light powered by a battery, and a circuit having: a memory for storing a battery life information and voltage output information versus time for the battery to power the light, a controller operating a count down timer to accumulate an amount of time that the battery powers the light, a voltage measure circuit for monitoring the voltage output by the battery while the battery powers the light and supply the voltage output to the controller. The controller determines: a first remaining battery life by comparing the accumulated time to the battery life, a second remaining battery life by comparing the voltage output to the voltage output information, and the lesser of the first and second remaining battery lives. The flashlight includes a display for receiving a command from the controller to display the lesser of the first remaining battery life and the second remaining battery life.

US Patent:

8463565, Jun 11, 2013

Filed:

Dec 23, 2011

Appl. No.:

13/336796

Inventors:

Ralph Osterhout - San Francisco CA, US
Michael J. Keating - Hardwick NJ, US
Antony Van der Mude - Hacketstown NJ, US

Assignee:

Osterhout Design Group - San Francisco CA

International Classification:

G01R 31/36

US Classification:

702 63, 320118, 320131, 320149, 320150

Abstract:

A flashlight includes a light powered by a battery, and a circuit having: a memory for storing a battery life information and voltage output information versus time for the battery to power the light, a controller operating a count down timer to accumulate an amount of time that the battery powers the light, a voltage measure circuit for monitoring the voltage output by the battery while the battery powers the light and supply the voltage output to the controller. The controller determines: a first remaining battery life by comparing the accumulated time to the battery life, a second remaining battery life by comparing the voltage output to the voltage output information, and the lesser of the first and second remaining battery lives. The flashlight includes a display for receiving a command from the controller to display the lesser of the first remaining battery life and the second remaining battery life.

US Patent:

8563323, Oct 22, 2013

Filed:

Dec 14, 2011

Appl. No.:

13/325986

Inventors:

Maher Albitar - Coto de Caza CA, US
Elihu H. Estey - Houston TX, US
Hagop M. Kantarjian - Bellaire TX, US
Francis J. Giles - Bellaire TX, US
Michael J. Keating - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

G01N 1/00
G01N 1/10
G01N 24/00
G01N 33/00
G01N 33/48
A61K 31/00
A61K 49/00
A01N 61/00

US Classification:

436173, 436 63, 436 64, 436 86, 436174, 436179, 424 91, 424 92, 514 1

Abstract:

The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies.