Wilfried K Roth from La Jolla, CA, age 54

Novel Death Domain Proteins
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US Patent:

20030049702, Mar 13, 2003
Filed:

Nov 15, 2001
Appl. No.:

10/001254
Inventors:

John Reed - Rancho Santa Fe CA, US
Adam Godzik - San Diego CA, US
Krzysztof Pawlowski - Malmo, SE
Loredana Fiorentino - San Diego CA, US
Sug Lee - Seoul, KR
Wilfried Roth - La Jolla CA, US
Frank Stenner-Liewen - Homburg/Saar, DE
International Classification:

G01N033/574
C07H021/04
C12N009/64
C12P021/02
C12N005/06
US Classification:

435/007230, 435/069100, 435/226000, 435/320100, 435/325000, 536/023200
Abstract:

In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.

Novel Death Domain Proteins
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US Patent:

20050192427, Sep 1, 2005
Filed:

Mar 25, 2005
Appl. No.:

11/090425
Inventors:

John Reed - Rancho Santa Fe CA, US
Adam Godzik - San Diego CA, US
Krzysztof Pawlowski - Malmo, SE
Loredana Fiorentino - San Diego CA, US
Sug Lee - Seoul, KR
Wilfried Roth - La Jolla CA, US
Frank Stenner-Liewen - Saar, DE
Assignee:

The Burnham Institute - La Jolla CA
International Classification:

C07K014/705
C07K016/28
C12N005/06
US Classification:

530350000, 530388220, 435334000
Abstract:

In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.

Novel Death Domain Proteins
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US Patent:

20090011501, Jan 8, 2009
Filed:

Jun 5, 2008
Appl. No.:

12/134169
Inventors:

John C. Reed - San Diego CA, US
Adam Godzik - San Diego CA, US
Krzysztof Pawlowski - Malmo, SE
Loredana Fiorentino - San Diego CA, US
Sug Hyung Lee - Seoul, KR
Wilfried Roth - La Jolla CA, US
Frank Stenner-Liewen - Homburg/Saar, DE
Assignee:

THE BURNHAM INSTITUTE - La Jolla CA
International Classification:

C12N 5/06
C07K 14/00
C12N 15/11
C12N 15/00
US Classification:

435354, 530324, 536 234, 4353201
Abstract:

In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.

Novel Death Domain Proteins
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US Patent:

20110201780, Aug 18, 2011
Filed:

Mar 17, 2011
Appl. No.:

13/050848
Inventors:

John C. Reed - San Diego CA, US
Adam Godzik - San Diego CA, US
Krzysztof Pawlowski - Malmo, SE
Loredana Fiorentino - San Diego CA, US
Sug Hyung Lee - Seoul, KR
Wilfried Roth - San Diego CA, US
Frank Stenner-Liewen - Homburg/Saar, DE
Assignee:

SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE - La Jolla CA
International Classification:

C07K 14/295
US Classification:

530324, 530350
Abstract:

In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.

Wilfried K Roth