Thomas J. Hosted - Summit NJ, US Jason S. Simon - Westfield NJ, US Marc M. Delorenzo - East Hanover NJ, US Donna Marie Carr - Kenilworth NJ, US William T. Windsor - East Brunswick NJ, US Ahmed A. Samatar - West Windsor NJ, US
International Classification:
A61K 38/21 C12Q 1/68 A61P 35/00
US Classification:
424 857, 435 612
Abstract:
The present invention provides, inter alia, methods for predicting the sensitivity of a disease, such as cancer, to an ERK1 or ERK2 or MEK inhibitor by detecting the presence of an allele of BRAF in cells mediating the disease. Methods of treatment are also provided.