Walter G Bottje from 3841 E Skillern Rd, Fayetteville, AR 72703, age 70, Phone: 479 442-8941

Us Patents

Compositions And Methods Of Enhancing Immune Responses
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US Patent:

8604178, Dec 10, 2013
Filed:

Sep 18, 2007
Appl. No.:

12/441851
Inventors:

Walter Bottje - Fayetteville AR, US
Billy Hargis - Fayetteville AR, US
Luc Berghman - College Station TX, US
Young Min Kwon - Springdale AR, US
Kimberly Cole - Raymond OH, US
Mandy Cox - Fayetteville AR, US
Sherryll Layton - Fayetteville AR, US
Assignee:

The Board of Trustees of the University of Arkansas - Little Rock AR
The Texas A&M University of System - TAMU, College Station TX
International Classification:

C07H 21/02
A61K 49/00
A61K 39/112
US Classification:

536 237, 536 231, 424 91, 424 92, 4242341, 4242581
Abstract:

Provided herein are 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.

Blood And Tissue Sample Assessment Of Mitochondrial Function And Biochemistry As A Tool For Selection For Feed Efficiency And Other Production Parameters
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US Patent:

20060154255, Jul 13, 2006
Filed:

Dec 27, 2003
Appl. No.:

10/745874
Inventors:

Walter Bottje - Fayetteville AR, US
Neil Pumford - Fayetteville AR, US
Ron Okimoto - Fayetteville AR, US
Mohammad Iqbal - Nottinham MD, US
International Classification:

C12Q 1/68
G06F 19/00
US Classification:

435006000, 702019000
Abstract:

The present invention provides methods for predicting feed efficiency in animals by correlating the association of mitochondrial function with feed efficiency. In one embodiment, the invention provides a method for determining feed efficiency comprising comparing proteins patterns and activity levels with antibody interaction of proteins associated with mitochondrial function and feed efficiency. In an alternative embodiment, the present invention also provides methods for predicting feed efficiency in animals by identifying animals having genetic mutations or polymorphisms that are associated with mitochondrial function and feed efficiency.

Methods And Systems For Detection Of Contaminants
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US Patent:

20100120016, May 13, 2010
Filed:

Aug 31, 2007
Appl. No.:

12/439462
Inventors:

Yanbin Li - Fayetteville AR, US
Billy Hargis - Fayetteville AR, US
Steve Tung - Fayetteville AR, US
Luc Berghman - Colege Station TX, US
Walter Bottje - Fayetteville AR, US
Ronghui Wang - Fayetteville AR, US
Zunzhong Ye - Fayetteville AR, US
Madhukar Varshney - Fayetteville AR, US
Balaji Srinivasan - Fayetteville AR, US
International Classification:

C12Q 1/70
US Classification:

435 5
Abstract:

An impedance biosensor for detecting a contaminant in a starting material, the biosensor comprising a housing, an input device supported by the housing, an output device supported by the housing, a microfluidic cell supported by the housing, the starting material being engagable with the microfluidic cell, and an impedance analyzer supported by the housing and operable to measure impedance of the starting material to detect the presence of a contaminant.

Compositions And Methods Of Enhancing Immune Responses To Eimeria
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US Patent:

20110111015, May 12, 2011
Filed:

Nov 3, 2008
Appl. No.:

12/740608
Inventors:

Walter Bottje - Fayetteville AR, US
Billy Hargis - Fayetteville AR, US
Luc Berghman - College Station TX, US
Young Min Kwon - Springdale AR, US
Kimberly Cole - Raymond OH, US
Mandy Cox - Fayetteville AR, US
Sherryll Layton - Rogers AR, US
Said El-Ashram - Guelph, CA
John Barta - Guelph, CA
Guillermo Tellez - Fayetteville AR, US
International Classification:

A61K 9/127
A61K 39/00
A61K 39/12
A61K 39/02
A61K 39/112
A61K 39/07
A61K 39/108
A61K 39/002
A61K 39/012
A61K 39/015
A61P 37/04
A61P 33/02
US Classification:

424450, 4241841, 4241851, 4242041, 4242341, 4242581, 4242461, 4242571, 4242691, 4242711, 4242731, 4242721
Abstract:

Vaccines comprising TRAP polypeptides and vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD4Q. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.

