Viola T Kung

US Patent:

62911694, Sep 18, 2001

Filed:

Mar 30, 1999

Appl. No.:

9/281532

Inventors:

John D. Olson - Sunnyvale CA
Robert F. Zuk - Burlingame CA
Richard D. Armenta - Sunnyvale CA
Charles R. Burke - Palo Alto CA
Viola T. Kung - Menlo Park CA
Edward L. Sheldon - Menlo Park CA

Assignee:

Molecular Devices Corporation - Sunnyvale CA

International Classification:

C12Q 168
C07H 1900
C07H 2100
G01N 33566

US Classification:

435 6

Abstract:

The present invention encompasses a capture membrane comprising a porous filter membrane having a hapten bound directly or indirectly to the membrane wherein complexes formed by specific binding having an anti-hapten bound to a binding member of the specifically binding complex are removed from a solution by the hapten as the solution passes through the membrane. In the preferred embodiment biotin is the hapten and avidin or streptavidin is the anti-hapten.

US Patent:

47629150, Aug 9, 1988

Filed:

Jan 18, 1985

Appl. No.:

6/692679

Inventors:

Viola T. Kung - Menlo Park CA
Carl T. Redemann - Walnut Creek CA

Assignee:

Liposome Technology, Inc. - Menlo Park CA

International Classification:

A61K 3900
A61K 942
A61J 500

US Classification:

530405

Abstract:

A lipid coupling reagent for use in coupling amine-containing molecules, such as proteins, to liposomes. The reagent includes phosphatidylethanolamine coupled to a 3-20 atom carbon-containing spacer arm terminating at a carboxyl or thiocarboxyl group. Also disclosed are liposomes prepared to include between about 1 and 20 mole percent of the coupling reagent, and liposomes containing surface arrays of proteins attached to the liposomes through the coupling reagent.

US Patent:

56143680, Mar 25, 1997

Filed:

Dec 23, 1994

Appl. No.:

8/363608

Inventors:

Vartan Ghazarossian - Menlo Park CA
Viola T. Kung - Menlo Park CA
Robert F. Zuk - Burlingame CA

Assignee:

Molecular Devices Corporation - Sunnyvale CA

International Classification:

G01N 33543

US Classification:

435 75

Abstract:

Compounds and methods for detecting the incorporation of a hapten into a protein or macromolecule are disclosed. The compounds comprise haptens bound directly or indirectly to a chromophoric group and a macromolecule-reactive group, whereby incorporation of the hapten into a protein or other macromolecule may be detected.

US Patent:

46364790, Jan 13, 1987

Filed:

Apr 20, 1983

Appl. No.:

6/486793

Inventors:

Francis J. Martin - San Francisco CA
Viola T. Kung - Menlo Park CA

Assignee:

Cooper-Lipotech, Inc. - Menlo Park CA

International Classification:

G01N 33546
G01N 33555

US Classification:

436533

Abstract:

An enhanced agglutination assay method for determination of a multivalent analyte is disclosed. Analyte is added to agglutinatable particles coated with anti-analyte molecules to produce particle agglutination. The extent of agglutination is enhanced by mixing the particles and analyte with an analyte-binding reagent composed of lipid bodies. The reagent bodies act by promoting multiple analyte bridge connections between individual bridged particles and a reagent body. Also disclosed is a kit containing such particles and reagent.

US Patent:

49786083, Dec 18, 1990

Filed:

Sep 4, 1987

Appl. No.:

7/093361

Inventors:

Viola T. Kung - Menlo Park CA
Peter A. Nagainis - San Jose CA

Assignee:

Molecular Devices Corporation - Palo Alto CA

International Classification:

G01N 3353
G01N 3300
G01N 33566
C12Q 168

US Classification:

435 6

Abstract:

Picogram amounts of DNA can be detected in a sample by the use of high affinity single-stranded DNA binding proteins. The assay is applicable not only to pure DNA samples but also to samples containing significant amounts of protein.

US Patent:

50117700, Apr 30, 1991

Filed:

Jul 24, 1990

Appl. No.:

7/558252

Inventors:

Viola T. Kung - Menlo Park CA
Peter A. Nagainis - San Jose CA
Edward L. Sheldon - Menlo Park CA

Assignee:

Molecular Devices, Inc. - Palo Alto CA

International Classification:

C12Q 118
C12Q 100
G01N 3353
C12N 1102

US Classification:

435 6

Abstract:

Picogram amounts of DNA can be detected in a sample by the use of high-affinity, single-stranded DNA binding proteins. The assay is applicable not only to pure DNA samples but also to samples containing significant amounts of protein.

US Patent:

55277152, Jun 18, 1996

Filed:

Mar 10, 1994

Appl. No.:

8/208871

Inventors:

Viola T. Kung - Menlo Park CA
Mary J. Cerelli - Burlingame CA
Yuri Daniloff - Mountain View CA
Robert F. Zuk - Burlingame CA

Assignee:

Metra Biosystems, Inc. - Mountain View CA

International Classification:

G01N 3353

US Classification:

436547

Abstract:

A method of assaying a human urine sample, by measuring a concentration of pyridinium crosslinks from which the concentration of total hydrolysed pyridinoline in the sample can be determined, is disclosed. In the method, a urine sample is reacted with an anti-Pyd antibody reagent which preferably has a ratio of reactivity toward native free pyridinoline and urinary pyridinoline peptides larger than 1,000 daltons in molecular weight, of greater than 10:1. By measuring the extent of immunocomplex formed by the reaction, the concentration of total hydrolysed pyridinoline in the sample can be calculated. Also disclosed are an antibody reagent and kit which can be used in the method.

US Patent:

51121344, May 12, 1992

Filed:

Jan 8, 1991

Appl. No.:

7/639313

Inventors:

Calvin Y. H. Chow - Portola Valley CA
Gillian M. Humphries - Los Altos CA
Viola T. Kung - Menlo Park CA
Michael M. Lacy - Ben Lomand CA

Assignee:

Molecular Devices Corporation - Menlo Park CA

International Classification:

G01N 2131
G01N 2159

US Classification:

356427

Abstract:

A multibeam photometric measuring device includes a light assembly comprising a single modulated light source along with a filter assembly for passing only a desired band of wavelengths and an optical system for suitably focusing light from the light source. A plurality of light transmitting means accept light and transmit it individually to each of the plurality of sites disposed on a multi-well sample plate. Enhancement of color distribution resulting from chromogenic reactions is provided by automatic agitation of the reacting agents within the sample wells before a reading is taken at each of the sampling intervals of a kinetic measurement sequence.