Yufeng Wang

US Patent:

7652023, Jan 26, 2010

Filed:

Nov 16, 2006

Appl. No.:

11/560388

Inventors:

Yufeng Wang - North Brunswick NJ, US
Wu Yang - Princeton Junction NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/506
A61K 31/4745
A61K 31/4439
C07D 403/02

US Classification:

514275, 514337, 514338, 514340, 514370, 514336, 544331, 5462684, 5462727, 5462681, 5462697, 548190, 548202

Abstract:

Compounds of formula Ia and Ib.

US Patent:

7790745, Sep 7, 2010

Filed:

Oct 18, 2006

Appl. No.:

11/582784

Inventors:

Wu Yang - Princeton Junction NJ, US
Yufeng Wang - North Brunswick NJ, US
Ellen K. Kick - Ewing NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 403/02
A61K 31/4709

US Classification:

514310, 546146

Abstract:

A compound of formula I.

US Patent:

7790770, Sep 7, 2010

Filed:

Nov 13, 2006

Appl. No.:

11/558979

Inventors:

Mark E. Salvati - Pennington NJ, US
Heather Finlay - Skillman NJ, US
Lalgudi S. Harikrishnan - Princeton NJ, US
Ji Jiang - West Windsor NJ, US
James A. Johnson - Pennington NJ, US
Muthoni G. Kamau - Lawrenceville NJ, US
R. Michael Lawrence - Yardley PA, US
John Lloyd - Yardley PA, US
Michael M. Miller - Pennington NJ, US
Zulan Pi - Pennington NJ, US
Jennifer X. Qiao - Princeton NJ, US
Richard A. Rampulla - Flemington NJ, US
Jacques Y. Roberge - Princeton NJ, US
Tammy C. Wang - Lawrenceville NJ, US
Yufeng Wang - North Brunswick NJ, US
Wu Yang - Princeton Junction NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/164
C07C 233/64

US Classification:

514617, 514622, 514364, 5142312, 514408, 514452, 514381, 562450, 564161, 544106, 548250, 548400, 549200

Abstract:

Compounds of formula Ia and Ib.

US Patent:

7888376, Feb 15, 2011

Filed:

Nov 15, 2006

Appl. No.:

11/559930

Inventors:

Mark E. Salvati - Lawrenceville NJ, US
Heather Finlay - Skillman NJ, US
Lalgudi S. Harikrishnan - Princeton NJ, US
Ji Jiang - West Windsor NJ, US
James A. Johnson - Pennington NJ, US
Muthoni G. Kamau - Lawrenceville NJ, US
R. Michael Lawrence - Yardley PA, US
Michael M. Miller - Pennington NJ, US
Jennifer X. Qiao - Princeton NJ, US
Tammy C. Wang - Lawrenceville NJ, US
Yufeng Wang - North Brunswick NJ, US
Wu Yang - Princeton Junction NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 213/56
A61K 31/44

US Classification:

514357, 546336

Abstract:

Compounds of formula Ia and Ib.

US Patent:

8304403, Nov 6, 2012

Filed:

Jun 10, 2010

Appl. No.:

12/797760

Inventors:

Mark E. Salvati - Lawrenceville NJ, US
Heather Finlay - Skillman NJ, US
Lalgudi S. Harikrishnan - Princeton NJ, US
Ji Jiang - West Windsor NJ, US
James A. Johnson - Pennington NJ, US
Muthoni G. Kamau - Lawrenceville NJ, US
R. Michael Lawrence - Yardley PA, US
Jianqing Li - Guilford CT, US
John Lloyd - Yardley PA, US
Michael M. Miller - Pennington NJ, US
Zulan Pi - Pennington NJ, US
Jennifer X. Qiao - Princeton NJ, US
Richard A. Rampulla - Flemington NJ, US
Jacques Y. Roberge - Princeton NJ, US
Tammy C. Wang - Lawrenceville NJ, US
Yufeng Wang - North Brunswick NJ, US
Wu Yang - Princeton Junction NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/695
A61K 31/17
A61K 31/165
A61K 31/426
A61K 31/4468
A61K 31/50
A61K 31/535
C07C 273/00
C07D 277/20
C07D 211/98
C07D 239/02
C07D 205/08

US Classification:

514 63, 514595, 514617, 514371, 514329, 514256, 5142312, 544335, 544106, 540200, 546244, 548196, 564 47, 564161

Abstract:

Compounds of formula Ia and Ib.

US Patent:

8642576, Feb 4, 2014

Filed:

Aug 29, 2012

Appl. No.:

13/597364

Inventors:

Mark E. Salvati - Lawrenceville NJ, US
Heather Finlay - Skillman NJ, US
Lalgudi S. Harikrishnan - Princeton NJ, US
Ji Jiang - West Windsor NJ, US
James A. Johnson - Pennington NJ, US
Muthoni G. Kamau - Lawrenceville NJ, US
R. Michael Lawrence - Yardley PA, US
Jianqing Li - Guilford CT, US
John Lloyd - Yardley PA, US
Michael M. Miller - Pennington NJ, US
Zulan Pi - Pennington NJ, US
Jennifer X. Qiao - Princeton NJ, US
Richard A. Rampulla - Flemington NJ, US
Jacques Y. Roberge - Princeton NJ, US
Tammy C. Wang - Lawrenceville NJ, US
Yufeng Wang - North Brunswick NJ, US
Wu Yang - Princeton Junction NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/166
A61K 31/137
A61K 31/426
A61K 31/4468
A61K 31/505
A61K 31/695
A61K 31/5375
A61K 31/17
C07C 275/26
C07C 233/73
C07C 37/02
C07C 41/01

US Classification:

514 63, 514595, 514617, 514648, 514371, 514329, 514256, 5142395, 514423, 564 56, 564185, 568775, 568656, 548196, 548538, 546224, 544335, 544165

Abstract:

Compounds of formula Ia and Ib.

US Patent:

20040229860, Nov 18, 2004

Filed:

Jan 27, 2004

Appl. No.:

10/766086

Inventors:

Ashvinikumar Gavai - Princeton Junction NJ, US
Roy Vaz - Branchburg NJ, US
John Dickson - Apex NC, US
Jacques Roberge - Princeton NJ, US
Wu Yang - Princeton NJ, US
Timur Gungor - Pennington NJ, US
James Corte - Lawrenceville NJ, US
David Rotella - Newtown PA, US
Yufeng Wang - North Brunswick NJ, US

International Classification:

C 07D 4 3/02
A61K031/517

US Classification:

514/210210, 514/310000, 514/266200, 544/284000, 546/148000, 548/465000

Abstract:

The present invention relates to modulators of the calcium sensing receptor having the formula I wherein Ar, X, n, R, R, Rand Q are as defined herein.

US Patent:

20120041190, Feb 16, 2012

Filed:

Feb 10, 2011

Appl. No.:

13/024544

Inventors:

James R. Corte - Lawrenceville NJ, US
Tianan Fang - Levittown PA, US
Carl P. Decicco - New Hope PA, US
Donald J.P. Pinto - Churchville PA, US
Karen A. Rossi - Newtown PA, US
Zilun Hu - Jamison PA, US
Yoon Jeon - Belle Mead NJ, US
Mimi L. Quan - Yardley PA, US
Joanne M. Smallheer - Yardley PA, US
Yufeng Wang - North Brunswick NJ, US
Wu Yang - Princeton Junction NJ, US

International Classification:

C07D 487/06
C07D 513/06
C07D 498/16

US Classification:

540456, 540468, 540477, 540472, 540469, 540460, 540461

Abstract:

The present invention provides compounds of Formula (I):or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.