Timothy A Thrailkill

US Patent:

20110081315, Apr 7, 2011

Filed:

Sep 24, 2010

Appl. No.:

12/890475

Inventors:

Brad Buckman - Oakland CA, US
John B. Nicholas - Redwood City CA, US
Leonid Beigelman - San Mateo CA, US
Vladimir Serebryany - Burlingame CA, US
Antitsa Dimitrova Stoycheva - Half Moon Bay CA, US
Timothy Thrailkill - San Francisco CA, US
Scott Seiwert - Pacifica CA, US

Assignee:

INTERMUNE, INC. - Brisbane CA

International Classification:

A61K 38/21
C07D 487/04
A61K 31/437
A61K 31/427
A61K 31/428
A61K 31/5377
A61K 31/445
A61K 31/506
A61K 31/4192
A61K 31/422
A61K 31/4725
A61K 31/522
A61K 31/498
C12N 9/99
C12N 5/02

US Classification:

424 855, 540460, 514303, 514369, 514367, 51421021, 5142332, 514322, 514256, 514359, 514374, 514309, 5142632, 514249, 435184, 424 857, 435375

Abstract:

The embodiments provide compounds of the general Formulae I, Ia, II, III, IV, V, VI-1, VI-2, VII, VIII, IX, X, XI, and XII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.