James M Mills

US Patent:

7879551, Feb 1, 2011

Filed:

Dec 17, 2007

Appl. No.:

11/958126

Inventors:

Lawrence C. Brody - Baltimore MD, US
Anne Parle-McDermott - Dublin, IE
John Scott - Dublin, IE
Peadar Kirke - Dublin, IE
James Mills - Rockville MD, US
Faith Pangilinan - Rockville MD, US
Anne Molloy - Dublin, IE

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC
The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin - Dublin
The Health Research Board - Dublin

International Classification:

C07H 21/04
C12Q 1/68

US Classification:

435 6, 435 911, 435 912, 536 231, 536 243

Abstract:

The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTHFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.

US Patent:

20110177958, Jul 21, 2011

Filed:

Jan 18, 2011

Appl. No.:

13/008528

Inventors:

Lawrence C. BRODY - Baltimore MD, US
Anne PARLE-MCDERMOTT - Dublin, IE
John SCOTT - Dublin, IE
Peadar KIRKE - Dublin, IE
James MILLS - Rockville MD, US
Faith PANGILINAN - Rockville MD, US
Anne MOLLOY - Dublin, IE

Assignee:

The United States of America, as represented by Secretary, Department of Health and Human Services - Bethesda MD
The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth - Dublin
The Health Research Board - Dublin

International Classification:

C40B 30/00
C12Q 1/68
G01N 33/573
H01J 49/26

US Classification:

506 7, 435 618, 435 611, 435 612, 435 71, 250282

Abstract:

The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTHFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.