Xiao Shen

US Patent:

20090217402, Aug 27, 2009

Filed:

May 18, 2006

Appl. No.:

11/914881

Inventors:

Kenneth Bernstein - Atlanta GA, US
Xiao Shen - Los Angeles CA, US

Assignee:

Emory University - Atlanta GA

International Classification:

A01K 67/00
C12N 15/00
C12N 5/00
A61K 35/12
A61K 39/00
C12N 15/63

US Classification:

800 18, 435455, 435325, 424 9321, 4241841, 800 13, 4353201

Abstract:

Methods and compositions are provided for modulating the activity of macrophage and macrophage-like cells, particularly by modulating the peptidase activity of such cells. In certain aspects, methods are provided for enhancing or suppressing the immune function of a host by increasing or decreasing, respectively, expression of a target peptidase in host macrophage and macrophage-like cells. Such methods for enhancing or suppressing the immune function of a host by increasing or inhibiting (suppressing or silencing) expression of a target peptidase in host macrophage and macrophage-like cells find use in methods for treating and/or preventing a number of diseases and conditions, including cancer, viral and/or bacterial infection, Alzheimer's disease, tissue transplant rejection, autoimmune diseases, and chronic inflammatory diseases. The invention also provides compositions and research tools related to these methods, including vectors for increasing or inhibiting the expression of a peptidase in macrophage and macrophage-like cells, macrophage and macrophage-like cells transfected with these vectors, genetically modified mice that over-express a target peptidase or in which expression of a target peptidase has been disrupted, and selective modulators of peptidase activity in macrophages as well as methods for identifying and using such modulators.

US Patent:

20170104541, Apr 13, 2017

Filed:

Dec 22, 2016

Appl. No.:

15/389069

Inventors:

- Plano TX, US
Dawei Zheng - Irvine CA, US
Xiao Shen - San Bruno CA, US
Morgan Chen - San Jose CA, US
Hongbing Lei - San Jose CA, US

International Classification:

H04B 10/40
H04L 27/36
H04B 10/516

Abstract:

An optical transceiver comprising an optical signal input, a first modulation section coupled to the optical signal input, a second modulation segment coupled to the optical signal input and positioned in serial with the first modulation section, wherein the first modulation section comprises a first digital electrical signal input, a first digital driver coupled to the first digital electrical signal input, and a first modulator coupled to the first digital driver, and wherein the second modulation section comprises a second digital electrical signal input, a second digital driver coupled to the second digital electrical signal input, and a second modulator coupled to the second digital driver, and an optical signal output coupled to the first modulation section and the second modulation section.

US Patent:

20150132007, May 14, 2015

Filed:

Nov 8, 2013

Appl. No.:

14/075882

Inventors:

- Plano TX, US
Dawei Zheng - Irvine CA, US
Xiao Shen - San Bruno CA, US
Morgan Chen - San Jose CA, US
Hongbing Lei - San Jose CA, US

Assignee:

Futurewei Technologies, Inc. - Plano TX

International Classification:

H04B 10/54
H04B 10/2575
H04L 27/36
H04B 10/40

US Classification:

398135, 398186

Abstract:

An optical transceiver comprising an optical signal input, a first modulation section coupled to the optical signal input, a second modulation segment coupled to the optical signal input and positioned in serial with the first modulation section, wherein the first modulation section comprises a first digital electrical signal input, a first digital driver coupled to the first digital electrical signal input, and a first modulator coupled to the first digital driver, and wherein the second modulation section comprises a second digital electrical signal input, a second digital driver coupled to the second digital electrical signal input, and a second modulator coupled to the second digital driver, and an optical signal output coupled to the first modulation section and the second modulation section.