Tongwen Wang

US Patent:

6906179, Jun 14, 2005

Filed:

Aug 10, 2001

Appl. No.:

09/927738

Inventors:

Tongwen Wang - Seattle WA, US

Assignee:

The General Hospital Corporation - MA

International Classification:

C07K016/18

US Classification:

5303871, 530350, 5303879, 435183

Abstract:

The invention provides novel compositions comprising a Smad protein and an isolated protein component of the proteasome-mediated degradation pathway. The invention also provides novel compositions comprising a Smad1 protein and a substrate for proteasome-mediated degradation. The invention also provides methods of screening for compounds that modulate the interaction between the proteins comprising these compositions. The invention also provides methods of screening for compounds that modulate the activity of the proteins comprising these compositions. The invention also provides methods of detecting proteasome-mediated degradation of novel Smad interacting proteins. A further aspect of the invention is a kit for detecting proteasome-mediated degradation of novel Smad interacting proteins. The invention also provides methods of treating diseases which are associated with aberrant levels of activity of a TGF-β superfamily member.

US Patent:

59122242, Jun 15, 1999

Filed:

Feb 21, 1997

Appl. No.:

8/803899

Inventors:

Patricia K. Donahoe - Weston MA
Tongwen Wang - Arlington MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

A61K 3133
A61K 3818

US Classification:

514 2

Abstract:

The present invention concerns the TGF-. beta. receptor-mediated signaling pathway. The invention is based on the unexpected finding that TGF-. beta. receptor-mediated signaling is inhibited by the cytoplasmic interactor FKBP12. The invention further concerns methods and pharmaceutical compositions for enhancing cellular response to TGF-. beta. ligands. A screening assay is also provided for identifying macrolide potentiators capable of binding FKBP12 and thereby blocking FKBP12-inhibition of TGF-. beta. receptor-mediated signaling.