Warren Scott Grundfest

US Patent:

6697657, Feb 24, 2004

Filed:

Jun 28, 2000

Appl. No.:

09/605176

Inventors:

Vasilis Z. Marmarelis - Irvine CA
Warren S. Grundfest - Los Angeles CA

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

A61B 500

US Classification:

600323, 600317, 600329

Abstract:

Methods and devices for Laser Induced Fluorescence Attenuation Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) Spectrocopy, including, in particular, methods and devices for the detection of ischemia and hypoxia in biological tissue. The LIFAS method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.

US Patent:

RE39672, Jun 5, 2007

Filed:

Jan 23, 2002

Appl. No.:

10/056335

Inventors:

Vasilis Z. Marmarelis - Irvine CA, US
Warren S. Grundfest - Calabasas CA, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

G01N 21/64

US Classification:

2504612, 2504581, 600321, 600320, 600323, 356342

Abstract:

The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.

US Patent:

20060247529, Nov 2, 2006

Filed:

Apr 29, 2005

Appl. No.:

11/118166

Inventors:

Harold Rose - Tarzana CA, US
Robert Woskow - Encino CA, US
Warren Grundfest - Los Angeles CA, US
Spencer MacKay - Agoura Hills CA, US
David Rubenstein - Woodland Hills CA, US
James Elist - Beverly Hills CA, US
Alan Crawford - Burbank CA, US

International Classification:

A61B 8/14

US Classification:

600466000

Abstract:

An ultrasound scanning system and methods of using the same. In one preferred form, an ultrasound scanning system comprises an acoustic imaging catheter comprising an ultrasonic transducer, a motion control system and an imaging computer system for imaging a patient's genitourinary system. In another preferred form, an ultrasound scanning system is used for imaging a patient's prostate gland.

US Patent:

20070038097, Feb 15, 2007

Filed:

Jul 22, 2005

Appl. No.:

11/192464

Inventors:

Alan Crawford - Burbank CA, US
Spencer MacKay - Agoura Hills CA, US
James Elist - Beverly Hills CA, US
Warren Grundfest - Los Angeles CA, US
David Rubenstein - Woodland Hills CA, US
Harold Rose - Tarzana CA, US
Robert Woskow - Encino CA, US

International Classification:

A61B 8/00

US Classification:

600439000

Abstract:

An introducer for use with an ultrasonic imaging system. The introducer comprises a tubular member having a connecting end, a positioning end, and a central lumen, the connecting end including a coupling for attaching the introducer to an ultrasonic imaging system, and the positioning end comprising a plug or other structure that facilitates positioning of the introducer inside a urethra at a fixed anatomical landmark.

US Patent:

20090227994, Sep 10, 2009

Filed:

Aug 9, 2005

Appl. No.:

11/573422

Inventors:

Warren S. Grundfest - Los Angeles CA, US
Yaser M. Abdulraheem - Kuwait City, KW
Margaret Chiang - Los Angeles CA, US
Mario K. Furtado - Los Angeles CA, US
Kevin Geary - Union City CA, US
Chih-Kang Lin - Los Angeles CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61B 18/20
A61B 19/00

US Classification:

606 9, 606186

Abstract:

A device for removing compounds in tissue such as, for example, tattoo pigment compounds in skin tissue includes a detector for detecting the peak optical absorption of the compound, a laser source, wherein the wavelength is tuned or selected based on the peak optical absorption of the compound in the skin. The device further includes a delivery member for delivering radiation from the laser source to the tissue. Compounds such as tattoo pigment compounds are removed by detecting the peak optical absorption of the tattoo pigments or photofragments thereof in tissue with the detector. The wavelength of the laser source is adjusted based on the peak optical absorption of the compound in the tissue, and delivers radiation at the adjusted (or non-adjusted) wavelength from the laser source to the compound in the tissue with the delivery member.

