Xingming M Shi

US Patent:

6967078, Nov 22, 2005

Filed:

Aug 3, 2000

Appl. No.:

09/631411

Inventors:

Xu Cao - Birmingham AL, US
Xingming Shi - Birmingham AL, US
Shuting Bai - Birmingham AL, US

International Classification:

C12Q001/68
C07H021/04
C12N015/00

US Classification:

435 6, 435 691, 435 911, 536 231, 536 235

Abstract:

The present invention describes a novel interaction between Smad6 and the Hox genes in nuclear transcriptional regulation following BMP signal transduction. The present invention further provides methods of using this novel Smad6/Hox protein interaction to regulate gene expression, regulate bone formation and control osteoporosis. Further provided are methods of screening for compounds that interfere with the novel Smad6/Hox protein interaction, thereby resulting in expression of a Hox protein-repressed gene and/or stimulating bone formation.

US Patent:

20020082235, Jun 27, 2002

Filed:

Aug 31, 2001

Appl. No.:

09/943724

Inventors:

Xu Cao - Birmingham AL, US
Xingming Shi - Birmingham AL, US
Xiangli Yang - Birmingham AL, US

Assignee:

UAB Research Foundation

International Classification:

A61K048/00
C12N005/08

US Classification:

514/044000, 435/366000

Abstract:

The present invention demonstrates that BMP-2/4 activates osteopontin gene transcription by removing Hoxc-8 binding through Smad1 interaction with the Hoxc-8 DNA binding domain. Since the DNA binding domain is conserved in all Hox and homeodomain-containing proteins, Smad1 likely interacts with all Hox or homeodomain-containing proteins. Furthermore, the present invention reveals the Smad1-mediated transcriptional mechanism in the BMP-2/4 signaling pathway and also provides information about the transcriptional roles of the Hox genes during embryonic development.

US Patent:

20060034843, Feb 16, 2006

Filed:

Sep 14, 2005

Appl. No.:

11/227664

Inventors:

Xu Cao - Birmingham AL, US
Xingming Shi - Birmingham AL, US
Shuting Bai - Birmingham AL, US

International Classification:

C12Q 1/68
A61K 39/395
A61K 48/00
A61K 38/17

US Classification:

424143100, 435006000, 514012000, 514044000

Abstract:

The present invention describes a novel interaction between Smad6 and the Hox genes in nuclear transcriptional regulation following BMP signal transduction. The present invention further provides methods of using this novel Smad6/Hox protein interaction to regulate gene expression, regulate bone formation and control osteoporosis. Further provided are methods of screening for compounds that interfere with the novel Smad6/Hox protein interaction, thereby resulting in expression of a Hox protein-repressed gene and/or stimulating bone formation.

US Patent:

62844644, Sep 4, 2001

Filed:

Apr 5, 1999

Appl. No.:

9/286682

Inventors:

Xu Cao - Birmingham AL
Xingming Shi - Birmingham AL
Xiangli Yang - Birmingham AL

Assignee:

UAB Research Foundation - Birmingham AL

International Classification:

C12Q 168
C12N 1563

US Classification:

435 6

Abstract:

The present invention demonstrates that BMP-2/4 activates osteopontin gene transcription by removing Hoxc-8 binding through Smad1 interaction with the Hoxc-8 DNA binding domain. Since the DNA binding domain is conserved in all Hox and homeodomain-containing proteins, Smad1 likely interacts with all Hox or homeodomain-containing proteins. Furthermore, the present invention reveals the Smad1-mediated transcriptional mechanism in the BMP-2/4 signaling pathway and also provides information about the transcriptional roles of the Hox genes during embryonic development.