William Frank Barclay

Author:

William A. Barclay

ISBN #:

0771981074

Author:

William A. Barclay

ISBN #:

0771982097

Author:

William R. Barclay

ISBN #:

3443510035

Author:

William Robert Barclay

ISBN #:

0870412434

Author:

William Barclay

ISBN #:

0002150581

Author:

William Barclay

ISBN #:

0006230105

Author:

William Barclay

ISBN #:

0060603933

Author:

William Barclay

ISBN #:

0060604123

US Patent:

6410281, Jun 25, 2002

Filed:

Dec 14, 1999

Appl. No.:

09/461663

Inventors:

William R. Barclay - Boulder CO

Assignee:

Omegatech, Inc. - Boulder CO

International Classification:

A01N 2500

US Classification:

435134, 106 1425, 424126, 424606, 435243, 4352541, 4352571, 4352831, 435946

Abstract:

A process is provided for growing the microflora Thraustochytrium, Schizochytrium, and mixtures thereof, which includes the growing of the microflora in fermentation medium containing non-chloride containing sodium salts, in particular sodium sulfate. In a preferred embodiment of the present invention, the process produces microflora having a cell aggregate size useful for the production of food products for use in aquaculture. Further disclosed is a food product which includes Thraustochytrium, Schizochytrium, and mixtures thereof, and a component selected from flaxseed, rapeseed, soybean and avocado meal. Such a food product includes a balance of long chain and short chain omega-3 highly unsaturated fatty acids. Corrosion in a fermentor is reduced by obtaining microorganisms such as those of the genus Thraustochytrium or Schizochytrium from a saline environment and growing the microorganisms in the fermentor in a culture medium containing sodium ions provided by a non-chloride sodium salt such that the chloride concentration in the medium is less than about 3 grams chloride per liter.

US Patent:

6451567, Sep 17, 2002

Filed:

Dec 14, 1999

Appl. No.:

09/461709

Inventors:

William R. Barclay - Boulder CO

Assignee:

Omegatech, Inc. - Boulder CO

International Classification:

C12N 100

US Classification:

435134, 435 42, 435135, 435171, 435243, 4352571, 435946

Abstract:

A process is provided for growing the microflora Thraustochytrium, Schizochytrium, and mixtures thereof, which includes the growing of the microflora in fermentation medium containing non-chloride containing sodium salts, in particular sodium sulfate. In a preferred embodiment of the present invention, the process produces microflora having a cell aggregate size useful for the production of food products for use in aquaculture. Further disclosed is a food product which includes Thraustochytrium, Schizochytrium, and mixtures thereof, and a component selected from flaxseed, rapeseed, soybean and avocado meal. Such a food product includes a balance of long chain and short chain omega-3 highly unsaturated fatty acids. Further, a process for producing lipids includes a fermentation by growing euryhaline microorganisms which are capable of producing 1. 08 grams per liter of the fermentation medium per day of long chain omega-3 fatty acids per 40 grams of sugar per liter of the fermentation medium at a sodium ion concentration of 60% seawater.

US Patent:

6566123, May 20, 2003

Filed:

Aug 15, 2000

Appl. No.:

09/639426

Inventors:

William R. Barclay - Boulder CO

Assignee:

Martek Biosciences Boulder Corporation - Boulder CO

International Classification:

A01N 6300

US Classification:

4352571, 424 931, 426 61, 426 72, 435243, 435946

Abstract:

A biomass containing the microflora of the order Thraustochytriales preferably, Thraustochytrium, Schizochytrium, and mixtures thereof, is prepared by growing the microflora in a fermentation medium containing less than about 3 grams of chloride per liter of the cultural medium and a non-chloride containing sodium salts, in particular sodium sulfate. In a preferred embodiment, the process produces microflora having a cell aggregate size less than about 150 microns useful for the production of food products for use in aquaculture. Further disclosed is a food product which includes Thraustochytrium, Schizochytrium, and mixtures thereof, and a component selected from flaxseed, rapeseed, soybean and avocado meal. Such a food product includes a balance of long chain and short chain omega-3 highly unsaturated fatty acids. The lipids containing these fatty acids can also be extracted and used in nutritional, pharmaceutical and industrial applications.

