Varavani J Dwarki from 1 Foxhill Dr, Southborough, MA 01772, age 69, Phone: 508 481-8384

Vehicle Records

Varavani Dwarki
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Address:

60 Lily Pond Ln, Chester Sprgs, PA 19425
Phone:

484 865-8970
VIN:

2T1BR30EX7C726203
Make:

TOYOTA
Model:

COROLLA
Year:

2007

Us Patents

Compositions And Methods For Polynucleotide Delivery
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US Patent:

6468986, Oct 22, 2002
Filed:

Jul 21, 2000
Appl. No.:

09/620925
Inventors:

Ronald N. Zuckermann - Berkeley CA
Varavani Dwarki - Alameda CA
Michael A. Innis - Moraga CA
John E. Murphy - Oakland CA
Fred E. Cohen - San Francisco CA
Tetsuo Uno - San Francisco CA
Assignee:

Chiron Corporation - Emeryville CA
International Classification:

A61K 4800
US Classification:

514 44, 424486, 424450, 4353201, 435325, 435 914, 435455
Abstract:

This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.

Aav Vectors
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US Patent:

6521225, Feb 18, 2003
Filed:

Sep 2, 1997
Appl. No.:

08/921497
Inventors:

Arun Srivastava - Indianapolis IN
Selvarangan Ponnazhagan - Cleveland OH
Xu-Shan Wang - Carmel IN
Mervin C. Yoder - Indianapolis IN
Jaime Escobedo - Alamo CA
Varavani Dwarki - Alameda CA
Assignee:

Chiron Corporation - Emeryville CA
Advanced Research and Technology Institute - Bloomington IN
International Classification:

A61K 3500
US Classification:

424 932, 424 931
Abstract:

The present invention is directed to a recombinant adenovirus vector comprising two inverted terminal repeats (ITRs) each of which comprises a D-sequence having (i) from 5 to 15 native nucleotides and (ii) one or more deletions or substitutions therein.

Use Of Recombinant Gene Delivery Vectors For Treating Or Preventing Diseases Of The Eye
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US Patent:

6943153, Sep 13, 2005
Filed:

Sep 20, 2000
Appl. No.:

09/665493
Inventors:

Varavani J. Dwarki - Pittstown NJ, US
Katherine Rendahl - Berkeley CA, US
Shangzhen Zhou - Alameda CA, US
Sheldon S. Miller - Berkeley CA, US
Fei Wang - Albany CA, US
Assignee:

The Regents of the University of California - Oakland CA
Chiron Corporation - Emeryville CA
International Classification:

A01N043/04
A01N063/00
A61K031/70
A61K048/00
A61K039/23
A61K039/235
US Classification:

514 44, 424 9321, 4242331
Abstract:

Gene delivery vectors, such as, for example, recombinant adeno-associated viral vectors, and methods of using such vectors are provided for use in treating or preventing diseases of the eye.

Compositions And Methods For Polynucleotide Delivery
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US Patent:

7462592, Dec 9, 2008
Filed:

Oct 22, 2002
Appl. No.:

10/278751
Inventors:

Ronald N. Zuckermann - Berkeley CA, US
Varavani Dwarki - Alameda CA, US
Michael A. Innis - Moraga CA, US
John E. Murphy - Oakland CA, US
Fred E. Cohen - San Francisco CA, US
Tetsuo Uno - San Francisco CA, US
Assignee:

Novartis Vaccines and Diagnostics, Inc. - Emeryville CA
International Classification:

A01N 37/18
A61K 9/14
A61K 38/00
US Classification:

514 2, 424486, 530300
Abstract:

This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.

Materials And Methods For Simplified Aav Production
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US Patent:

20010034054, Oct 25, 2001
Filed:

Apr 24, 2001
Appl. No.:

09/841768
Inventors:

Varavani Dwarki - Alameda CA, US
Martha Ladner - Oakland CA, US
Jaime Escobedo - Alamo CA, US
International Classification:

C12N007/01
C12N007/02
C07H021/04
A61K048/00
C07K001/00
US Classification:

435/235100, 435/236000, 435/239000, 435/325000, 435/320100, 424/184100, 424/186100, 424/198100, 424/199100, 424/204100, 424/233100, 424/278100, 424/281100, 424/093200, 530/350000, 530/826000, 536/023100, 536/023500, 536/023720
Abstract:

