Xian Yang

US Patent:

20080255005, Oct 16, 2008

Filed:

Dec 13, 2007

Appl. No.:

11/956268

Inventors:

David G. Gorenstein - Houston TX, US
Xian Bin Yang - Webster TX, US
Bruce A. Luxon - Galveston TX, US
Norbert Herzog - Friendswood TX, US

Assignee:

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

C40B 60/10

US Classification:

506 38

Abstract:

The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA or even PNAs.

US Patent:

20090123922, May 14, 2009

Filed:

Dec 13, 2007

Appl. No.:

11/956271

Inventors:

David G. Gorenstein - Houston TX, US
Xian Bin Yang - Webster TX, US
Bruce A. Luxon - Galveston TX, US
Norbert Herzog - Friendswood TX, US

Assignee:

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

C12Q 1/68
C40B 20/08

US Classification:

435 6, 506 6

Abstract:

The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA or even PNAs.

US Patent:

20110224099, Sep 15, 2011

Filed:

Mar 11, 2011

Appl. No.:

13/046531

Inventors:

David G. Gorenstein - Houston TX, US
Bruce A. Luxon - Galveston TX, US
Norbert Herzog - Friendswood TX, US
Xian Bin Yang - Webster TX, US

Assignee:

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

C40B 40/06

US Classification:

506 16

Abstract:

The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA or even PNAs.

US Patent:

20030162190, Aug 28, 2003

Filed:

Aug 6, 2002

Appl. No.:

10/214417

Inventors:

David Gorenstein - Houston TX, US
Bruce Luxon - Galveston TX, US
Norbert Herzog - Friendswood TX, US
Xian Yang - Webster TX, US

International Classification:

C12Q001/68
C12M001/34

US Classification:

435/006000, 435/287200

Abstract:

An apparatus and method for monitoring biological interactions is disclosed. The apparatus includes a substrate, a modified nucleotide aptamer attached to the substrate, a target molecule or portion thereof, wherein the interaction between the modified nucleotide aptamer and the target molecule or portion thereof is detected.