Michael Wittekind - Doylestown PA Steven Weinheimer - Northford CT Yaqun Zhang - Holland PA Valentina Goldfarb - Franklin Park NJ
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12N 950 C12N 900 C12N 500 C07H 2102
US Classification:
435219
Abstract:
The present invention relates to modified Hepatitis C NS3 proteases and modified Hepatitis C NS4a-NS3 fusion proteases. These proteins are highly soluble and are useful for NMR spectroscopy, X-ray crystallography, and inhibitor screening. DNA constructs are also provided.
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