Yueheng P Jiang from Belmont, MA, age 53

Us Patents

2,3-Substituted Indole Derivatives For Treating Viral Infections
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US Patent:

8143305, Mar 27, 2012
Filed:

Aug 27, 2008
Appl. No.:

12/675897
Inventors:

Gopinadhan N. Anilkumar - Edison NJ, US
Frank Bennett - Cranford NJ, US
Tin-Yau Chan - Edison NJ, US
Kevin X. Chen - Edison NJ, US
Mousumi Sannigrahi - Summit NJ, US
Francisco Velazquez - Clinton NJ, US
Srikanth Venkatraman - Edison NJ, US
Qingbei Zeng - Edison NJ, US
Jose S. Duca - Cranford NJ, US
Charles A. Lesburg - Short Hills NJ, US
Joseph A. Kozlowski - Princeton NJ, US
F. George Njoroge - Warren NJ, US
Stuart B. Rosenblum - West Orange NJ, US
Neng-Yang Shih - Lexington MA, US
Stephen J. Gavalas - Manhasset NY, US
Yueheng Jiang - Whitehouse Station NJ, US
Patrick A. Pinto - Morris Plains NJ, US
Haiyan Pu - Livingston NJ, US
Oleg B. Selyutin - West Windsor NJ, US
Bancha Vibulbhan - Kenilworth NJ, US
Li Wang - Nanuet NY, US
Wanli Wu - New Haven CT, US
Weiying Yang - Monmouth Junction NJ, US
Yuhua Huang - Westfield NJ, US
Hsueh-Cheng Huang - Scarsdale NY, US
Robert Palermo - Seattle WA, US
Boris Feld - New Milford NJ, US
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

A01N 43/38
A61K 31/40
C07D 209/04
US Classification:

514412, 548469, 546122, 546152, 546255
Abstract:

The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

4, 5-Ring Annulated Indole Derivatives For Treating Or Preventing Of Hcv And Related Viral Infections
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US Patent:

8546420, Oct 1, 2013
Filed:

Dec 17, 2007
Appl. No.:

12/519728
Inventors:

Gopinadhan N. Anilkumar - Edison NJ, US
Yueheng Jiang - Whitehouse Station NJ, US
Stuart B. Rosenblum - West Orange NJ, US
Srikanth Venkatraman - Edison NJ, US
Francisco Velazquez - Clinton NJ, US
Neng-Yang Shih - Lexington MA, US
F. George Njoroge - Warren NJ, US
Joseph A. Kozlowski - Princeton NJ, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

A01N 43/42
A61K 31/44
C07D 471/00
C07D 491/00
US Classification:

514292, 546 85, 548430
Abstract:

The present invention relates to 4,5-ring annulated indole derivatives of formula (I), compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient,.

Pyrazinyl Substituted Piperazine-Piperidines With Cxcr3 Antagonist Activity
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US Patent:

20070054919, Mar 8, 2007
Filed:

Feb 14, 2006
Appl. No.:

11/354138
Inventors:

Stuart Rosenblum - West Orange NJ, US
Seong Kim - Livingston NJ, US
Qingbei Zeng - Edison NJ, US
Michael Wong - North Brunswick NJ, US
Gopinadhan Anilkumar - Edison NJ, US
Yueheng Jiang - Whitehouse Station NJ, US
Wensheng Yu - Edison NJ, US
Joseph Kozlowski - Princeton NJ, US
Neng-Yang Shih - Warren NJ, US
Bandarpalle Shankar - Branchburg NJ, US
Brian McGuinness - Plainsboro NJ, US
Guizhen Dong - Dayton NJ, US
Lisa Zawacki - Yardley PA, US
Douglas Hobbs - Yardley PA, US
John Baldwin - Gwynedd Valley PA, US
Yuefei Shao - , US
International Classification:

A61K 31/497
C07D 403/14
US Classification:

514252110, 544357000
Abstract:

The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: and the pharmaceutically acceptable salts, solvates and esters thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.

