Vera Y Matrosova

US Patent:

20160199408, Jul 14, 2016

Filed:

Oct 22, 2015

Appl. No.:

14/920765

Inventors:

- Bethesda MD, US
- Rockville MD, US
Vera Y. MATROSOVA - Rockville MD, US
Rodney L. LEVINE - Rockville MD, US
Nancy B. WEHR - Bethesda MD, US

International Classification:

A61K 33/32
A61K 35/74
A61K 45/06
A61K 31/7076
A61K 31/7072

Abstract:

This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e g., manganese) to a subject in need thereof. The compositions may comprise extracts.