Utmb Jun 1992 - Apr 1994
Postdoctoral Fellow
Stehlin Foundation For Cancer Research Jun 1992 - Apr 1994
Chief Chemist
Education:
University of Delaware 1988 - 1992
Doctorates, Doctor of Philosophy, Philosophy, Organic Chemistry
Central China Normal University 1984 - 1987
Masters, Organic Chemistry
Skills:
Science Chemistry Spectroscopy Analytical Chemistry Characterization Materials Science Hplc Mass Spectrometry Research Statistics Lifesciences Laboratory Organic Chemistry R&D Nanotechnology
Languages:
English Mandarin
Us Patents
Liposomal Prodrugs Comprising Derivatives Of Camptothecin And Methods Of Treating Cancer Using These Prodrugs
Zhisong Cao - Friendswood TX Beppino C. Giovanella - Houston TX
Assignee:
The Stehlin Foundation For Cancer Research - Houston TX
International Classification:
A61K 3144
US Classification:
514283, 546 48
Abstract:
Derivatives of camptothecin as represented by the general formula: are described, wherein when R is H, R. is a C -C alkyl group, a C -C alkyl group, a C -C cycloalkyl group, a C -C alkenyl group or a C -C epoxy group; and when R is a nitro group or an amino group, R is a C -C alkyl group, a C -C alkenyl group, a C -C cycloalkyl group, or an epoxy group. Liposomal prodrugs including these specific derivatives of camptothecin restrained by a liposomal delivery system are also described. Processes for making these prodrugs and for using them in cancer treatment are also disclosed.
Derivatives Of Camptothecin And Methods Of Treating Cancer Using These Derivatives
Zhisong Cao - Friendswood TX Beppino C. Giovanella - Houston TX
Assignee:
The Stehlin Foundation For Cancer Research - Houston TX
International Classification:
A61K 314375
US Classification:
514283, 546 48
Abstract:
Derivatives of camptothecin are disclosed and are represented by the general formula: wherein when R is H, R is a C -C alkyl group, a C -C alkyl group, a C -C cycloalkyl group, a C -C alkenyl group or a C -C epoxy group; and when R is a nitro group, R is a C -C alkyl group, a C -C alkenyl group, a C -C cycloalkyl group, or an expoxy group. Processes for making these derivatives and for using them in cancer treatment are also disclosed.
Aromatic Esters Of Camptothecins And Methods To Treat Cancers
Zhisong Cao - Friendswood TX Beppino C. Giovanella - Houston TX
Assignee:
The Stehlin Foundation For Cancer Research - Houston TX
International Classification:
C07D47112
US Classification:
546 48, 546 51
Abstract:
Aromatic camptothecin ester compounds having the formula: are described as well as formulations containing the compounds. Methods of treating cancer and/or tumors are also disclosed.
Cascade Esters Of Camptothecins And Methods Of Treating Cancer Using These Compounds
The Christus Stehlin Foundation for Cancer Research - Houston TX
International Classification:
A61K 31/4745 C07D 491/22
US Classification:
514283, 546 48
Abstract:
Hydrated crystalline camptothecin esters, such as crystalline aliphatic ester hydrates of camptothecin, pharmaceutical compositions containing crystalline aliphatic ester hydrates of camptothecin, methods of treating a cancer or malignant tumor using the crystalline camptothecin ester hydrates and methods of making the same are described.
The Christus Stehlin Foundation for Cancer Research - Houston TX
International Classification:
C07D 491/22
US Classification:
546 48, 546 47
Abstract:
Methods of preparing CPT-esters are described. The methods include using at least one acid in the esterification reactions or acylation reactions of camptothecins.
Derivatives Of Camptothecin And Methods Of Treating Cancer Using These Derivatives
Zhisong Cao - Friendswood TX, US Beppino Giovanella - Houston TX, US
International Classification:
A61K031/4745 C07D498/14
US Classification:
514/283000, 546/048000
Abstract:
Derivatives of camptothecin are disclosed and are represented by the general formula: wherein when Ris H, Ris a C-Calkyl group, a C-Calkyl group, a C-Ccycloalkyl group, a C-Calkenyl group or a C-Cepoxy group; and when Ris a nitro group, Ris a C-Calkyl group, a C-Calkenyl group, a C-Ccycloalkyl group, or an epoxy group. Processes for making these derivatives and for using them in cancer treatment are also disclosed.
Name / Title
Company / Classification
Phones & Addresses
Zhisong Cao Director
TOPO MEDTECH INC Mfg Medicinal/Botanical Products Business Services at Non-Commercial Site
843 Saint Elmos Ct, Missouri City, TX 77459
Youtube
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