Timothy J Block

US Patent:

8097728, Jan 17, 2012

Filed:

Apr 30, 2008

Appl. No.:

12/112694

Inventors:

Baohua Gu - Malvern PA, US
Timothy M. Block - Doylestown PA, US
Robert M. Moriarty - Michigan City IN, US
Mahendra N. Deshpande - Gurnee IL, US
Rajendra C. Shah - Morton Grove IL, US

Assignee:

Philadelphia Health & Education Corporation - Philadelphia PA
The Board Of Trustees Of The University of Illinois - Urbana IL

International Classification:

C12N 9/99
A61P 31/14
C07D 211/40

US Classification:

546219, 435184

Abstract:

An anti-viral compounds effective against viruses belonging to the Flaviviridae family, wherein the anti-viral compounds are 1,5-dideoxy-1,5-imino-D-glucitol derivative compounds having the general formula (I).

US Patent:

8568984, Oct 29, 2013

Filed:

Feb 18, 2011

Appl. No.:

13/030888

Inventors:

Ying-Hsiu Su - Audubon PA, US
Benjamin Song - Audubon PA, US
Janet Song - Audubon PA, US
Timothy M. Block - Doylestown PA, US

Assignee:

Philadelphia Health & Education Corporation - Philadelphia PA

International Classification:

C07H 21/04
C12Q 1/68

US Classification:

435 612, 435 611, 435 691, 536 231, 536 243

Abstract:

Provided are methods of diagnosing and/or determining treatment of non-urinary tract cancers by detecting biomarkers, and aberrant methylation in said biomarkers, in human urine samples.

US Patent:

20100285469, Nov 11, 2010

Filed:

Oct 10, 2008

Appl. No.:

12/680654

Inventors:

Ying-Hsiu Su - Audubon PA, US
Zhili Wang - Bryn Mawr PA, US
Timothy M. Block - Doylestown PA, US
Janet Song - Audubon PA, US

Assignee:

Philadelphia Health & Education d/b/a Drexel University College of Medicine - Philadelphia PA
The Children's Hospital Of Philadelphia - Philadelphia PA

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

A method for tumor screening using urine of a mammal, the method includes obtaining a total urine nucleic acid (e.g., DNA) from a urine sample of a mammal, extracting a high molecular weight urine nucleic acid (above 1000 bp) by contacting the total urine nucleic acid with an adsorbent in the presence of a buffer which promotes binding of the high molecular weight urine nucleic acid to the adsorbent, replacing the buffer which promotes binding of the high molecular weight urine nucleic acid with a buffer which promotes binding of the low molecular weight urine nucleic acid to the adsorbent, extracting the low molecular weight urine nucleic acid by contacting with the adsorbent, eluting the low molecular weight urine nucleic acid, and assaying the low molecular weight urine nucleic acid for a presence or absence of a gene sequence specific to a certain type of tumor.

US Patent:

20110053141, Mar 3, 2011

Filed:

Aug 24, 2010

Appl. No.:

12/862545

Inventors:

Xiangdong Ren - Malvern PA, US
Timothy Block - Doylestown PA, US
Hui Nie - Doyletown PA, US

Assignee:

INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH - Doylestown PA

International Classification:

C12Q 1/70

US Classification:

435 5

Abstract:

This invention provides compositions and methods for ultrasensitive detection and quantification of mutant hepatitis B viruses (HBV). The compositions and methods of the invention can be used to detect HBV mutations for diagnostic and prognostic purposes. This invention also provides new application of a TaqMan hydrolysis probe in asymmetric real time PCR and melting curve analysis.

US Patent:

20170305856, Oct 26, 2017

Filed:

Apr 20, 2017

Appl. No.:

15/492652

Inventors:

- Doylestown PA, US
Jinhong Chang - Chalfont PA, US
Timothy Michael Block - Doylestown PA, US

International Classification:

C07D 211/40
C07C 9/15
A61K 31/13
A61K 31/45
C07D 419/12
C07D 211/36

Abstract:

Described herein are alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include viral hemorrhagic fevers and other enveloped viruses, and any other diseases involving glucosidase activity.

US Patent:

20150335630, Nov 26, 2015

Filed:

Jul 30, 2015

Appl. No.:

14/813931

Inventors:

- Doylestown PA, US
- Philadelphia PA, US
Hong Ye - Lansdale PA, US
Jinhong Chang - Chalfont PA, US
Timothy M. Block - Doylestown PA, US

International Classification:

A61K 31/45
A61K 31/4015

Abstract:

Pharmaceutical compositions of the invention comprise alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include Viral hemorrhagic fevers, and any other diseases involving glucosidase activity.

US Patent:

20150265672, Sep 24, 2015

Filed:

May 31, 2013

Appl. No.:

14/435675

Inventors:

Jinhong CHANG - Chalfont PA, US
Timothy M. BLOCK - Doylestown PA, US
William A. KINNEY - Newtown PA, US
Harold R. Almond - Maple Glen PA, US

Assignee:

DREXEL UNIVERSITY - Philadelphia PA

International Classification:

A61K 38/12
C07K 5/12
A61K 45/06

Abstract:

The present invention provides small molecule inhibitors of hepatitis B virus (HBV) covalently closed circular (ccc) DNA, which are useful as therapeutics in the management of chronic HBV. The compounds of the invention achieve epigenetic modification of the cccDNA, histone modification and histone deacetylase activity inhibition, thus modulating HBV cccDNA. The present invention further provides methods for modulating HBV cccDNA, for treating or preventing HBV in a subject, and for modulating cccDNA transcription of hepatitis B in a subject.

US Patent:

20150119366, Apr 30, 2015

Filed:

Mar 27, 2013

Appl. No.:

14/388175

Inventors:

- Doylestown PA, US
- Philadelphia PA, US
Hong Ye - Lansdale PA, US
Jinhong Chang - Chalfont PA, US
Timothy M. Block - Doylestown PA, US

International Classification:

C07D 211/46
C07F 9/59
C07D 413/06

US Classification:

514 89, 546219, 514328, 546209, 514326, 546198, 514321, 546 24, 546220

Abstract:

Pharmaceutical compositions of the invention comprise alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include Viral hemorrhagic fevers, and any other diseases involving glucosidase activity.

Author:

Timothy A. Block

ISBN #:

0812235355

Author:

Timothy A. Block

ISBN #:

0812237854

Author:

Timothy A. Block

ISBN #:

0812240030