Xiaoying Y Shen

US Patent:

20120128758, May 24, 2012

Filed:

Apr 5, 2010

Appl. No.:

13/262706

Inventors:

S. Munir Alam - Durham NC, US
Barton F. Haynes - Durham NC, US
Moses D. Sekaran - Durham NC, US
Georgia Tomaras - Durham NC, US
Xiaoying Shen - Durham NC, US

International Classification:

A61K 39/385
A61K 38/21
A61P 31/18
A61K 9/127

US Classification:

424450, 42419611, 424 857, 4241881

Abstract:

The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.

US Patent:

20200095646, Mar 26, 2020

Filed:

Jul 5, 2017

Appl. No.:

16/315688

Inventors:

- Durham NC, US
Kelly Seaton - Durham NC, US
Xiaoying Shen - Durham NC, US
Nicole Yates - Durham NC, US
Barton F. Haynes - Durham NC, US
Nathan Vandergrift - Durham NC, US
Wes Rountree - Durham NC, US
John Bainbridge - Durham NC, US

International Classification:

C12Q 1/70
C07K 14/16

Abstract:

The invention is directed to methods, reagents and kits for detecting incident HIV-1 infection.