Michael C Chang

US Patent:

6631990, Oct 14, 2003

Filed:

Dec 19, 2001

Appl. No.:

10/024851

Inventors:

Manfred A. Schippert - Chelmsford MA
Michael A. Chang - Weston MA
Oscar K. Hollander - Falmouth MA
Sheldon H. Moll - Bedford MA

Assignee:

Acmed, Inc. - Bedford MA

International Classification:

A61B 310

US Classification:

351214

Abstract:

A measurement system is provided for measuring distances in the anterior chamber of an eye in conjunction with a slit lamp ophthalmologic microscope table. The measurement system includes a linearly movable interface assembly operative to pick up motions of the microscope assembly in a direction along an optical axis of the eye. A linear measurement assembly is coupled to the interface assembly and operative to determine a distance traveled by the interface. The measurement system may further be provided with a three-axis motion assembly and an optical microscope assembly mounted on the motion assembly. An image recording device is optically aligned with the optical microscope assembly to record images from the optical microscope assembly. A controller assembly is operative to control motion of the three-axis motion assembly in a first horizontal direction parallel to an optical axis of an eye of a patient, in a second horizontal direction orthogonal to the first horizontal direction to align the microscope assembly with both eyes, and in a vertical direction. The measurement system with image recording capability may be a stand-along system or incorporated for engagement and disengagement with an existing slit lamp table.

US Patent:

51324636, Jul 21, 1992

Filed:

Jun 12, 1991

Appl. No.:

7/713895

Inventors:

Donald W. Graham - Mountainside NJ
John C. Chabala - Westfield NJ
Tesfaye Biftu - Parlin NJ
Michael N. Chang - Newtown PA
Yuan-Ching P. Chiang - Piscataway NJ
Shu S. Yang - Bridgewater NJ
Kathryn L. Thompson - Westfield NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07C31714
C07C31722

US Classification:

568 33

Abstract:

Novel 1,3-Diaryl cyclopentanes of the following general formula were prepared. ##STR1## These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or disorders mediated by the PAF, for example, hypotension, inflammation, nephritis, stroke and other cardiovascular disorders, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.

US Patent:

49201069, Apr 24, 1990

Filed:

Aug 1, 1989

Appl. No.:

7/388716

Inventors:

Michael N. Chang - Westfield NJ
Yuan-Ching P. Chiang - Piscataway NJ
James V. Heck - Scotch Plains NJ
Michael D. Lewis - Rahway NJ
Shu S. Yang - Bridgewater NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31695
C07D31720

US Classification:

514 63

Abstract:

This invention relates to acetylenic cyclic carbonates that are useful in the treatment of fungal diseases and hypercholesterolemic conditions.

US Patent:

46862358, Aug 11, 1987

Filed:

Aug 12, 1985

Appl. No.:

6/764446

Inventors:

Michael N. Chang - Westfield NJ
Norman P. Jensen - Princeton NJ
Milton L. Hammond - Somerville NJ
Robert A. Zambias - Springfield NJ
John McDonald - Indianapolis IN
Kathleen M. Rupprecht - Cranford NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07C 3921
A61K 3105

US Classification:

514520

Abstract:

Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.

US Patent:

48472719, Jul 11, 1989

Filed:

Mar 4, 1987

Appl. No.:

7/021848

Inventors:

John C. Chabala - Westfield NJ
Yuan-Ching P. Chiang - Piscataway NJ
Michael N. Chang - Westfield NJ
Narindar M. Girotra - Parlin NJ
Donald W. Graham - Mountainside NJ
Shu S. Yang - Bridgewater NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31365
A61K 3144
C07D30512
C07D40512

US Classification:

514336

Abstract:

The compounds of the following general structural formula (I) ##STR1## are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.

US Patent:

48065641, Feb 21, 1989

Filed:

May 26, 1987

Appl. No.:

7/053774

Inventors:

John C. Chabala - Westfield NJ
Yuan-Ching P. Chiang - Piscataway NJ
Michael N. Chang - Westfield NJ
Donald W. Graham - Mountainside NJ
James V. Heck - Scotch Plains NJ
Shu S. Yang - Bridewater NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31365
C07D30508

US Classification:

514449

Abstract:

The compounds of the following structural formula (I) ##STR1## are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatmet of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.

US Patent:

47133937, Dec 15, 1987

Filed:

Apr 25, 1985

Appl. No.:

6/727317

Inventors:

Michael N. Chang - Westfield NJ
Kathryn L. Thompson - Westfield NJ
David A. Boulton - Edison NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3134
C07D30779

US Classification:

514469

Abstract:

Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a cinnamylhalide followed by reduction; or (2) by Wittig reaction involving a halomethyl derivative of 2,3-dihydrobenzofuran (or 2,3-dihydrobenzopyran and an aryl or a heteroaryl aldehyde followed by reduction. These compounds were found to be potent anti-inflammatory agents.

US Patent:

47756799, Oct 4, 1988

Filed:

May 4, 1987

Appl. No.:

7/045651

Inventors:

Michael N. Chang - Westfield NJ
David A. Boulton - Edison NJ
Kathryn L. Thompson - Westfield NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31415
C07D40506

US Classification:

514397

Abstract:

Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a cinnamylhalide followed by reduction; or (2) by Wittig reaction involving a halomethyl derivative of 2,3-dihydrobenzofuran (or 2,3-dihydrobenzopyran and an aryl or a heteroaryl aldehyde followed by reduction. These compounds were found to be potent anti-inflammatory agents.