Walter U Gerhard

US Patent:

7354589, Apr 8, 2008

Filed:

Mar 29, 2005

Appl. No.:

11/093107

Inventors:

Walter Gerhard - Philadelphia PA, US
Laszlo Otvos, Jr. - Audubon PA, US

Assignee:

The Wistar Institute - Philadelphia PA

International Classification:

A61K 39/385
C07K 17/00

US Classification:

4241931, 530403

Abstract:

The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections. The multiple antigenic agents of the invention contain at least one of a B cell determinant, a T cell determinant, or a targeting molecule attached to a core peptide composed of Lys-Gly repeats.

US Patent:

7527798, May 5, 2009

Filed:

Jan 14, 2004

Appl. No.:

10/541771

Inventors:

Walter Gerhard - Philadelphia PA, US
Laslo Otvos - Audubon PA, US

Assignee:

The Wistar Institute - Philadelphia PA

International Classification:

A61K 39/385
A61K 39/145
C07K 17/00

US Classification:

4241931, 42419611, 4242091, 530403

Abstract:

The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections.

US Patent:

7740860, Jun 22, 2010

Filed:

Mar 13, 2006

Appl. No.:

11/910025

Inventors:

Walter Gerhard - Philadelphia PA, US
Laszlo Otvos, Jr. - Audubon PA, US

Assignee:

The Wistar Institute - Philadelphia PA

International Classification:

A61K 39/385
A61K 39/145
C07K 17/00

US Classification:

4241931, 42419611, 4242091, 530403

Abstract:

The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections.

US Patent:

20040247610, Dec 9, 2004

Filed:

Jan 14, 2004

Appl. No.:

10/757692

Inventors:

Walter Gerhard - Philadelphia PA, US
Laszlo Otvos - Audubon PA, US

International Classification:

C12Q001/68
A61K039/00
C07K009/00

US Classification:

424/185100, 530/322000, 530/324000

Abstract:

The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections.

US Patent:

41962656, Apr 1, 1980

Filed:

Aug 11, 1978

Appl. No.:

5/933092

Inventors:

Hilary Koprowski - Wynnewood PA
Walter U. Gerhard - Philadelphia PA
Carlo M. Croce - Philadelphia PA

Assignee:

The Wistar Institute - Philadelphia PA

International Classification:

A01N 102
A61K 3942

US Classification:

435 2

Abstract:

Continuous cell lines of genetically stable fused cell hybrids capable of producing large amounts of monoclonal antibodies against specific viruses and their antigenic determinants have been developed. The cell lines are fused cell hybrids between viral antibody producing cells and myeloma cells. Fused cell hybrids between influenza virus-primed mouse spleen cells and mouse myeloma cells can be maintained indefinitely in culture and continue to produce large amounts of anti-influenza antibody.