Christopher Cardozo - New York City NY, US William A. Bauman - New Rochelle NY, US Weidong Zhao - Riverdale NY, US Yong Wu - Edison NJ, US
Assignee:
United States of America as represented by the Department of Veterans Affairs - Washington DC
International Classification:
C12N 15/00 C12N 15/63 C07H 21/04 C12Q 1/68
US Classification:
4353201, 435455, 536 241
Abstract:
The disclosure provides nucleic acids including the polynucleotide sequence of the human MAFbx core promoter involved in muscle specific expression. Also provided are reporters operably linked to a polynucleotide sequence including MAFbx transcription regulatory sequences, and constructs including polynucleotides that encode reporters and other polynucleotide sequences operably linked to the MAFbx core transcription regulatory sequence. Systems for identifying agents that inhibit muscle loss and/or increase muscle mass or tone are also provided.
Screening Tools For Discovery Of Novel Anabolic Agents
Christopher Cardozo - New York City NY, US William A. Bauman - New Rochelle NY, US Weidong Zhao - Riverdale NY, US Yong Wu - Edison NJ, US
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
The disclosure provides nucleic acids including the polynucleotide sequence of the human MAFbx core promoter involved in muscle specific expression. Also provided are reporters operably linked to a polynucleotide sequence including MAFbx transcription regulatory sequences, and constructs including polynucleotides that encode reporters and other polynucleotide sequences operably linked to the MAFbx core transcription regulatory sequence. Systems for identifying agents that inhibit muscle loss and/or increase muscle mass or tone are also provided.
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Yong Wu
Education:
Zhejiang University - Software Engineer, Hunan University - Computer Science