Ya-Huei H Kuo

US Patent:

20210115443, Apr 22, 2021

Filed:

Sep 2, 2020

Appl. No.:

17/010259

Inventors:

- Duarte CA, US
Piotr Marek Swiderski - San Dimas CA, US
Guido Marcucci - Azusa CA, US
Bin Zhang - Duarte CA, US
Ya-Huei Kuo - Duarte CA, US

International Classification:

C12N 15/113
A61K 31/7004
A61K 47/54
A61K 31/704
A61K 45/06
C12N 15/11
A61K 31/7125
A61P 35/02
A61K 31/506

Abstract:

The present disclosure relates to a compound including a nucleic acid sequence conjugated to an anti-microRNA or a microRNA-mimic or a compound including a modified anti-microRNA sequence, compositions of such a compound, and method of treatment of a disease, and method of suppressing microRNA activity by the disclosed compound or composition.

US Patent:

20200281982, Sep 10, 2020

Filed:

Mar 5, 2020

Appl. No.:

16/810739

Inventors:

- Duarte CA, US
Bin Zhang - Duarte CA, US
Ya-Huei Kuo - Duarte CA, US
Marcin Tomasz Kortylewski - Monrovia CA, US

International Classification:

A61K 35/28
C12N 15/113
A61K 45/06
A61P 35/00

Abstract:

Provided herein are, inter alia, methods of treating red blood cell disorders and cancer using anti-miR126 compounds. The methods include administering phosphorothioated CpG oligodeoxynucleotides conjugated to an anti-miR126 nucleic acid sequence to treat red blood cell disorders. Other methods provided herein include administering phosphorothioated CpG oligodeoxynucleotides conjugated to an anti-miR126 nucleic acid sequence and a tyrosine kinase inhibitor to treat cancer.

US Patent:

20180312837, Nov 1, 2018

Filed:

Oct 14, 2016

Appl. No.:

15/768405

Inventors:

- Duarte CA, US
Piotr Marek Swiderski - San Dimas CA, US
Guido Marcucci - Azusa CA, US
Bin Zhang - Duarte CA, US
Ya-Huei Kuo - Duarte CA, US

International Classification:

C12N 15/113
A61K 31/7125
A61K 31/506
A61P 35/02

Abstract:

The present disclosure relates to a compound including a nucleic acid sequence conjugated to an anti-microRNA or a microRNA-mimic or a compound including a modified anti-microRNA sequence, compositions of such a compound, and method of treatment of a disease, and method of suppressing microRNA activity by the disclosed compound or composition.