Frank W Mills

Author:

Frank Mills

ISBN #:

1933428228

US Patent:

51570483, Oct 20, 1992

Filed:

Nov 12, 1991

Appl. No.:

7/790042

Inventors:

Frank D. Mills - Highland MD
Richard T. Brown - Silver Spring MD
Giles D. Mills - Laurel MD

Assignee:

The United States of America, as represented by the Secretary of
Agriculture - Washington DC

International Classification:

A61K 3134
A61K 3122
C07D30742
C07C 69527

US Classification:

514461

Abstract:

An improved method for the decarbalkoxyation of alkylated. beta. -keto esters to obtain high yields of ketones. In accordance with the method, decarbalkoxylation of alkylated. beta. -keto esters is accomplished by heating the esters in the presence of dilute aqueous alkali and an effective amount of a phase-transfer agent. The method produces commercially practical yields of ketone in a manner which is facile, economical and environmentally safe. Novel methylene-linked pyrethroid ketones produced from the improved method exhibit insecticidal activity against various agricultural pests.

US Patent:

48290912, May 9, 1989

Filed:

May 27, 1987

Appl. No.:

7/055265

Inventors:

Frank D. Mills - Highland MD
Richard T. Brown - Silver Spring MD
Giles D. Mills - Laurel MD

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

A61K 3112

US Classification:

514684

Abstract:

An improved method for the decarbalkoxylation of alkylated. beta. -keto esters to obtain high yields of ketones. In accordane with the method, decarbalkoxylation of alkylated. beta. -keto esters is accomplished by heating the esters in the presence of dilute aqueous alkali and an effective amount of a phase-transfer agent. The method produces commercially practical yields of ketone in a manner which is facile, economical and environmentally safe. Novel methylene-linked pyrethroid ketones produced from the improved method exhibit insecticidal activity against various agricultural pests.

US Patent:

52741362, Dec 28, 1993

Filed:

Jul 1, 1992

Appl. No.:

7/907342

Inventors:

Frank D. Mills - Highland MD
Richard T. Brown - Silver Spring MD
Giles D. Mills - Laurel MD

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C07C 4565
C07D30746

US Classification:

549498

Abstract:

An improved method for the decarbalkoxylation of alkylated. beta. -keto esters to obtain high yields of ketones. In accordance with the method, decarbalkoxylation of alkylated. beta. -keto esters is accomplished by heating the esters in the presence of dilute aqueous alkali and an effective amount of a phase-transfer agent. The method produces commercially practical yields of ketone in a manner which is facile, economical and environmentally safe. Novel methylene-linked pyrethroid ketones produced from the improved method exhibit insecticidal activity against various agricultural pests.