A mucosal vaccine for the prevention or treatment of microbial infections is described that is capable of inducing vaccine antigen-specific immune responses in an organism without the addition of a mucosal adjuvant. The mucosal vaccine comprises a composite of a nanogel comprising a hydrophilic polysaccharide having a cationic functional group and a hydrophobic cholesterol added thereto as a side chain and a vaccine antigen. The vaccine is administered via a mucosal route.
- Tokyo, JP Hiroshi Kiyono - Tokyo, JP Yoshikazu Yuki - Tokyo, JP Tomonori Nochi - Chapel Hill NC, US
Assignee:
National University Corporation Tokyo Medical and Dental University - Tokyo
International Classification:
A61K 39/08
US Classification:
4242391, 4241841
Abstract:
A mucosal vaccine for the prevention or treatment of microbial infections is described that is capable of inducing vaccine antigen-specific immune responses in an organism without the addition of a mucosal adjuvant. The mucosal vaccine comprises a composite of a nanogel comprising a hydrophilic polysaccharide having a cationic functional group and a hydrophobic cholesterol added thereto as a side chain and a vaccine antigen. The vaccine is administered via a mucosal route.
Name / Title
Company / Classification
Phones & Addresses
Tomonori Nochi Pr
Japanese Language School of Ra Nonclassifiable Establishments · School/Educational Services · Schools and Educational Services, Nec, Nsk