Virginia B Kraus

US Patent:

20050124071, Jun 9, 2005

Filed:

Sep 29, 2004

Appl. No.:

10/952638

Inventors:

Virginia Kraus - Hillsborough NC, US

International Classification:

G06F019/00
G01N033/48
G01N033/50
G01N033/20

US Classification:

436084000, 702019000

Abstract:

The present invention provides a method of determining, in a sample, the proportion of a total amount of a molecule that is derived from catabolism due to the presence of age-related molecular alterations on the molecule, comprising: a) determining the total amount of the molecule in the sample; b) determining the amount of the molecule in the sample that contains D-aspartate; and c) calculating the proportion of the amount of the molecule of step (b) relative to the total amount of the molecule as determined in step (a), thereby determining the proportion of the total amount of the molecule that is derived from catabolism due to the presence of age-related molecular alterations in the molecule. Further provided is a method of diagnosing a musculoskeletal, arthritic or joint disorder in a subject and/or identifying a subject at risk for developing such a disorder, comprising: a) measuring an amount of D-aspartate and/or an advanced glycation end product in a sample of the subject; and b) comparing the amount of D-aspartate and/or advanced glycation end product in the sample of (a) with an amount of D-aspartate and/or advanced glycation end product in a sample of a control subject, whereby an increased amount of D-aspartate and/or advanced glycation end product in the sample of the subject as compared to the amount of D-aspartate and/or advanced glycation end product in the sample of the control subject is diagnostic of a musculoskeletal, arthritic or joint disorder in the subject and/or identifies a subject at risk of developing such a disorder.

US Patent:

20070009602, Jan 11, 2007

Filed:

Jun 21, 2006

Appl. No.:

11/472113

Inventors:

Lori Setton - Durham NC, US
Ashutosh Chilkoti - Durham NC, US
Virginia Kraus - Hillsborough NC, US
Helawe Betre - Durham NC, US
Matthew Dreher - Durham NC, US

International Classification:

A61K 39/395
A61K 9/14
A61M 31/00

US Classification:

424486000, 424145100, 424078270, 604500000

Abstract:

A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.

US Patent:

20080305039, Dec 11, 2008

Filed:

Apr 21, 2006

Appl. No.:

11/911679

Inventors:

Virginia Byers Kraus - Hillsborough NC, US
Amy Lynn McNulty - Bahama NC, US
Eric John Toone - Durham NC, US

International Classification:

A61K 51/04
A61K 31/675
A61K 31/665
A61K 49/00
A61K 31/70
A61K 31/7088

US Classification:

424 165, 514 89, 514 99, 514 54, 514 44, 424 96

Abstract:

Compounds of the formula: are described wherein: Ais ascorbic acid, dehydroascorbic acid, ascorbyl-2-phosphate, an analog thereof, or a salt thereof; L is a linking group coupled to Aat the C5 or C6 position thereof; and Bis an active agent such as an imaging agent or therapeutic agent (e.g. a bisphosphonate), along with pharmaceutically acceptable salts and prodrugs thereof. The compounds are useful for, among other things, improving cartilage uptake of active agents administered for joint diseases such as osteoarthritis and rheumatoid arthritis, and for improving gastrointestinal absorption of bisphosphonates.

US Patent:

20110236384, Sep 29, 2011

Filed:

Jan 24, 2011

Appl. No.:

13/012475

Inventors:

Lori A. SETTON - Durham NC, US
Ashutosh Chilkoti - Durham NC, US
Virginia B. Kraus - Hillsborough NC, US
Helawe Betre - Durham NC, US
Matthew R. Dreher - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

A61K 38/16
A61K 39/395
A61P 19/02

US Classification:

4241341, 514 212, 514 167, 514 168

Abstract:

A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.

US Patent:

20120028369, Feb 2, 2012

Filed:

Jun 29, 2011

Appl. No.:

13/172300

Inventors:

Philip A. BAND - West Orange NJ, US
Hans-Georg WISNIEWSKI - Riverdale NY, US
Virginia Byers Kraus - Hillsborough NC, US

Assignee:

DUKE UNIVERSITY MEDICAL CENTER - Durham NC
NEW YORK UNIVERSITY - New York NY

International Classification:

G01N 33/53

US Classification:

436501

Abstract:

This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the medium with a fluid sample from a subject with an inflammatory condition, where the fluid sample comprises proteins or proteoglycans and a transfer agent; incubating the fluid sample with the medium under conditions effective for the transfer agent in the fluid sample to mediate transfer of heavy chains from the proteins or proteoglycans to the hyaluronan or a fragment thereof to form a complex; detecting, using an antibody, occurrence levels of the complex; and comparing occurrence levels of the complex from said detecting to a reference standard to predict progression of an inflammatory condition in the subject. Also disclosed are methods of tailoring treatment of an inflammatory condition and quantifying local inflammatory activity in a body fluid.

US Patent:

20120114211, May 10, 2012

Filed:

Nov 8, 2011

Appl. No.:

13/291919

Inventors:

Virginia Byers KRAUS - Durham NC, US
H. Cecil CHARLES - Durham NC, US
Sheng Chu WANG - Durham NC, US
Sheng FENG - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

G06K 9/00

US Classification:

382131, 382128, 382132

Abstract:

Example systems and methods of generating an indicator of osteoarthritis (OA) progression are described. Fractal dimension curves are generated for horizontal and vertical trabecular components associated with a region of interest of a joint image. A statistical model is used to model shapes of the fractal dimension curves and a predictor of OA progression is calculated based on shape parameters of the statistical model.

US Patent:

20120315655, Dec 13, 2012

Filed:

Feb 22, 2011

Appl. No.:

13/580555

Inventors:

Virginia Kraus - Durham NC, US
Christopher McCudden - Durham NC, US
Jonathan Catterall - Durham NC, US

Assignee:

DUKE UNIVERSIY - Durham NC

International Classification:

G01N 33/53
C07K 16/00

US Classification:

435 794, 435 792, 5303871

Abstract:

The present invention relates, in general, to biomarkers of musculoskeletal disease and, in particular, to methods of as diagnosing musculoskeletal disease, and/or predicting disease progression, by assaying for such biomarkers. The invention further relates to compounds and compositions suitable for use in such methods.

US Patent:

20150204888, Jul 23, 2015

Filed:

Nov 10, 2014

Appl. No.:

14/537732

Inventors:

Philip A. BAND - West Orange NJ, US
Hans-Georg WISNIEWSKI - Riverdale NY, US
Virginia BYERS KRAUS - Hillsborough NC, US

Assignee:

DUKE UNIVERSITY MEDICAL CENTER - Durham NC
NEW YORK UNIVERSITY - New York NY

International Classification:

G01N 33/68

Abstract:

This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the medium with a fluid sample from a subject with an inflammatory condition, where the fluid sample comprises proteins or proteoglycans and a transfer agent; incubating the fluid sample with the medium under conditions effective for the transfer agent in the fluid sample to mediate transfer of heavy chains from the proteins or proteoglycans to the hyaluronan or a fragment thereof to form a complex; detecting, using an antibody, occurrence levels of the complex; and comparing occurrence levels of the complex from said detecting to a reference standard to predict progression of an inflammatory condition in the subject. Also disclosed are methods of tailoring treatment of an inflammatory condition and quantifying local inflammatory activity in a body fluid.

Author:

Virginia Byers Kraus

ISBN #:

0762104767

Author:

Virginia Byers Kraus

ISBN #:

0762105399