The invention provides a method for producing purified replication-defective recombinant AAV virions. The method comprises introducing into a suitable host cell an AAV vector, an AAV helper construct and an adenoplasmid accessory construct into the host cell. The adenoplasmid accessory plasmid is composed adenovirus plasmid DNA unable to be packaged into adenoviral particles because it lacks packaging signal sequence(s) or it contains additional sequences making it too large to package. The host cell is cultured to produce crude rAAV virions and then lysed. The resulting cell lysate is applied to a chromatographic column containing sulfonated cellulose or subjected to cesium chloride equilibrium gradient centrifugation and the purified rAAV virions are recovered.

Methods And Compositions For Liver Specific Delivery Of Therapeutic Molecules Using Recombinant Aav Vectors
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US Patent:

20010051611, Dec 13, 2001
Filed:

Jul 24, 2001
Appl. No.:

09/912680
Inventors:

Arun Srivastava - Indianapolis IN, US
Selvarangan Ponnazhagan - Cleveland OH, US
Robert Schloemer - Indianapolis IN, US
Xu-Shan Wang - Carmel IN, US
Mervin Yoder - Indianapolis IN, US
Jaime Escobedo - Alamo CA, US
Varavani Dwarki - Alameda CA, US
Assignee:

Chiron Corporation.
International Classification:

A61K048/00
C12N015/861
US Classification:

514/044000, 435/320100
Abstract:

Provided are methods for selectively expressing therapeutic molecules, such as secretory proteins, antisense molecules and ribozymes, in the liver. The methods find use in treating hepatic diseases or conditions. The methods also find use in treating any disease or condition in which systemic administration of the therapeutic substance, for example, a secretory protein, is desired. The methods involve administering to a mammalian patient having a need for liver expression of a therapeutic molecule an AAV vector containing a therapeutically effective amount of the therapeutic molecule. Also provided are novel vectors employable in these methods.

Replication-Defective Recombinant Aav Virions
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US Patent:

20020132336, Sep 19, 2002
Filed:

Mar 15, 2002
Appl. No.:

10/099252
Inventors:

Varavani Dwarki - Alameda CA, US
Martha Baillie Ladner - Oakland CA, US
Jaime Escobedo - Alamo CA, US
Assignee:

Chiron Corporation - Emeryville CA
International Classification:

C12N007/00
C12N015/861
C07H021/02
C12P021/06
C12N007/02
C12N015/09
C12N015/70
C12N015/86
C07H021/04
C12N007/01
C12N015/00
C12N015/63
C12N015/74
US Classification:

435/235100, 435/456000, 435/239000, 435/320100, 435/069100, 536/023100
Abstract:

The invention provides a method for producing purified replication-defective recombinant AAV virions. The method comprises introducing into a suitable host cell an AAV vector, an AAV helper construct and an adenoplasmid accessory construct into the host cell. The adenoplasmid accessory plasmid is composed adenovirus plasmid DNA unable to be packaged into adenoviral particles because it lacks packaging signal sequence(s) or it contains additional sequences making it too large to package. The host cell is cultured to produce crude rAAV virions and then lysed. The resulting cell lysate is applied to a chromatographic column containing sulfonated cellulose or subjected to cesium chloride equilibrium gradient centrifugation and the purified rAAV virions are recovered.

Use Of Recombinant Gene Delivery Vectors For Treating Or Preventing Diseases Of The Eye
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US Patent:

20020194630, Dec 19, 2002
Filed:

Mar 4, 2002
Appl. No.:

10/090983
Inventors:

William Manning - Redwood City CA, US
Varavani Dwarki - Pittstown NJ, US
Katherine Rendahl - Berkeley CA, US
Shangzhen Zhou - Alameda CA, US
Laura McGee - Oakland CA, US
Dana Lau - Oakland CA, US
John Flannery - Berkeley CA, US
Sheldon Miller - Berkeley CA, US
Fei Wang - Albany CA, US
Adriana Di Polo - Outremont, CA
International Classification:

A61K048/00
A01K067/00
US Classification:

800/008000, 514/044000
Abstract:

Gene delivery vectors, such as, for example, recombinant adeno-associated viral vectors, and methods of using such vectors are provided for use in treating or preventing diseases of the eye.