Zhiping Wu

Author:

Zhiping Wu

ISBN #:

7501172285

US Patent:

20110201947, Aug 18, 2011

Filed:

Mar 16, 2009

Appl. No.:

12/922473

Inventors:

Stanley L. Hazen - Pepper Pike OH, US
Stephen James Nicholls - Cleveland Heights OH, US
Zhiping Wu - Cleveland OH, US

Assignee:

THE CLEVELAND CLINIC FOUNDATION - Cleveland OH

International Classification:

A61B 5/0205
C12Q 1/44
C07K 16/40
G01N 33/573

US Classification:

600485, 435 19, 5303871, 435 71

Abstract:

The present invention provides methods and markers for characterizing a subject's, particularly a human subject risk of having cardiovascular disease. The present invention also provides methods of characterizing a subject's risk of developing cardiovascular disease. In another embodiment, the present invention provides methods for characterizing a subject's risk of experiencing a complication of cardiovascular disease or major adverse cardiac event within 1, 3, or 10 years. In another embodiment, the present invention provides a method for determining whether a subject presenting with chest pain is at risk near term of experiencing a heart attack or other major adverse cardiac event. The present methods are especially useful for identifying those subjects who are in need of highly aggressive CVD therapies as well as those subjects who require no therapies targeted at inhibiting or preventing CVD or complications of CVD.