Zhi M Cai

US Patent:

20120082985, Apr 5, 2012

Filed:

Aug 11, 2008

Appl. No.:

12/672889

Inventors:

Frederic Zenhausern - Fountain Hills AZ, US
Ralf Lenigk - Chandler AZ, US
Jianing Yang - Tampe AZ, US
Zhi Cai - Chandler AZ, US
Alan Nordquist - Payson AZ, US
Stanley D. Smith - Phoenix AZ, US
David Maggiano - Phoenix AZ, US
Mrinalini Prasad - Chandler AZ, US
Karem Linan - Queen Creek AZ, US
Edward Olaya - Phoenix AZ, US
Baiju Thomas - Chandler AZ, US
Cedric Hurth - Tempe AZ, US
Darryl Cox - Lavven AZ, US
Mark Richard - Maricopa AZ, US
Glen Mccarty - Tempe AZ, US

International Classification:

C12Q 1/68
G01N 33/53
G01N 27/447
C12M 1/34
C12M 1/40

US Classification:

435 612, 435 61, 4352872, 204452, 204603

Abstract:

A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the sample, amplifying the DNA, separating fragments of the amplified DNA, detecting the separated fragments using laser induced fluorescence, based on the detecting, generating a profile of the DNA in the received sample, comparing the generated profile with profiles of DNA stored in a database, and upon determining that the generated profile matches one of the stored profiles, identifying the source from which the stored profile was obtained, wherein the receiving, lysing, purifying, amplifying, and detecting are performed on corresponding portions of a microfluidic device, and wherein transporting the sample and the DNA to the portions of the microfluidic device and enabling the lysing, purifying, amplifying, separating, detecting, generating, comparing, and identifying are performed automatically without user interaction.

US Patent:

20100267092, Oct 21, 2010

Filed:

Feb 9, 2010

Appl. No.:

12/703037

Inventors:

Frederic ZENHAUSERN - Fountain Hills AZ, US
Alan Nordquist - Payson AZ, US
Ralf Lenigk - Chandler AZ, US
Cedric Hurth - Tempe AZ, US
Jianing Yang - Tempe AZ, US
Xiaojia Chen - Chandler AZ, US
Matthew Estes - Tempe AZ, US
John Lee-Edghill - Birmingham, GB
Nina Moran - Birmingham, GB
Andrew Hopwood - Birmingham, GB
Pieris Koumi - Birmingham, GB
Zhi Cai - Chandler AZ, US

International Classification:

C12P 19/34
C12M 1/36
C12M 1/00
G01N 33/48
B65G 53/66

US Classification:

435 912, 4352865, 4352831, 436 63, 436 94, 406 29

Abstract:

A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.

US Patent:

20170087553, Mar 30, 2017

Filed:

Sep 2, 2016

Appl. No.:

15/255406

Inventors:

- Fountain Hills AZ, US
Alan NORDQUIST - Payson AZ, US
Ralf LENIGK - Chandler AZ, US
Cedric HURTH - Tempe AZ, US
Jianing YANG - Tempe AZ, US
Xiaojia CHEN - Chandler AZ, US
Matthew ESTES - Tempe AZ, US
John LEE-EDGHILL - Birmingham, GB
Nina MORAN - Birmingham, GB
Andrew HOPWOOD - Birmingham, GB
Pieris KOUMI - Birmingham, GB
Zhi CAI - Chandler AZ, US

International Classification:

B01L 3/00
G01N 21/64
B01L 7/00
G01N 27/447
C12Q 1/68
G01N 1/10

Abstract:

A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.

US Patent:

20140186841, Jul 3, 2014

Filed:

Sep 23, 2013

Appl. No.:

14/034153

Inventors:

Frederic ZENHAUSERN - Fountain Hills AZ, US
Ralf LENIGK - Chandler, AZ
Jianing YANG - Tempe AZ, US
Zhi CAI - Chandler AZ, US
Alan NORDQUIST - Payson AZ, US
Stanley D. SMITH - Phoenix AZ, US
David MAGGIANO - Phoenix AZ, US
Glen MCCARTY - Tempe AZ, US
Mrinalini PRASAD - Chandler AZ, US
Karem LINAN - Queen Creek AZ, US
Baiju THOMAS - Chandler AZ, US
Edward OLAYA - Phoenix AZ, US
Cedric HURTH - Tempe AZ, US
Darryl COX - Laveen AZ, US
Mark RICHARD - Maricopa AZ, US

International Classification:

C12Q 1/68

US Classification:

435 612, 4352872

Abstract:

A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the sample, amplifying the DNA, separating fragments of the amplified DNA, detecting the separated fragments using laser induced fluorescence, based on the detecting, generating a profile of the DNA in the received sample, comparing the generated profile with profiles of DNA stored in a database, and upon determining that the generated profile matches one of the stored profiles, identifying the source from which the stored profile was obtained, wherein the receiving, lysing, purifying, amplifying, and detecting are performed on corresponding portions of a microfluidic device, and wherein transporting the sample and the DNA to the portions of the microfluidic device and enabling the lysing, purifying, amplifying, separating, detecting, generating, comparing, and identifying are performed automatically without user interaction.

US Patent:

20140178938, Jun 26, 2014

Filed:

Jul 8, 2013

Appl. No.:

13/936685

Inventors:

- Birmingham, GB
- Scottsdale AZ, US
Ralf LENIGK - Chandler AZ, US
Cedric HURTH - Tempe AZ, US
Jianing YANG - Tempe AZ, US
Xiaojia CHEN - Chandler AZ, US
Matthew ESTES - Tempe AZ, US
John LEE-EDGHILL - Birmingham, GB
Nina MORAN - Birmingham, GB
Andrew HOPWOOD - Birmingham, GB
Pieris KOUMI - Birmingham, GB
Zhi CAI - Chandler AZ, US

International Classification:

C12Q 1/68

US Classification:

435 912, 4352891

Abstract:

A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.