Daniel R Sweeney

US Patent:

48351822, May 30, 1989

Filed:

Aug 21, 1987

Appl. No.:

7/088982

Inventors:

Nigel H. Greig - Washington DC
Daniel J. Sweeney - Indianapolis IN
Stanley I. Rapoport - Washington DC

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

A61K 31245
C07C10164

US Classification:

514538

Abstract:

Tertiary butyl esters of anticancer drugs are provided which have the following formula: ##STR1## wherein R. sub. 1 and R. sub. 2 are the same or different and are selected from the group consisting of H, F, Cl, Br, and I and R. sub. 2 can also be NH. sub. 2 ; R. sub. 3, R. sub. 4, and R. sub. 5 are the same or different and are selected from the group consisting of H, F, Cl, Br, I, and C. sub. 1 -C. sub. 3 alkyl; wherein alkyl may be substituted with F, Cl, Br, or I, with the proviso that at least two of R. sub. 3, R. sub. 4, and R. sub. 5 are alkyl or substituted alkyl; and n=0-4. The compounds of the present invention can be used in treating cancer by significantly increasing the brain levels of the drugs of the invention and their active metabolites.

US Patent:

53724143, Dec 13, 1994

Filed:

Nov 25, 1992

Appl. No.:

7/981830

Inventors:

Nicholas E. Lamonakis - Concord MA
Daniel G. Sweeney - Bolton MA

International Classification:

A47K 1000

US Classification:

312 3

Abstract:

A towel and towel holder combination for outdoor use in sports provides the user with a dry towel in spite of falling rain and water impinging against the holder includes a substantially upright towel holder that is closed at the top and open at the bottom and provides a protected space within for containing a towel to which there is access through the open end, the towel being attached to the holder and contained in the protected space, the holder being made of flexible water repelling material and the towel being water absorbent material on the inside of the holder so that when it is turned inside-out, the towel is exposed for use.

US Patent:

20160361109, Dec 15, 2016

Filed:

Jun 10, 2016

Appl. No.:

15/179310

Inventors:

- Cambridge MA, US
- Blacksburg VA, US
Thiruvallur R. Gowrishankar - Acton MA, US
Daniel C. Sweeney - Blacksburg VA, US
Rafael V. Davalos - Blacksburg VA, US

International Classification:

A61B 18/14
A61N 1/30

Abstract:

The invention encompasses a method of inducing a high permeability state in a cell membrane and a method for ablating a target tissue wherein the method comprises applying an electroporation pulse to a cell, wherein at a time after the electroporation pulse is applied, a plurality of long lived pores (LLPs) are formed in the cell membrane and the presence of the LLPs causes a change in the cell osmotic pressure difference. The invention also encompasses a method for ablating a target tissue using an electrical pulse regime that induces cell permeabilization and cell death, wherein the primary mechanism of cell death is as a result of electroporation.

Author:

Daniel Sweeney

ISBN #:

0830606289

Author:

Daniel Sweeney

ISBN #:

0830627286

Author:

Daniel Sweeney

ISBN #:

0935149392

Author:

Daniel S. Sweeney

ISBN #:

0765703815

Author:

Daniel S. Sweeney

ISBN #:

0842303073

Author:

Daniel S. Sweeney

ISBN #:

0787948071

Author:

Daniel J. Sweeney

ISBN #:

0471057177

Author:

Daniel J. Sweeney

ISBN #:

0471850942