Walter K Herlihy

US Patent:

44763000, Oct 9, 1984

Filed:

Aug 4, 1983

Appl. No.:

6/520497

Inventors:

Walter C. Herlihy - Cambridge MA
David M. Epstein - Belmont MA

Assignee:

Repligen Corporation - Cambridge MA

International Classification:

C07H 1518

US Classification:

536 174

Abstract:

The subject invention concerns a novel process for preparing novel N-oxide compounds of O-. beta. -D-glucuronides of an anticholinergic compound containing a tertiary nitrogen. Examples of suitable glucuronide starting materials are O-. beta. -D-glucuronides of tropicamide, scopolamine, atropine, hyoscyamine, and the like. The novel process gives high yields of the desired N-oxides which are useful as UV filters.

US Patent:

50896059, Feb 18, 1992

Filed:

Mar 13, 1987

Appl. No.:

7/025466

Inventors:

Albert T. Profy - Cambridge MA
Margaret A. Belew - Medford MA
Walter C. Herlihy - Beverly MA

Assignee:

Repligen Corporation - Cambridge MA

International Classification:

C07K 1706
C07K 318

US Classification:

530402

Abstract:

The invention concerns unique immobilized immunoglobulin-binding protein materials which have a high binding capacity for immunoglobulins. Exemplified are preparations which have a high binding capacity for IgGl immunoglobulins. The preparations are made by covalently joining an immobilization support material to (a) an arginine-containing linker and (b) an immunoglobulin-binding protein material. The immunoglobulin-binding protein can be joined to the linker through an amide bond. Specifically disclosed is an immobilized protein A preparation. This immobilized protein A preparation has utility in the art of purifying monoclonal antibodies.

US Patent:

52603733, Nov 9, 1993

Filed:

Feb 18, 1992

Appl. No.:

7/837227

Inventors:

Albert T. Profy - Cambridge MA
Margaret A. Belew - Medford MA
Walter C. Herlihy - Beverly MA

Assignee:

Repligen Corporation - Cambridge MA

International Classification:

C07K 1706

US Classification:

525 541

Abstract:

The invention concerns unique immobilized immunoglobulin-binding protein materials which have a high binding capacity for immunoglobulins. Exemplified are preparations which have a high binding capacity for IgGl immunoglobulins. The preparations are made by covalently joining an immobilization support material to (a) an arginine-containing linker and (b) an immunoglobulin-binding protein material. The immunoglobulin-binding protein can be joined to the linker through an amide bond. Specifically disclosed is an immobilized protein A preparation. This immobilized protein A preparation has utility in the art of purifying monoclonal antibodies.

US Patent:

47768576, Oct 11, 1988

Filed:

Nov 21, 1986

Appl. No.:

6/933649

Inventors:

James Carroll - Cambridge MA
Cynthia D. Millis - Vancouver, CA
Walter C. Herlihy - Beverly MA

Assignee:

Repligen Corporation - Cambridge MA

International Classification:

A61K 713
A61K 742
A61K 744

US Classification:

8423

Abstract:

The invention concerns a new system to dye hair and/or skin. The system comprises the use of a hydroxyindole dye precursor and sodium periodate. Advantageously, this dye system allows the dye to penetrate inside the hair fiber without coating the hair shaft and, thus, give a more pleasing and stable dye result.

US Patent:

47463228, May 24, 1988

Filed:

May 11, 1987

Appl. No.:

7/052172

Inventors:

Walter C. Herlihy - Watertown MA

Assignee:

Repligen Corporation - Cambridge MA

International Classification:

A61K 713

US Classification:

8405

Abstract:

The subject invention concerns novel dye compositions and a process for dyeing keratinous fibers, for example, hair, to give a pleasing and stable colored product. The dye composition is a novel combination of three elements to give a dye that, unexpectedly, has highly desirable dyeing properties. This unique combination comprises (1) a suitable organic compound to assist dye dispersion, (2) dye precursors including dopamine, D-dopa, L-dopa, D,L-dopa, or analogs thereof, and (3) iodate or periodate. Desired color variations can be obtained by the use of appropriate color modifiers.

US Patent:

44711115, Sep 11, 1984

Filed:

Jul 14, 1982

Appl. No.:

6/398212

Inventors:

Walter C. Herlihy - Cambridge MA

Assignee:

Repligen Corporation - Cambridge MA

International Classification:

A61K 3170
C12P 1944
C07H 1518

US Classification:

536 174

Abstract:

An in vitro enzymatic process which efficiently converts ester-containing anticholinergics having a primary alcohol to their corresponding novel O-glucuronic acid derivatives. These novel glucuronides are useful as antiperspirants.

US Patent:

44436084, Apr 17, 1984

Filed:

May 24, 1982

Appl. No.:

6/381528

Inventors:

Walter C. Herlihy - Cambridge MA
Thomas H. Fraser - Newtonville MA

Assignee:

Repligen Corporation - Cambridge MA

International Classification:

C07H 1526

US Classification:

546268

Abstract:

An in vitro enzymatic process which efficiently converts (+,-)-tropicamide to essentially pure (+), (-)-tropicamide O-. beta. -D-glucuronide. This product is then separated, advantageously, into the novel compounds (+)-tropicamide O-. beta. -D-glucuronide and (-)-tropicamide O-. beta. -D-glucuronide. The products disclosed herein absorb ultraviolet light, and, thus, can be incorporated into suitable plastic films which are then useful for screening out harmful ultraviolet radiation for the protection of packaged goods. Also the products can be used to protect the skin against burning by sunlight.

US Patent:

46297928, Dec 16, 1986

Filed:

Sep 9, 1985

Appl. No.:

6/773714

Inventors:

Walter C. Herlihy - Cambridge MA
Thomas H. Fraser - Newtonville MA

Assignee:

Repligen Corporation - Cambridge MA

International Classification:

C07H 1526
B01D 1508

US Classification:

546268

Abstract:

An in vitro enzymatic process which efficiently converts (+,-)-tropicamide to essentially pure (+), (-)-tropicamide O-. beta. -D-glucuronide. This product is then separated, advantageously, into the novel compounds (+)-tropicamide O-. beta. -D-glucuronide and (-)-tropicamide O-. beta. -D-glucuronide. The products disclosed herein absorb ultraviolet light, and, thus, can be incorporated into suitable plastic films which are then useful for screening out harmful ultraviolet radiation for the protection of packaged goods. Also, the products can be used to protect the skin against burning by sunlight.