Gunvant N Mehta

US Patent:

41736265, Nov 6, 1979

Filed:

Dec 11, 1978

Appl. No.:

5/968608

Inventors:

Robert E. Dempski - Dresher PA
Gunvant N. Mehta - Lansdale PA
Joseph C. Saboe - Norristown PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 922
A61K 948

US Classification:

424 19

Abstract:

A sustained release indomethacin pharmaceutical product is provided that utilizes a pellet formulation encapsulated in a hard gelatin capsule. A portion of the pellets is uncoated for immediate and rapid release of indomethacin for elevating the plasma level. The remainder of the pellets are coated with a polymer to sustain the plasma level. The uncoated and coated pellets may be mixed with non-medicated pellets as a capsule filler.

US Patent:

41794974, Dec 18, 1979

Filed:

Nov 13, 1978

Appl. No.:

5/959550

Inventors:

Edward M. Cohen - Beaumont, FR
Wayne M. Grim - Doylestown PA
Richard J. Harwood - Philadelphia PA
Gunvant N. Mehta - Lansdale PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 922
A61K 926

US Classification:

424 22

Abstract:

Solid unit dosage medicaments which are suitable for use in animals and humans are prepared with hydroxypropyl cellulose as the primary formulating excipient. These medicaments are particularly suitable for ophthalmic use since they are slowly but completely water soluble when they are inserted in the cul-de-sac of the eye and thus provide for a convenient means of prolonged treatment of the eye with concomitant reduced dosing frequency.

US Patent:

50267094, Jun 25, 1991

Filed:

Jun 7, 1988

Appl. No.:

7/203435

Inventors:

Richard J. Harwood - Bensalem PA
Gunvant N. Mehta - Lansdale PA
Ramesh C. Jhawar - Yardley PA
Liang-Lii Huang - Maple Glen PA
Wayne M. Grim - Doylestown PA
Shun P. Li - Upper Darby PA

Assignee:

Rorer Pharmaceutical Corporation - Fort Washington PA

International Classification:

A01N 4390
A01K 3152

US Classification:

514263

Abstract:

A method for the preparation of a sustained release pharmaceutical composition comprising forming a fluidized ring of said particles and contacting said particles maintained suspended in said ring with a liquid composition containing a pharmaceutically active material and an alkali-soluble material.

US Patent:

48569097, Aug 15, 1989

Filed:

Jun 23, 1986

Appl. No.:

6/877146

Inventors:

Gunvant N. Mehta - Bensalem PA
Dennis J. Wertan - Philadelphia PA
Wayne M. Grim - Doylestown PA

Assignee:

Rorer Pharmaceutical Corporation - Fort Washington PA

International Classification:

B01F 100

US Classification:

366208

Abstract:

Standardized tests of the dissolution rates of pharmacologic dosage units such as salicylic acid tablets, for example, are conducted by placing the dosage unit in a liquid-permeable cylindrical wire basket and rotating the basket in the solvent about two different axes, preferably one vertical axis and one horizontal axis. The apparatus comprises an outer vertical tube to which the basket is mounted off center from the vertical axis of the tube so that it orbits around the vertical axis when the vertical outer tube is rotated; the basket is mounted on a horizontal shaft which can rotate about its horizontal axis. An inner shaft extends vertically through the outer vertical shaft, and bevel gears are provided between the horizontal shaft and the inner vertical shaft so that relative rotation of the upper ends of the inner and outer vertical shafts with respect to each other about their axes causes the basket to rotate about the horizontal shaft axis. By holding the inner shaft stationary and rotating the outer shaft, the desired two-axis motion of the basket is produced.