Joseph V Rubino

US Patent:

8153768, Apr 10, 2012

Filed:

May 2, 2003

Appl. No.:

10/428894

Inventors:

Arthur Kunz - New City NY, US
Justin Keith Moran - Valley Cottage NY, US
Joseph Thomas Rubino - Towaco NJ, US
Neera Jain - New City NY, US
Eugene Joseph Vidunas - Middletown NY, US
John McLean Simpson - Upper Nyack NY, US
Paul David Robbins - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John Francis DiJoseph - Woodbridge NJ, US
Mark Edward Ruppen - Garnerville NY, US
Nitin Krishnaji Damle - Upper Saddle River NJ, US
Andrew George Popplewell - Staines, GB

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

C07K 16/00
C07K 17/00
C07K 16/28

US Classification:

5303911, 5303917, 5303919, 530409

Abstract:

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

US Patent:

20040192900, Sep 30, 2004

Filed:

Nov 3, 2003

Appl. No.:

10/699874

Inventors:

Arthur Kunz - New City NY, US
Justin Moran - Valley Cottage NY, US
Joseph Rubino - Towaco NJ, US
Neera Jain - New City NY, US
Eugene Vidunas - Middletown NY, US
John Simpson - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John DiJoseph - Woodbridge NJ, US
Mark Ruppen - Garnerville NY, US
Nitin Damle - Upper Saddle River NJ, US
Paul Robbins - Derwood MD, US
Andrew Popplewell - Staines, GB

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

C07K016/46
C07K014/47

US Classification:

530/391100, 530/403000, 530/409000

Abstract:

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

US Patent:

20060002942, Jan 5, 2006

Filed:

Mar 15, 2005

Appl. No.:

11/080587

Inventors:

Arthur Kunz - New City NY, US
Justin Moran - Valley Cottage NY, US
Joseph Rubino - Towaco NJ, US
Neera Jain - Monroe NY, US
Erwin Raymond Boghaert - Monroe NY, US
Philip Hamann - Thiells NY, US
Mark Ruppen - Garnerville NY, US
Nitin Damle - Upper Saddle River NJ, US
Eugene Vidunas - Middletown NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 39/395
C07K 16/46

US Classification:

424178100, 530391100

Abstract:

Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti-Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

US Patent:

20090105461, Apr 23, 2009

Filed:

Aug 4, 2008

Appl. No.:

12/221551

Inventors:

Arthur Kunz - New City NY, US
Justin Keith Moran - Valley Cottage NY, US
Joseph Thomas Rubino - Towaco NJ, US
Neera Jain - Lexington MA, US
Erwin Raymond Arsene Boghaert - Monroe NY, US
Philip Ross Hamann - Thiells NY, US
Mark Edward Ruppen - Garnerville NY, US
Nitin Krishnaji Damle - Upper Saddle River NJ, US
Eugene Vidunas - Middletown NY, US
Lyka Kalyandrug - Congers NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07K 16/00

US Classification:

5303919

Abstract:

Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti-Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

US Patent:

20180339058, Nov 29, 2018

Filed:

Jul 30, 2018

Appl. No.:

16/048511

Inventors:

- New York NY, US
Justin Keith Moran - Valley Cottage NY, US
Joseph Thomas Rubino - Towaco NJ, US
Neera Jain - New City NY, US
Eugene Joseph Vidunas - Middletown NY, US
John McLean Simpson - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John Francis Dijoseph - Woodbridge NJ, US
Mark Edward Ruppen - Garnerville NY, US
Nitin Krishnaji Damle - Upper Saddle River NJ, US
Paul David Robbins - Drewood MD, US
Andrew George Popplewell - Staines, GB

Assignee:

Wyeth Holdings LLC - New York NY

International Classification:

A61K 47/64
C07K 16/28
A61K 47/68

Abstract:

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

US Patent:

20160303252, Oct 20, 2016

Filed:

May 3, 2016

Appl. No.:

15/145238

Inventors:

- New York NY, US
Justin Keith Moran - Valley Cottage NY, US
Joseph Thomas Rubino - Towaco NJ, US
Neera Jain - New City NY, US
Eugene Joseph Vidunas - Middletown NY, US
John McLean Simpson - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John Francis Dijoseph - Woodbridge NJ, US
Mark Edward Ruppen - Garnerville NY, US
Nitin Krishnaji Damle - Upper Saddle River NJ, US
Paul David Robbins - Drewood MD, US
Andrew George Popplewell - Staines, GB

Assignee:

Wyeth Holdings LLC - New York NY

International Classification:

A61K 47/48
C07K 16/28

Abstract:

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

US Patent:

20140235835, Aug 21, 2014

Filed:

Mar 7, 2014

Appl. No.:

14/201184

Inventors:

- Madison NJ, US
Justin Keith Moran - Valley cottage NY, US
Joseph Thomas Rubino - Towaco NJ, US
Neera Jain - New City NY, US
Eugene Joseph Vidunas - Middletown NY, US
John McLean Simpson - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John Francis Dijoseph - Woodbridge NJ, US
Mark Edward Ruppen - Garnerville NY, US
Nitin Krishnaji Damle - Upper Saddle River NJ, US
Paul David Robbins - Drewood MD, US
Andrew George Popplewell - Staines, GB

Assignee:

WYETH HOLDINGS LLC - Madison NY

International Classification:

A61K 47/48
A61K 31/704

US Classification:

5303919, 5303917

Abstract:

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

US Patent:

20140212361, Jul 31, 2014

Filed:

May 18, 2012

Appl. No.:

14/122414

Inventors:

Mohammad Khalid Ijaz - New Milford NJ, US
Joseph Rubino - Parsippany NJ, US
Yun-Peng Zhu - Fairlawn NJ, US

Assignee:

Reckitt Benckiser LLC - Parsippany NJ

International Classification:

A01N 59/20
A01N 37/02
A01N 25/02
A01N 31/02

US Classification:

424 45

Abstract:

Sprayable, pressurized inanimate surface and air liquid treatment compositions comprise (or in certain preferred embodiments may consist essentially of, or may consist of): a copper source material which releases copper ions into the treatment composition, at least one alcohol which independently of other constituents present exhibits a microbicidal effect, at least one quaternary ammonium compound which provides a microbicidal benefit, propellant, water, optionally but very preferably at least one detersive surfactant, further optionally one or more further constituents which impart one or more advantageous technical or aesthetic benefits to the compositions, wherein the compositions are at a pH such that the surface treatment compositions, exhibit a microbicidal or germicidal or antimicrobial effect on treated inanimate surfaces or when used to treat an airspace, e.g. ambient air, characterized in exhibiting a microbicidal benefit when tested against one or more challenge microorganisms, preferably against Poliovirus type 1 Sabin (“PV1”), according to one or more of the following standardized test protocols: ASTM E1052-96(2002) Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension, or ASTM E1053-11 Standard Test Method to Assess Virucidal Activity of Chemicals Intended for Disinfection of Inanimate, Nonporous Environmental Surfaces, or European Standard Surface Test, EN13697, or AOAC Germicidal Spray Products as Disinfectant Test Method, AOAC Index, 17Ed. (2000).