Mark D Osborne

US Patent:

7826943, Nov 2, 2010

Filed:

Apr 2, 2007

Appl. No.:

11/695350

Inventors:

Lijie Yu - Clifton Park NY, US
Daniel Joseph Cleary - Schenectady NY, US
Mark David Osborne - Castleton NY, US

Assignee:

General Electric Company - Niskayuna NY

International Classification:

G01B 15/00
G06F 19/00

US Classification:

701 29, 701 34, 701 35, 702182, 702185

Abstract:

A method for diagnosing faults in a particular device within a fleet of devices is provided. The method comprises receiving performance data related to one or more parameters associated with a fleet of devices and processing the performance data to detect one or more trend shifts in the one or more parameters. The method then comprises detrending the one or more parameters to derive noise-adjusted performance data related to a particular parameter associated with a particular device. The method further comprises generating a fleet-based diagnostic model based on trend patterns and data characteristics associated with the fleet of devices. The fleet-based diagnostic model comprises one or more fuzzy rules defining one or more expected trend shift data ranges for the one or more parameters associated with the fleet of devices. The method then comprises computing one or more scaling factors for the particular parameter associated with the particular device and scaling the one or more of fuzzy rules defined for the one or more parameters in the fleet-based diagnostic model, based on the one or more scaling factors, to generate a personalized diagnostic model for the particular parameter associated with the particular device. The method finally comprises evaluating the personalized diagnostic model against the one or more trend shifts detected for the one or more parameters, to diagnose a fault associated with the particular device.

US Patent:

56374631, Jun 10, 1997

Filed:

May 4, 1995

Appl. No.:

8/434730

Inventors:

Stephen Dalton - Bloomfield NJ
Jarema P. Kochan - Verona NJ
Mark A. Osborne - South Brunswick NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C12Q 108
C12P 2100
C07K 100
C07H 2104

US Classification:

435 6

Abstract:

Methods are provided for studying protein-protein interactions which require posttranslational modification of one of the proteins. The interaction is detected by reconstituting the activity of a transcriptional activator. This activity is dependent on the interactions between three different proteins. These include two chimeric proteins, one of which must be posttranslationally modified by the activity of the third protein in order for the chimeric proteins to interact. One of the chimeric proteins contains a transcriptional activation domain fused to a test protein. The second chimeric protein contains a DNA-binding domain of a transcriptional activator fused to the other test protein.