US Patent:

20100137721, Jun 3, 2010

Filed:

Feb 10, 2010

Appl. No.:

12/703696

Inventors:

Harold B. Rose - Tarzana CA, US
Robert M. Woskow - Encino CA, US
Warren G. Grundfest - Los Angeles CA, US
Spencer L. MacKay - Agoura Hills CA, US
David J. Rubenstein - Woodland Hills CA, US
James J. Elist - Beverly Hills CA, US
Alan D. Crawford - Burbank CA, US

International Classification:

A61B 8/14

US Classification:

600463

Abstract:

An ultrasound scanning system and methods of using the same. In one preferred form, an ultrasound scanning system comprises an acoustic imaging catheter comprising an ultrasonic transducer, a motion control system and an imaging computer system for imaging a patient's genitourinary system. In another preferred form, an ultrasound scanning system is used for imaging a patient's prostate gland.

US Patent:

20100292706, Nov 18, 2010

Filed:

Apr 14, 2007

Appl. No.:

12/279982

Inventors:

Erik P. Dutson - Los Angeles CA, US
Warren Grundfest - Los Angeles CA, US
Adrienne Higa - Los Angeles CA, US
Chih-Hung King - Sharpsburg GA, US
Martin Culjat - Los Angeles CA, US

International Classification:

A61B 19/00

US Classification:

606130

Abstract:

A modular, scalable, layerable balloon actuator or actuator array. The miniaturized actuator array can be mounted on the hand controls of a surgical robotic system, and pressure or force input is applied to the surgeon's fingers. The input to the fingers is proportional to the applied force or pressure that is sensed on a separate sensor array, which is mounted on the surfaces of the object to be physically manipulated. The force is translated to pressure using a control system, which includes electronic and pneumatic components. The Novel enhanced haptic feedback system enables the detection of force and tactile information on tissues and sutures with high spatial and temporal resolution. This technology shortens the learning curve for MIS training, expands the application of MIS techniques in surgery, and enhances telementoring and teiesurgery applications. The actuator is modular scalable, Iayerable, compact, configurable, flexible, and conformable. It is therefore designed such that it can be adapted to future surgical robotic systems, and can be applied to prosthetics, orthotics, and persons with sensory neuropathy, as well as other robotic applications, simulating machines and apparatus and user-interfacing systems for video-gaming.

US Patent:

20130162949, Jun 27, 2013

Filed:

Aug 29, 2012

Appl. No.:

13/597947

Inventors:

Martin Culjat - Los Angeles CA, US
Priyamvada Tewari - Los Angeles CA, US
Jean L. Bourges - Paris, FR
Jean P. Hubschman - Los Angeles CA, US
Rahul S. Singh - Palo Alto CA, US
Zachary Taylor - Poway CA, US
Warren S. Grundfest - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 3/00

US Classification:

351221, 351246

Abstract:

A corneal hydration sensing system includes an illumination system configured to provide an illumination beam of terahertz radiation, an optical system arranged in an optical path of the illumination system to relay and direct at least a portion of the illumination beam of terahertz radiation onto a cornea of a subject and to receive at least a portion of terahertz radiation reflected from the cornea to provide a return beam of terahertz radiation, and a detection system arranged in an optical path of the return beam of terahertz radiation. The detection system is configured to provide a detection signal from detecting at least a portion of the return beam of terahertz radiation. The corneal hydration sensing system also includes a signal processing system configured to communicate with the detection system to receive the detection signal. The signal processing system processes the detection signal to provide a measure of an amount of hydration sensed in the cornea of the subject.

Author:

Warren S. Grundfest

ISBN #:

0815192592

Author:

Warren S. Grundfest

ISBN #:

0819416312

Author:

Warren S. Grundfest

ISBN #:

0819418560

Author:

Warren S. Grundfest

ISBN #:

0819427012

Author:

Warren S. Grundfest

ISBN #:

0819435279

Author:

Warren S. Grundfest

ISBN #:

0819439320

Author:

Warren S. Grundfest

ISBN #:

0819443549

Author:

Warren S. Grundfest

ISBN #:

0819456667