Vaclav N Janout from 3605 Browning Ln, Bethlehem, PA 18017, age 73, Phone: 610 865-7760

Bisphosphonate-Prostatic Acid Phosphatase Inhibitor Conjugates To Treat Prostate Cancer Bone Metastasis
view source
US Patent:

20140045797, Feb 13, 2014
Filed:

Oct 16, 2013
Appl. No.:

14/055313
Inventors:

STEVEN L. REGEN - Allentown PA, US
VACLAV JANOUT - Bethlehem PA, US
Assignee:

LEHIGH UNIVERSITY - Bethlehem PA
MOUNT SINAI SCHOOL OF MEDICINE - New York NY
International Classification:

A61K 47/48
US Classification:

514101, 514108
Abstract:

The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for treating and inhibiting prostate cancer bone metastases, and determining whether a conjugate is useful for such treatment are also provided. In some instances, the bisphosphonate is alendronate, and it is covalently bonded to either tartaric acid or glyceric acid.

Bisphosphonate-Prostatic Acid Phosphatase Inhibitor Conjugates To Treat Prostate Cancer Bone Metastasis
view source
US Patent:

20110065672, Mar 17, 2011
Filed:

Sep 16, 2010
Appl. No.:

12/883662
Inventors:

ALEXANDER KIRSCHENBAUM - NEW YORK NY, US
ALICE C. LEVINE - NEW YORK NY, US
STEVEN L. REGEN - ALLENTOWN PA, US
VACLAV JANOUT - BETHLEHEM PA, US
Assignee:

MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY - NEW YORK NY
LEHIGH UNIVERSITY - BETHLEHEM PA
International Classification:

A61K 31/664
C07F 9/44
A61P 35/00
US Classification:

514108, 558155
Abstract:

The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for treating and inhibiting prostate cancer bone metastases, and determining whether a conjugate is useful for such treatment are also provided. In some instances, the bisphosphonate is alendronate, and it is covalently bonded to either tartaric acid or glyceric acid.

Reduced Toxicity Molecular Conjugates Of Anti-Fungal Agents
view source
US Patent:

20170042923, Feb 16, 2017
Filed:

Aug 10, 2016
Appl. No.:

15/233679
Inventors:

- Bethlehem PA, US
Vaclav Janout - Bethlehem PA, US
Yuming Yu - Bethlehem PA, US
International Classification:

A61K 31/7048
A61K 47/48
Abstract:

Compositions, compounds and methods are described for addressing both toxicity of membrane disruptive anti-microbial agents as well as poor transport of such agents across the blood-brain-barrier (BBB) via the use of molecular appendages including one or more facial amphiphiles. These molecules have in vitro anti-fungal activity that is very similar to that of the native drug but with hemolytic activity and toxicity towards mammalian cells that is greatly reduced.

Vaclav N Janout