US Patent:

6541049, Apr 1, 2003

Filed:

Feb 19, 2001

Appl. No.:

09/789057

Inventors:

William R. Barclay - Boulder CO

Assignee:

Martek Biosciences Boulder Corporation - Boulder CO

International Classification:

C12P 764

US Classification:

426 7, 426 42, 426 43, 426 60, 426 61, 426491, 426492, 426580, 426585, 426581, 426601

Abstract:

The present invention relates to a process for producing arachidonic acid. In one embodiment, sect. microorganisms are cultured in fermentation medium, preferably containing a component of a complex nitrogen source. Further disclosed is a food product which includes sect. microorganisms or lipid isolated from such microorganisms to enhance the arachidonic acid content of the food product.

US Patent:

6568351, May 27, 2003

Filed:

Jul 19, 2002

Appl. No.:

10/181756

Inventors:

William R. Barclay - Boulder CO
Archimede Mordenti - Bologna, IT
Marco Tassinari - Bologna, IT
Alessandro Zotti - Lazzanochi Saurna, IT

Assignee:

Martek Biosciences Boulder Corporation - Boulder CO

International Classification:

A01K 102

US Classification:

119483, 424 933

Abstract:

The present invention provides a method for raising rabbits, in particular by feeding the rabbit with a feed containing a source of long-chain fatty acid. In this manner, mortality and the feed conversion rates are decreased while average daily weight gain and long-chain fatty acid content of rabbit meat are increased compared to a rabbit raised in the absence of the long-chain fatty acid source.

US Patent:

6607900, Aug 19, 2003

Filed:

Jan 26, 2001

Appl. No.:

09/771352

Inventors:

Richard B. Bailey - Del Mar CA
Don DiMasi - San Diego CA
Jon M. Hansen - Chula Vista CA
Peter J. Mirrasoul - San Diego CA
Craig M. Ruecker - San Diego CA
Tatsuo Kaneko - San Diego CA
William R. Barclay - Boulder CO

Assignee:

Martek Biosciences Boulder Corporation - Boulder CO

International Classification:

C12P 764

US Classification:

435134, 4352541, 435911

Abstract:

The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.

US Patent:

6749849, Jun 15, 2004

Filed:

Oct 5, 2001

Appl. No.:

09/972550

Inventors:

William R. Barclay - Boulder CO

Assignee:

Martek Biosciences Corporation - Columbia MD

International Classification:

A61K 3120

US Classification:

424 935, 426 7, 426 42, 426 43, 426 60, 426 61, 426491, 426492, 426580, 426581, 426601

Abstract:

The present invention relates to a process for producing arachidonic acid. In one embodiment, microorganisms are cultured in fermentation medium, preferably containing a component of a complex nitrogen source. Further disclosed is a food product which includes microorganisms or lipid isolated from such microorganisms to enhance the arachidonic acid content of the food product.

US Patent:

6977167, Dec 20, 2005

Filed:

Sep 13, 2002

Appl. No.:

10/244056

Inventors:

William R. Barclay - Boulder CO, US

Assignee:

Martek Biosciences Corporation - Columbia MD

International Classification:

C12N001/00
C12N001/12
C12P001/02
C12P007/62
C12P039/00

US Classification:

435134, 435 42, 435135, 435171, 435243, 4352571, 435946

Abstract:

A process for the heterotrophic or predominantly heterotrophic production of whole-celled or extracted microbial products with a high concentration of omega-3 highly unsaturated fatty acids, producible in an aerobic culture under controlled conditions using biologically pure cultures of heterotrophic single-celled fungi microorganisms of the order Thraustochytriales. The harvested whole-cell microbial product can be added to processed foods as a nutritional supplement, or to fish and animal feeds to enhance the omega-3 highly unsaturated fatty acid content of products produced from these animals. The lipids containing these fatty acids can also be extracted and used in nutritional, pharmaceutical and industrial applications.