Xiaolei L Song

US Patent:

20190060490, Feb 28, 2019

Filed:

Oct 27, 2016

Appl. No.:

15/771786

Inventors:

SRIDHAR NIMMAGADDA - BALTIMORE MD, US
NIKITA OSKOLKOV - REISTERSTOWN MD, US
MICHAEL MCMAHON - COLUMBIA MD, US
XIAOLEI SONG - BALTIMORE MD, US
MARTIN G. POMPER - BALTIMORE MD, US

International Classification:

A61K 49/12
A61K 49/16
A61K 51/06
A61K 51/04
A61K 49/10
C08G 73/02
C08G 83/00

Abstract:

PAMAM dendrimer based CEST imaging agents, pharmaceutical compositions comprising the same and methods of uses thereof are disclosed.

US Patent:

20160187445, Jun 30, 2016

Filed:

Dec 18, 2015

Appl. No.:

14/973897

Inventors:

- Baltimore MD, US
Xiaolei Song - Baltimore MD, US

International Classification:

G01R 33/56
A61B 5/00
G01R 33/561
A61B 5/055

Abstract:

The present invention provides a novel approach for CEST MR imaging, called Multi-echo Parametric VARiation Saturation (Me-PaVARS) CEST. This method places multiple image readouts in between a series of saturation pulses. The saturation pulse parameters are varied in a designated systematic pattern, which allows the generation of CEST contrast maps by encoding the patterns of signal loss into the images for better discrimination between various CEST imaging agents. The saturation parameter changes include, but are not limited to, saturation amplitude (B), saturation length (t), number of pulses, shape of saturation pulses, amplitude of saturation pulses, saturation offset frequency, or a combination of these variations.

US Patent:

20160106871, Apr 21, 2016

Filed:

Apr 28, 2014

Appl. No.:

14/787039

Inventors:

- Baltimore MD, US
- Bethesda MD, US
Nikita Oskolkov - Reisterstown MD, US
Joel Patrick Schneider - Frederick MD, US
Xiaolei Song - Lutherville MD, US

Assignee:

The Johns Hopkins University - Baltimore MD
Kennedy Krieger Institute, Inc. - Baltimore MD
National Institute of Health - Bethesda MD

International Classification:

A61K 49/18
A61K 49/14

Abstract:

The present invention provides novel hydrogels through peptides, which are designed to self-assemble and produce magnetic resonance (MR) contrast through chemical exchange saturation transfer (CEST). The location and integrity of these gels could consequently be tracked using MR imaging. The self-assembly of the peptides into hydrogels can be brought about by a change in pH, ionic strength, temperature, and concentration of ions.

US Patent:

20160082132, Mar 24, 2016

Filed:

May 16, 2014

Appl. No.:

14/891531

Inventors:

- Baltimore MD, US
XIAOLEI SONG - BALTIMORE MD, US
SANGEETA RAY - ELLICOTT CITY MD, US
MARTIN G. POMPER - BALTIMORE MD, US
MICHAEL T. MCMAHON - COLUMBIA MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - BALTIMORE MD

International Classification:

A61K 49/10
A61B 6/00
A61B 6/03
A61B 5/055
A61B 5/00

Abstract:

Compositions and methods for chemical exchange saturation transfer (CEST) based magnetic resonance imaging (MRI) or frequency labeled exchange (FLEX) imaging are disclosed. Beta-hydroxycarboxylate and beta-aminocarboxylate derivatives including salicylic acid, salicylates, salicylic acid prodrugs, N-alkyl/aryl/acyl/sulfonyl-anthranilic acid analogs, and any aromatic compound with OH/NH group ortho to the carboxylic acid group are disclosed. Such compounds can be used as general MRI organic contrast agents and produce significantly improved contrast in MR images detectable through CEST or FLEX.

US Patent:

20160075667, Mar 17, 2016

Filed:

May 1, 2014

Appl. No.:

14/890311

Inventors:

- Baltimore MD, US
Xiaolei Song - Baltimore MD, US
Sangeeta Ray - Ellicott City MD, US
Martin G. Pomper - Baltimore MD, US
Michael T. McMahon - Columbia MD, US

International Classification:

C07D 249/04
C07D 231/14
A61K 49/10
C07D 233/90

Abstract:

The invention features novel heterocyclic compounds that are useful as MRI contrast agents. Specifically, the invention relates to a novel class of MRI contrast agents that produce significantly improved contrast in MR images that is detectable through chemical exchange saturation transfer (CEST) or frequency labeled exchange (FLEX) imaging. The MRI contrast agents of the invention include those delineated in the formulae provided herein. The invention also relates to various methods in which the MRI contrast agents are employed. Kits and pharmaceutical compositions thereof are also provided.

US Patent:

20120271159, Oct 25, 2012

Filed:

Apr 20, 2012

Appl. No.:

13/452221

Inventors:

Xiaolei Song - Lutherville-Timonium MD, US
Jeff W.M. Bulte - Fulton MD, US
Assaf A. Gilad - Baltimore MD, US
Michael T. McMahon - Columbia MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61B 5/055

US Classification:

600420

Abstract:

An embodiment in accordance with the present invention provides a method for obtaining a magnetic resonance image (MRI) or spectrum. The method includes a step of performing a chemical exchange saturation transfer (CEST) or magnetization transfer (MT) magnetic labeling experiment of a subject using an MRI machine. When performing the CEST or MT magnetic labeling experiment aspects of a saturation pulse or a serial saturation pulse sequence, such as length (t), number (N), offset (Δω), modulation frequency (ω) and power (B) can be varied in specific-designed schemes. Data is generated from the CEST magnetic labeling experiment and is transmitted to a data processing unit. The data is processed to generate a visual representation of the data.