Timothy A Block

US Patent:

6465487, Oct 15, 2002

Filed:

Dec 10, 1998

Appl. No.:

09/209033

Inventors:

Timothy M. Block - Doylestown PA
Raymond A. Dwek - North Hinskey, GB
Baruch S. Blumberg - Philadelphia PA
Anand Mehta - Landenberg PA
Frances Platt - Long Hanborough, GB
Terry D. Butters - Garsington, GB
Nicole Zitzmann - Odendorf, DE

Assignee:

Synergy Pharmaceuticals, Inc. - Somerset NJ
Thomas Jefferson University - Philadelphia PA
The Chancellor, Masters and Scholars of the University of Oxford - Oxford

International Classification:

A61K 31445

US Classification:

514315, 514317, 514326, 514327, 514328

Abstract:

Methods for inhibiting morphogenesis of host cell membrane-budding viruses and infections caused thereby using compounds that inhibit host cell glucosidase or glucosyltransferase enzymes. Methods for treating lipid storage diseases using compounds that inhibit glucosyl transferance enzymes.

US Patent:

6689759, Feb 10, 2004

Filed:

Jan 19, 2000

Appl. No.:

09/355446

Inventors:

Gary S. Jacob - St. Louis MO
Timothy M. Block - Doylestown PA
Raymond A. Dwek - Oxford, GB

Assignee:

G. D. Searle Co. - Chicago IL

International Classification:

A61K 3100

US Classification:

514 45, 514 42, 514 43, 514 46, 514 47, 514 48, 514 49, 514 50, 514 51, 514 89, 514277

Abstract:

Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antivirals agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

US Patent:

7776550, Aug 17, 2010

Filed:

May 5, 2006

Appl. No.:

11/418598

Inventors:

Timothy M. Block - Doylestown PA, US
Mary Ann Comunale - Bangor PA, US
Anand Mehta - Lansdale PA, US

Assignee:

Philadelphia Health & Education Corporation - Philadelphia PA

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease states.

US Patent:

8097728, Jan 17, 2012

Filed:

Apr 30, 2008

Appl. No.:

12/112694

Inventors:

Baohua Gu - Malvern PA, US
Timothy M. Block - Doylestown PA, US
Robert M. Moriarty - Michigan City IN, US
Mahendra N. Deshpande - Gurnee IL, US
Rajendra C. Shah - Morton Grove IL, US

Assignee:

Philadelphia Health & Education Corporation - Philadelphia PA
The Board Of Trustees Of The University of Illinois - Urbana IL

International Classification:

C12N 9/99
A61P 31/14
C07D 211/40

US Classification:

546219, 435184

Abstract:

An anti-viral compounds effective against viruses belonging to the Flaviviridae family, wherein the anti-viral compounds are 1,5-dideoxy-1,5-imino-D-glucitol derivative compounds having the general formula (I).

US Patent:

8183000, May 22, 2012

Filed:

Aug 10, 2010

Appl. No.:

12/853486

Inventors:

Timothy M. Block - Doylestown PA, US
Mary Ann Comunale - Bangor PA, US
Anand Mehta - Lansdale PA, US

Assignee:

Philadelphia Health & Education Corporation - Philadelpha PA

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting lectin binding on proteins in biological fluids, and comparing the detected lectin binding with reference values for the binding of lectin of such proteins in healthy or disease states.

US Patent:

8193328, Jun 5, 2012

Filed:

Sep 7, 2006

Appl. No.:

12/065840

Inventors:

Xuanyong Lu - Horsham PA, US
Timothy Block - Doylestown PA, US

Assignee:

Philadelphia Health & Education Corporation - Philadelphia PA

International Classification:

C12N 15/15
C12N 15/11
C12N 15/113

US Classification:

536 235, 536 234, 536 245

Abstract:

This invention describes a relevant etiology of cancer and a novel anti-cancer therapeutic strategy, based on the discovery that a protein named serine protease inhibitor (SPIK/SPINK/PSTI) was up-regulated by hepatitis B and C virus infections consequently suppressing the cell apoptosis. Accordingly, this invention provides an inhibitor of SPIK and/or a technology of suppression of over-expression of SPIK in cells. The inhibitors include: 1) chemical compounds, which can inhibit SPIK transcripts, protein activity, and gene expression, 2) SPIK siRNA (RNAi gene silence or dsRNA of SPIK, 3) DNA anti-sense and anti-SPIK antibody. Further, this invention provides a method of using the inhibitor as an anti-cancer agent to re-instate cancer cell apoptosis (e. g. , serine protease dependent cell apoptosis).

US Patent:

8568984, Oct 29, 2013

Filed:

Feb 18, 2011

Appl. No.:

13/030888

Inventors:

Ying-Hsiu Su - Audubon PA, US
Benjamin Song - Audubon PA, US
Janet Song - Audubon PA, US
Timothy M. Block - Doylestown PA, US

Assignee:

Philadelphia Health & Education Corporation - Philadelphia PA

International Classification:

C07H 21/04
C12Q 1/68

US Classification:

435 612, 435 611, 435 691, 536 231, 536 243

Abstract:

Provided are methods of diagnosing and/or determining treatment of non-urinary tract cancers by detecting biomarkers, and aberrant methylation in said biomarkers, in human urine samples.

US Patent:

8609668, Dec 17, 2013

Filed:

May 4, 2007

Appl. No.:

12/299532

Inventors:

Andrea Cuconati - Oreland PA, US
Timothy M. Block - Doylestown PA, US
Xiaodong Xu - Doylestown PA, US

Assignee:

Philadelphia Health & Education Corporation - Philadelphia PA
Institute For Hepatitis and Virus Research - Doylestown PA

International Classification:

A61K 31/519
A61P 31/20
C07D 487/04

US Classification:

5142593, 544254

Abstract:

A pharmaceutical composition comprising an effective amount of a compound of formulas (I-III) and a pharmaceutically acceptable carrier. Methods for treating a hepatitis virus in a patient comprising administering an effective amount of the compound of formulas (I-III) are also presented.

Author:

Timothy A. Block

ISBN #:

0812235355

Author:

Timothy A. Block

ISBN #:

0812237854

Author:

Timothy A. Block

ISBN #:

0812240030