Timothy E Riedel

US Patent:

20070077571, Apr 5, 2007

Filed:

May 17, 2006

Appl. No.:

11/436720

Inventors:

Andrew Ellington - Austin TX, US
Michael Robertson - Austin TX, US
J. Cox - Austin TX, US
Timothy Riedel - Austin TX, US
Eric Davidson - Austin TX, US

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

Compositions and methods are provided to use regulatable aptazymes for controlling gene expression and in assays to detect the presence of ligands or to detect activation by an effector of an aptazyme bound to a solid support such as a substrate or multi-well plate. Regulatable aptazymes are ribozymes that are allosterically regulated by an effector molecule. Also disclosed are compositions and methods for automating the selection procedures of the present invention.

US Patent:

20040126882, Jul 1, 2004

Filed:

Sep 24, 2002

Appl. No.:

10/254568

Inventors:

Andrew Ellington - Austin TX, US
Jay Hesselberth - Seattle WA, US
Kristin Thompson - Arlington MA, US
Michael Robertson - Santa Cruz CA, US
Letha Sooter - Austin TX, US
Eric Davidson - Houston TX, US
J. Cox - Austin TX, US
Timothy Riedel - New Braunfels TX, US
Charles Wilson - Concord MA, US
Sharon Cload - Cambridge MA, US
Anthony Keefe - Cambridge MA, US

International Classification:

C07H021/02
C12N015/85

US Classification:

435/455000, 536/023100

Abstract:

Compositions and methods are provided to make, isolate, characterize and use regulatable, catalytically active nucleic acids (RCANA). The present invention is directed to RCANA that transduce molecular recognition into catalysis. Also, RCANAs according to the invention can be used as regulatory elements to control the expression of one or more genes in a metabolic pathway. RCANAs can also be used as regulated selectable markers to create a selective pressure favoring (or disfavoring) production of a targeted bioproduct.