Gary S. Jacob - Creve Coeur MO, US Timothy M. Block - Jenkintown PA, US Raymond A. Dwek - North Hinksey, GB
Assignee:
United Therapeutics Corporation - Silver Spring MD
International Classification:
A61K 31/445 A61K 31/505 A61K 31/675
US Classification:
514315, 514274, 514 66
Abstract:
Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.
Long Chain N-Alkyl Compounds And Oxa-Derivatives Thereof
Nicole Zitzmann - Oxford, GB Terry D. Butters - Oxfordshire, GB Frances M. Platt - Oxfordshire, GB Gary S. Jacob - Creve Coeur MO, US Donald H. Picker - Warren NJ, US Sandra Carrouee - Lyons, FR George W. J. Fleet - Oxfordshire, GB Raymond A. Dwek - Oxfordshire, GB David Durantel - Arles, FR Anand Mehta - Langdale PA, US Timothy M. Block - Doylestown PA, US
Assignee:
Thomas Jefferson University - Philadelphia PA The Chancellor, Masters and Scholars of the University of Oxford - Oxford United Therapeutics Corporation - Silver Spring MD
International Classification:
C07C 211/00 C07C 303/00 C07C 307/00 C07C 309/00
US Classification:
564 1, 564 23
Abstract:
Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C-Calkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
Use Of N-Substituted-1,5-Dideoxy-1,5-Imino-D-Glucitol Compounds In Combination Therapy For Treating Hepatitis Virus Infections
Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.
Methods Of Treating Hepatitis Virus Infections With N-Substituted-1,5-Dideoxy-1,5-Imino-D- Glucuitol Compounds In Combination Therapy
Gary Jacob - Creve Coeur MO, US Timothy Block - Jenkintown PA, US Raymond Dwek - Oxford, GB
International Classification:
A61K 31/445
US Classification:
514317000, 514328000
Abstract:
Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.
Long Chain N-Alkyl Compounds And Oxa-Derivatives Thereof
Nicole Zitzmann - Oxford, GB Terry D. Butters - Oxfordshire, GB Frances M. Platt - Oxfordshire, GB Gary S. Jacob - Creve Coeur MO, US Donald H. Picker - Warren NJ, US Sandra Carrouee - Lyon, FR George W.J. Fleet - Oxfordshire, GB Raymond A. Dwek - Oxfordshire, GB David Durantel - Arles, FR Anand Mehta - Langdale PA, US Timothy M. Block - Doylestown PA, US
Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C-Calkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
Long Chain N-Alkyl Compounds And Oxa-Derivatives Thereof
Nicole Zitzmann - Oxford, GB Terry D. Butters - Oxfordshire, GB Frances M. Platt - Oxfordshire, GB Gary S. Jacob - Creve Coeur MO, US Donald H. Picker - Warren NJ, US Sandra Carrouee - Lyon, FR George W. J. Fleet - Oxfordshire, GB Raymond A. Dwek - Oxfordshire, GB David Durantel - Arles, FR Anand Mehta - Langdale PA, US Timothy M. Block - Doylestown PA, US
International Classification:
A61K 31/45 C12N 5/071 A61P 31/12
US Classification:
514315, 435325, 435366
Abstract:
Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C-Calkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
Ives Elementary School Detroit MI 1971-1972, Guyton Elementary School Detroit MI 1972-1977, Remus Robinson Middle School Detroit MI 1977-1978, Whitney Young Junior High School Detroit MI 1978-1979, Hartford Junior High School Canton OH 1979-1980, Crenshaw Middle School Canton OH 1980-1981