Andrew F Myers

US Patent:

6809099, Oct 26, 2004

Filed:

Nov 5, 2001

Appl. No.:

10/011466

Inventors:

Andrew G. Myers - Boston MA
Alleyn T. Plowright - Didsbury, GB
Daniel W. Kung - Salem CT
Brian Lanman - Cambridge MA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 314985

US Classification:

514250, 544342

Abstract:

In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I), and methods for the synthesis thereof. In another aspect, the present invention provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. In yet another aspect, the present invention provides methods for treating cancer comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof.

US Patent:

6887517, May 3, 2005

Filed:

Jun 12, 2002

Appl. No.:

10/171422

Inventors:

Ronald Lee Cook - Lakewood CO, US
Brian John Elliott - Superior CO, US
Silvia DeVito Luebben - Golden CO, US
Andrew William Myers - Arvada CO, US
Bryan Matthew Smith - Boulder CO, US

Assignee:

TDA Research - Wheat Ridge CO

International Classification:

B05D001/36
B32B001/00

US Classification:

427214, 427215, 427220, 428402, 428403, 428404, 428407

Abstract:

A new class of surface modified particles and a multi-step Michael-type addition surface modification process for the preparation of the same is provided. The multi-step Michael-type addition surface modification process involves two or more reactions to compatibilize particles with various host systems and/or to provide the particles with particular chemical reactivities. The initial step comprises the attachment of a small organic compound to the surface of the inorganic particle. The subsequent steps attach additional compounds to the previously attached organic compounds through reactive organic linking groups. Specifically, these reactive groups are activated carbon—carbon pi bonds and carbon and non-carbon nucleophiles that react via Michael or Michael-type additions.

US Patent:

6986943, Jan 17, 2006

Filed:

Jun 12, 2002

Appl. No.:

10/171402

Inventors:

Ronald Lee Cook - Lakewood CO, US
Brian John Elliott - Superior CO, US
Silvia DeVito Luebben - Golden CO, US
Andrew William Myers - Arvada CO, US
Bryan Matthew Smith - Boulder CO, US

Assignee:

TDA Research, Inc. - Wheat Ridge CO

International Classification:

B05D 1/36
B32B 1/00

US Classification:

428402, 428403, 428404, 427214, 427215

Abstract:

The present invention relates to a new class of surface modified particles and to a multi-step surface modification process for the preparation of the same. The multi-step surface functionalization process involves two or more reactions to produce particles that are compatible with various host systems and/or to provide the particles with particular chemical reactivities. The initial step comprises the attachment of a small organic compound to the surface of the inorganic particle. The subsequent steps attach additional compounds to the previously attached organic compounds through organic linking groups.

US Patent:

7065187, Jun 20, 2006

Filed:

Jan 10, 2002

Appl. No.:

10/041571

Inventors:

Andrew Myers - Wayland MA, US
Srinivasa Rao Kolaparthi - North Chelmsford MA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

H04M 1/64

US Classification:

379 8822, 379 8811

Abstract:

A system and method for enabling annotation of audible voice messages in a unified communication services (UCS) system. In some embodiments, subscribers access a message presentation form that enables simultaneous playback and annotation of audible voice messages.

US Patent:

7122549, Oct 17, 2006

Filed:

Apr 16, 2004

Appl. No.:

10/826859

Inventors:

Andrew G. Myers - Boston MA, US
Alleyn T. Plowright - Manchester, GB

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 31/4985
C07O 471/18

US Classification:

514250, 544342

Abstract:

In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I), and methods for the synthesis thereof. In another aspect, the present invention provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. In yet another aspect, the present invention provides methods for treating cancer comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof.

US Patent:

7143417, Nov 28, 2006

Filed:

Jan 10, 2002

Appl. No.:

10/041570

Inventors:

Andrew Myers - Wayland MA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 9/44

US Classification:

719318, 719312, 709213

Abstract:

A system and method for providing notification of significant events such as received or disposed of messages in a unified communication services network. Notifications are event based and may be filtered according to predetermined criteria. One or more event managers may, among other things, manage the receipt and dispersal of event notifications and pass the notifications to one or more notification handlers for dispersal of the notifications to subscribers.

US Patent:

7183054, Feb 27, 2007

Filed:

Jun 3, 2003

Appl. No.:

10/453243

Inventors:

Andrew G. Myers - Boston MA, US
Jacob R. LaPorte - Cambridge MA, US
Chengguo Xing - Minneapolis MN, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q 1/68
C12Q 1/70
G01N 33/53
C07H 21/00
A61K 31/70
A61K 38/00
A01N 61/00

US Classification:

435 6, 536 231, 536 243, 530300, 514 1, 514 44, 435 5, 435 71, 435 72

Abstract:

The present invention provides methods and systems for the identification of a biological target of a chemical compound, such as saframycin A, known to bind a polynucleotide. The invention also provides methods of screening chemical compounds for those which act in a similar method and may be more potent than known compounds. The inventive methods are particularly useful in the high-throughput screening of chemical compounds that target GAPDH. The invention also provides kits useful in the practice of the inventive method. Compounds identified by inventive methods are also included in the invention.

US Patent:

7244498, Jul 17, 2007

Filed:

May 3, 2005

Appl. No.:

11/120650

Inventors:

Ronald Lee Cook - Lakewood CO, US
Silvia DeVito Luebben - Golden CO, US
Andrew William Myers - Arvada CO, US
Bryan Matthew Smith - Boulder CO, US
Brian John Elliott - Superior CO, US
Cory Kreutzer - Brighton CO, US
Carolina Wilson - Arvada CO, US
Manfred Meiser - Aurora CO, US

Assignee:

TDA Research, Inc. - Wheat Ridge CO

International Classification:

B32B 5/66

US Classification:

428402, 428403, 428404, 428405, 428407, 427214, 427215, 427220, 556179

Abstract:

Surface-modified nanoparticles of boehmite, and methods for preparing the same. Aluminum oxyhydroxide nanoparticles are surface modified by reaction with selected amounts of organic acids. In particular, the nanoparticle surface is modified by reactions with two or more different carboxylic acids, at least one of which is an organic carboxylic acid. The product is a surface modified boehmite nanoparticle that has an inorganic aluminum oxyhydroxide core, or part aluminum oxyhydroxide core and a surface-bonded organic shell. Organic carboxylic acids of this invention contain at least one carboxylic acid group and one carbon-hydrogen bond. One embodiment of this invention provides boehmite nanoparticles that have been surface modified with two or more acids one of which additional carries at least one reactive functional group. Another embodiment of this invention provides boehmite nanoparticles that have been surface modified with multiple acids one of which has molecular weight or average molecular weight greater than or equal to 500 Daltons. Yet, another embodiment of this invention provides boehmite nanoparticles that are surface modified with two or more acids one of which is hydrophobic in nature and has solubility in water of less than 15 by weight.