Timothy M Block

US Patent:

6355248, Mar 12, 2002

Filed:

Jun 17, 1999

Appl. No.:

09/334819

Inventors:

Frank Michaels - Havertown PA
Timothy Block - Doylestown PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61K 3929

US Classification:

4241891, 4241931, 4242271, 514 49

Abstract:

Methods and compositions for modulating an immune response in a mammal infected with a bacterium, a virus, or a parasite are provided. The methods and compositions are useful in mammals experiencing an acute infection and in mammals experiencing a chronic infection. The methods and compositions may be used in conjunction with a known treatment for infection of a mammal by an infectious agent. Methods and compositions for transmucosal delivery of a molecule comprising an epitope located in close proximity to the immune response are provided.

US Patent:

6465487, Oct 15, 2002

Filed:

Dec 10, 1998

Appl. No.:

09/209033

Inventors:

Timothy M. Block - Doylestown PA
Raymond A. Dwek - North Hinskey, GB
Baruch S. Blumberg - Philadelphia PA
Anand Mehta - Landenberg PA
Frances Platt - Long Hanborough, GB
Terry D. Butters - Garsington, GB
Nicole Zitzmann - Odendorf, DE

Assignee:

Synergy Pharmaceuticals, Inc. - Somerset NJ
Thomas Jefferson University - Philadelphia PA
The Chancellor, Masters and Scholars of the University of Oxford - Oxford

International Classification:

A61K 31445

US Classification:

514315, 514317, 514326, 514327, 514328

Abstract:

Methods for inhibiting morphogenesis of host cell membrane-budding viruses and infections caused thereby using compounds that inhibit host cell glucosidase or glucosyltransferase enzymes. Methods for treating lipid storage diseases using compounds that inhibit glucosyl transferance enzymes.

US Patent:

6689759, Feb 10, 2004

Filed:

Jan 19, 2000

Appl. No.:

09/355446

Inventors:

Gary S. Jacob - St. Louis MO
Timothy M. Block - Doylestown PA
Raymond A. Dwek - Oxford, GB

Assignee:

G. D. Searle Co. - Chicago IL

International Classification:

A61K 3100

US Classification:

514 45, 514 42, 514 43, 514 46, 514 47, 514 48, 514 49, 514 50, 514 51, 514 89, 514277

Abstract:

Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antivirals agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

US Patent:

6809083, Oct 26, 2004

Filed:

Feb 12, 1999

Appl. No.:

09/249220

Inventors:

Richard A. Mueller - Glencoe IL 60022
Martin L. Bryant - Los Altos CA 94024
Richard A. Partis - Evanston IL 63141
Gary S. Jacob - Creve Coeur MO 63141
Timothy M. Block - Jenkintown PA 19046
Raymond A. Dwek - Oxford OX1 3QU, GB

International Classification:

A01N 4304

US Classification:

514 45, 514 1, 514 42, 514 43, 514 89, 514277, 514315, 435 5

Abstract:

Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.

US Patent:

7612093, Nov 3, 2009

Filed:

Dec 15, 2005

Appl. No.:

11/300464

Inventors:

Gary S. Jacob - Creve Coeur MO, US
Timothy M. Block - Jenkintown PA, US
Raymond A. Dwek - North Hinksey, GB

Assignee:

United Therapeutics Corporation - Silver Spring MD

International Classification:

A61K 31/445
A61K 31/505
A61K 31/675

US Classification:

514315, 514274, 514 66

Abstract:

Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

US Patent:

7776550, Aug 17, 2010

Filed:

May 5, 2006

Appl. No.:

11/418598

Inventors:

Timothy M. Block - Doylestown PA, US
Mary Ann Comunale - Bangor PA, US
Anand Mehta - Lansdale PA, US

Assignee:

Philadelphia Health & Education Corporation - Philadelphia PA

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease states.

US Patent:

7816560, Oct 19, 2010

Filed:

Aug 10, 2000

Appl. No.:

10/031145

Inventors:

Nicole Zitzmann - Oxford, GB
Terry D. Butters - Oxfordshire, GB
Frances M. Platt - Oxfordshire, GB
Gary S. Jacob - Creve Coeur MO, US
Donald H. Picker - Warren NJ, US
Sandra Carrouee - Lyons, FR
George W. J. Fleet - Oxfordshire, GB
Raymond A. Dwek - Oxfordshire, GB
David Durantel - Arles, FR
Anand Mehta - Langdale PA, US
Timothy M. Block - Doylestown PA, US

Assignee:

Thomas Jefferson University - Philadelphia PA
The Chancellor, Masters and Scholars of the University of Oxford - Oxford
United Therapeutics Corporation - Silver Spring MD

International Classification:

C07C 211/00
C07C 303/00
C07C 307/00
C07C 309/00

US Classification:

564 1, 564 23

Abstract:

Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C-Calkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.

US Patent:

8097728, Jan 17, 2012

Filed:

Apr 30, 2008

Appl. No.:

12/112694

Inventors:

Baohua Gu - Malvern PA, US
Timothy M. Block - Doylestown PA, US
Robert M. Moriarty - Michigan City IN, US
Mahendra N. Deshpande - Gurnee IL, US
Rajendra C. Shah - Morton Grove IL, US

Assignee:

Philadelphia Health & Education Corporation - Philadelphia PA
The Board Of Trustees Of The University of Illinois - Urbana IL

International Classification:

C12N 9/99
A61P 31/14
C07D 211/40

US Classification:

546219, 435184

Abstract:

An anti-viral compounds effective against viruses belonging to the Flaviviridae family, wherein the anti-viral compounds are 1,5-dideoxy-1,5-imino-D-glucitol derivative compounds having the general formula (I).

Author:

Timothy A. Block

ISBN #:

0812235355

Author:

Timothy A. Block

ISBN #:

0812237854

Author:

Timothy A. Block

ISBN #:

0812240030