Compositions And Methods Of Enhancing Immune Responses To Flagellated Bacterium
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US Patent:

20110159026, Jun 30, 2011
Filed:

Oct 30, 2008
Appl. No.:

12/740631
Inventors:

Walter Bottje - Fayetteville AR, US
Billy Hargis - Fayetteville AR, US
Luc Berghman - College Station TX, US
Young Min Kwon - Springdale AR, US
Kimberly Cole - Raymond OH, US
Mandy Cox - Fayetteville AR, US
Sherryll Layton - Rogers AR, US
Assignee:

THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSA - Little Rock AR
International Classification:

A61K 39/112
A61P 37/04
A61P 31/04
US Classification:

4241901, 4241851, 4242581
Abstract:

Vaccines comprising fliC and CD 154 polypeptides and vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.

Vaccine Vectors And Methods Of Enhancing Immune Responses
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US Patent:

20120282291, Nov 8, 2012
Filed:

Jan 21, 2011
Appl. No.:

13/574504
Inventors:

Luc Berghman - College Station TX, US
Walter Bottje - Fayetteville AR, US
Billy Hargis - Fayetteville AR, US
Sherryll Layton - Rogers AR, US
Assignee:

THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS - Little Rock AR
THE TEXAS A&M UNIVERSITY SYSTEM - College Station TX
International Classification:

A61K 39/145
A61P 31/16
C12N 1/21
US Classification:

4241921, 43525231, 4242001
Abstract:

Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.

Compositions And Methods For Increasing Poultry Hatchability And Early Performance
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US Patent:

20130116174, May 9, 2013
Filed:

Jul 11, 2011
Appl. No.:

13/809450
Inventors:

Billy Hargis - Fayetteville AR, US
Walter Bottje - Fayetteville AR, US
Assignee:

The Board of Trustees of the University of Arkansas - Little Rock AR
International Classification:

A61K 38/17
A61K 31/718
US Classification:

514 57
Abstract:

Compositions and methods of improving poultry hatch health are provided herein. Poultry hatch health and hatchability may be improved by administering compositions in ovo prior to hatch. The compositions include iodinated tyrosine-containing proteins, suitably iodinated casein, and carbohydrates.

Use Of L-Arginine And Salts Thereof In Drinking Water For The Prevention And/Or Treatment Of Pulmonary Hypertension Syndrome In Avians
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US Patent:

58957880, Apr 20, 1999
Filed:

Jan 31, 1997
Appl. No.:

8/792875
Inventors:

Robert F. Wideman - Fayetteville AR
Walter G. Bottje - Fayetteville AR
Michael T. Kidd - Chesterfield MO
Assignee:

The Board of Trustees of the University of Arkansas - Little Rock AR
International Classification:

A61K 31155
US Classification:

514565
Abstract:

A method of treating or preventing pulmonary hypertension syndrome in avians, generally including administering a drinking water containing L-arginine compound to the avian.

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Walter Bottje

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Walter G Bottje

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Us Patents

Compositions And Methods Of Enhancing Immune Responses

Blood And Tissue Sample Assessment Of Mitochondrial Function And Biochemistry As A Tool For Selection For Feed Efficiency And Other Production Parameters

Methods And Systems For Detection Of Contaminants

Compositions And Methods Of Enhancing Immune Responses To Eimeria

Compositions And Methods Of Enhancing Immune Responses To Flagellated Bacterium

Vaccine Vectors And Methods Of Enhancing Immune Responses

Compositions And Methods For Increasing Poultry Hatchability And Early Performance

Use Of L-Arginine And Salts Thereof In Drinking Water For The Prevention And/Or Treatment Of Pulmonary Hypertension Syndrome In Avians

Resumes

Walter Bottje

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Walter Bottje