Zuzana Dostalova from 126 Thorndike St APT 1, Cambridge, MA 02141, age 56

Us Patents

Beta-1,6-Glucan Cetuximab Antibody Conjugates
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US Patent:

20180154014, Jun 7, 2018
Filed:

Jun 1, 2016
Appl. No.:

15/578343
Inventors:

- Waltham MA, US
John James Kane - Cambridge MA, US
James Michael Siedlecki - Burlington MA, US
Zuzana Dostalova - Cambridge MA, US
Ifat Rubin-Bejerano - Newton MA, US
Hua Miao - Newton MA, US
International Classification:

A61K 47/68
C07K 16/28
C07K 16/30
A61P 35/00
Abstract:

The present invention encompasses embodiments in which cetuximab or a related cetuximab antibody is conjugated to β-1,6-glucan oligomers. Thus, the present invention includes, among other things, compositions including cetuximab conjugated to one or more β-1,6-glucan oligomers. The present invention further includes, among other things, methods of making and/or using such β-1,6-glucan conjugates. In certain embodiments, a β-1,6-glucan conjugate of the present invention is useful as a therapeutic or in a method of therapy.

Compositions And Methods For Cancer Immunotherapy
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US Patent:

20170369570, Dec 28, 2017
Filed:

Jan 20, 2016
Appl. No.:

15/543366
Inventors:

- Waltham MA, US
Gabriel Oscar Reznik - Bedford MA, US
Zuzana Dostalova - Cambridge MA, US
International Classification:

C07K 16/28
A61K 47/61
A61K 39/395
A61K 39/00
Abstract:

The present invention includes, among other things, β-1,6-glucan linked to an antibody directed to a cell present in a tumor microenvironment. T regulatory cells can be one type of cell present in the tumor microenvironment. In particular embodiments, the antibody is directed to a surface feature of a T regulatory cell, MDSC, or other immune cell. In certain embodiments, the antibody is directed to T regulatory cells, MDSCs, or other immune cells present in a tumor microenvironment. Compositions including β-1,6-glucan linked to an antibody directed to a T regulatory cell, MDSC, or other immune cell may be useful, e.g., in the treatment of a tumor or cancer in a subject in need thereof. Accordingly, the present invention provides, among other things, methods and compositions for treatment of a tumor or cancer.

Resumes

Scientist

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Location:

Cambridge, MA

Industry:

Hospital & Health Care

Work:

Eisai Research Institute
Scientist
Abpro
Scientist, Team Leader, Protein Purification
Harvard University Aug 2005 - Jun 2011
Postdoctoral Research Scientist
Millenium Research Laboratory 2010 - 2010
Bioanalytical Consultant
Uthscsa 1999 - 2004
Postdoctoral Fellow

Education:

Leibniz Universität Hannover 1993 - 1998
Doctorates, Doctor of Philosophy, Biochemistry Charles University
Master of Science, Masters, Bachelors, Bachelor of Science, Chemistry

Skills:

Membrane Protein Purification and Functional Reconstitution

Languages:

English
German
Czech
French
Russian

Zuzana Dostalova Cambridge, MA

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Work:

Eisai Pharmaceuticals

May 2013 to 2000
Research Scientist Abpro Corporation
Lexington, MA
2011 to 2013
Research Scientist MGH, Harvard Medical School
Boston, MA
2005 to 2011
Postdoctoral Fellow and Research Scientist

Education:

University Hannover
1993 to 1998
Ph.D. in sperm-egg recognition and a role of carbohydrates Charles University
Praha
1993
M.Sc. in Biochemistry Charles University
Praha
1991
B.Sc. in Biochemistry

Skills:

Production of recombinant proteins

Zuzana Dostalova Cambridge, MA

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Work:

Abpro Corporation

2011 to 2000
Research Scientist Massachusetts General Hospital, Harvard Medical School
Boston, MA
2005 to 2011
Postdoctoral Scientist Millennium Research Laboratories
Boston, MA
2010 to 2010
Bioanalytical Consultant UTHSC
San Antonio, TX
1999 to 2004
Postdoctoral Fellow

Education:

University Hannover
Germany
1993 to 1998
Ph.D. in Biochemistry Thesis title: Purification and functional characterization of lectin-like proteins involved in sperm-egg recognition and a role of carbohydrates in cell-cell interaction Charles University
Praha
1993
M.Sc. in Biochemistry Charles University
Praha
1991
B.Sc. in Biochemistry

Skills:

Expertise in membrane protein expression, purification and functional reconstitution into lipids. Six years of experience with neurotransmitter-gated ion channels (GABAA and serotonin receptors) leading to identification of receptor drug binding sites. Two years of industrial experience as a team leader of protein purification unit at Abpro; utilizing high throughput screening and scale-up production, purified hundreds of recombinant proteins, secreted, cytoplasmic, and membrane proteins for antibody production and sale. Technical expertise in protein expression in a variety of hosts, primarily insect cells and mammalian cell lines on plates and scale up to 10L using a Bioreactor. More than ten years of experience with classical chromatographic methods and protein chemistry techniques: FPLC and HPLC (AKTA purifier), SDS-PAGE, Western Blotting, and Capillary electrophoresis (Calliper). As a bioanalytical consultant for Millenium Research Laboratories developed and validated enzyme linked immunosorbent assay (ELISA). Design, analyze, and conduct experiments independently. Critical thinker, strong team player focusing on teams mutual success.