Tricyclic Indole Derivatives And Methods Of Use Thereof
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US Patent:

20110189127, Aug 4, 2011
Filed:

Jun 10, 2009
Appl. No.:

12/997654
Inventors:

Srikanth Venkatraman - Edison NJ, US
Anilkumar Gopinadhan Nair - Edison NJ, US
Kevin X. Chen - Edison NJ, US
Francisco Valazquez - Clinton NJ, US
Qingbei Zeng - Edison NJ, US
Duan Liu - Arlington MA, US
Yueheng Jiang - Whitehouse Station NJ, US
Joseph A. Kozlowski - Princeton NJ, US
F. George Njoroge - Warren NJ, US
Stuart B. Rosenblum - West Orange NJ, US
Stephen J. Gavalas - Manhasset NY, US
Patrick A. Pinto - Morris Plains NJ, US
Oleg B. Selyutin - West Windsor NJ, US
Bancha Vibulbhan - Kenilworth NJ, US
International Classification:

A61K 31/4439
C07D 401/14
C07D 491/22
A61K 31/437
A61K 31/517
A61K 31/47
A61K 38/21
A61K 31/7052
A61K 39/00
A61K 39/395
A61K 31/7056
A61P 31/12
US Classification:

424 854, 5462767, 514338, 546 48, 514280, 544284, 51426621, 546174, 514314, 514 44 A, 4241841, 4241301, 4241411, 514 43
Abstract:

The present invention relates to Tricyclic Indole Derivatives, compositions comprising at least one Tricyclic Indole Derivatives, and methods of using the Tricyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

Novel Salt Forms Of Urat-1 Inhibitors
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US Patent:

20220371996, Nov 24, 2022
Filed:

May 19, 2022
Appl. No.:

17/748134
Inventors:

- Shanghai, CN
Yueheng JIANG - Belmont MA, US
International Classification:

C07D 213/70
A61K 31/426
A61K 31/522
A61K 31/4418
Abstract:

Provided herein are compounds, salts, crystalline forms, and pharmaceutical compositions that are related to thiobutyrate compounds, such as Compound (1) and its salts (such as sodium, potassium, and calcium salt), as well as methods of preparing the same. Also provided herein are methods of using the compounds, salts, crystalline forms, and pharmaceutical compositions for the treatment of diseases or disorders, such as gout and hyperuricemia.

Novel Salts Of Selective Estrogen Receptor Degraders
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US Patent:

20220202790, Jun 30, 2022
Filed:

Jan 4, 2022
Appl. No.:

17/568324
Inventors:

- Shanghai, CN
Yueheng JIANG - Belmont MA, US
International Classification:

A61K 31/4375
A61K 45/06
C07D 471/04
Abstract:

Provided herein are compounds, salts, crystalline forms, and pharmaceutical compositions that are related to Selective Estrogen Receptor Degraders, as well as methods of preparing the same. Also provided herein are methods of using the compounds, salts, crystalline forms, and pharmaceutical compositions for the treatment of diseases or disorders, such as breast cancer.

Novel Salt Forms Of Urat-1 Inhibitors
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US Patent:

20210032204, Feb 4, 2021
Filed:

Mar 26, 2019
Appl. No.:

17/041855
Inventors:

- Shanghai, CN
Yueheng JIANG - Belmont MA, US
International Classification:

C07D 213/70
A61K 9/20
A61K 9/48
Abstract:

Provided herein are compounds, salts, crystalline forms, and pharmaceutical compositions that are related to thiobutyrate compounds, such as Compound (1) and its salts (such as sodium, potassium, and calcium salt), as well as methods of preparing the same. Also provided herein are methods of using the compounds, salts, crystalline forms, and pharmaceutical compositions for the treatment of diseases or disorders, such as gout and hyperuricemia.

Heterocyclic Compounds, Preparation Methods Therefor, And Methods Of Uses Thereof
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US Patent:

20210017187, Jan 21, 2021
Filed:

Jun 24, 2020
Appl. No.:

16/910878
Inventors:

- Shanghai, CN
Yaolin WANG - Short Hills NJ, US
Yueheng JIANG - Belmont MA, US
Yanqin LIU - Shanghai, CN
Haotao NIU - Shanghai, CN
Zhenwu WANG - Shanghai, CN
Zixing HAN - Shanghai, CN
Liangshan TAO - Shanghai, CN
Jifang WENG - Shanghai, CN
Zhe SHI - Shanghai, CN
International Classification:

C07D 493/08
C07D 401/14
C07D 405/14
C07D 487/04
C07D 417/14
Abstract:

Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.