Timothy M Harris

US Patent:

6388788, May 14, 2002

Filed:

Jun 15, 1999

Appl. No.:

09/333749

Inventors:

Timothy D. Harris - Toms River NJ
Richard L. Hansen - Pennington NJ
William Karsh - Plainsboro NJ
Neal A. Nicklaus - East Windsor NJ
Jay K. Trautman - Pennington NJ

Assignee:

Praelux, Inc. - Lawrenceville NJ

International Classification:

G02B 2608

US Classification:

359196, 359204, 359212, 359215, 359226, 359368, 359391, 250234

Abstract:

Methods and apparatus for screening large numbers of chemical compounds and performing a wide variety of fluorescent assays, including live cell assays. The methods utilize a laser linescan confocal microscope with high speed, high resolution and multi-wavelength capabilities and real time data-processing. Imaging may be done at video-rates and with use of ultraviolet illumination.

US Patent:

6400487, Jun 4, 2002

Filed:

Nov 28, 2000

Appl. No.:

09/724253

Inventors:

Timothy D. Harris - Toms River NJ
Richard L. Hansen - Pennington NJ
William Karsh - Plainsboro NJ
Neal A. Nicklaus - East Windsor NJ
Jay K. Trautman - Pennington NJ

Assignee:

Praelux, Inc. - Lawrenceville NJ

International Classification:

G02B 2608

US Classification:

359210, 359823, 2502012

Abstract:

Methods and apparatus for screening large numbers of chemical compounds and performing a wide variety of fluorescent assays, including live cell assays. The methods utilize a laser linescan confocal microscope with high speed, high resolution and multi-wavelength capabilities and real time data-processing. Imaging may be done at video-rates and with use of ultraviolet illumination.

US Patent:

7282337, Oct 16, 2007

Filed:

Apr 14, 2006

Appl. No.:

11/404695

Inventors:

Timothy D. Harris - Toms River NJ, US

Assignee:

Helicos BioSciences Corporation - Cambridge MA

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The invention provides methods for improving the accuracy of a sequencing-by-synthesis reaction by sequencing at least a portion of a template and at least a portion of template complementary sequence.

US Patent:

7767400, Aug 3, 2010

Filed:

Feb 3, 2008

Appl. No.:

12/025033

Inventors:

Timothy D. Harris - Toms River NJ, US

Assignee:

Helicos Biosciences Corporation - Cambridge MA

International Classification:

C12Q 1/68
C12M 1/34
C07H 21/04
C07H 21/00
G01N 31/00

US Classification:

435 6, 4352872, 536 231, 536 2433, 536 253, 536 2532, 702 20

Abstract:

The disclosure provides methods of generating paired reads in sequencing-by-synthesis process, particularly, in systems with relatively short read lengths (e. g. , 15-35bases), such as for example, in single molecule sequencing by synthesis. Several implementations of the methods are provided. Of particular advantage are the methods that permit re-sequencing of the template, which yields lower error rates. The invention further provides methods of using paired reads, for example, for positioning them over repeats or for assembly into large sequences, including whole genome assembly.

US Patent:

7790391, Sep 7, 2010

Filed:

Mar 28, 2008

Appl. No.:

12/058032

Inventors:

Timothy D. Harris - Toms River NJ, US

Assignee:

Helicos Biosciences Corporation - Cambridge MA

International Classification:

C12Q 1/68

US Classification:

435 6, 435 911, 435 912, 536 231, 536 221

Abstract:

The disclosure provides methods of reducing the range of representation levels of nucleic acid targets. The methods are particularly useful for multi-target analyses benefiting from a low variance of target representations, such as, e. g. , single molecule sequencing and/or heterozygous genotyping, and pathogen diagnosis. Two general methods are provided. In Method 1, starting concentrations of probes are adjusted. In Method 2, target-specific probes are “binned,” i. e. , several subsets of probes are selected based on similar representation levels. Thereafter, each subset of corresponding targets is extracted, with or without amplification, using a separate portion of the sample (i. e. , separate vessels).

US Patent:

7957911, Jun 7, 2011

Filed:

Feb 8, 2008

Appl. No.:

12/028345

Inventors:

Timothy D. Harris - Toms River NJ, US
Richard L. Hansen - Pennington NJ, US
William Karsh - Plainsboro NJ, US
Neal A. Nicklaus - East Windsor NJ, US
Jay K. Trautman - Pennington NJ, US

Assignee:

GE Healthcare Bio-Sciences Corp. - Piscataway NJ

International Classification:

G06F 19/00
G01N 33/48

US Classification:

702 19, 382130, 382133

Abstract:

Methods and apparatus for screening large numbers of chemical compounds and performing a wide variety of fluorescent assays, including live cell assays. The methods utilize a laser linescan confocal microscope with high speed, high resolution and multi-wavelength capabilities and real time data-processing. Imaging may be done at video-rates and with use of ultraviolet illumination.

US Patent:

20030036855, Feb 20, 2003

Filed:

Aug 16, 2002

Appl. No.:

10/227552

Inventors:

Timothy Harris - Toms River NJ, US
Richard Hansen - Pennington NJ, US
William Karsh - Plainsboro NJ, US
Neal Nicklaus - East Windsor NJ, US
Jay Trautman - Pennington NJ, US

Assignee:

Praelux Incorporated, a corporation of New Jersey

International Classification:

G06F019/00
G01N033/48
G01N033/50
G06K009/00

US Classification:

702/019000, 702/020000, 382/128000

Abstract:

Methods and apparatus for screening large numbers of chemical compounds and performing a wide variety of fluorescent assays, including live cell assays. The methods utilize a laser linescan confocal microscope with high speed, high resolution and multi-wavelength capabilities and real time data-processing. Imaging may be done at video-rates and with use of ultraviolet illumination.

US Patent:

20060012793, Jan 19, 2006

Filed:

Nov 16, 2004

Appl. No.:

10/990167

Inventors:

Timothy Harris - Toms River NJ, US

Assignee:

Helicos BioSciences Corporation - Cambridge MA

International Classification:

G01N 21/00

US Classification:

356436000

Abstract:

The present invention relates to apparatus, systems, and methods for analyzing biological samples. In particular, the invention provides systems and methods for analyzing samples in a light microscope. The invention allows microscopic position sensing and focusing. The invention includes the use of at least two coordinated beams of light, one of which operates to determine the position of the other. In a preferred embodiment, the system is a microscope having total internal reflection optics installed. Systems of the invention can also be constructed from a standard microscope configured with a total internal reflection objective.

Author:

Timothy S. Harris

ISBN #:

0071478965

Author:

Timothy Harris

ISBN #:

0575023651

Author:

Timothy Harris

ISBN #:

0590945572

Author:

Timothy Harris

ISBN #:

0440002184

Author:

Timothy Harris

ISBN #:

0440032342

Author:

Timothy Harris

ISBN #:

0440116708

Author:

Timothy Harris

ISBN #:

0718106962

Address:

9 Division Ave, Massapequa, NY 11758

Phone:

516 308-3381

VIN:

5NMSG13D69H310319

Make:

HYUNDAI

Model:

SANTA FE

Year:

2009